Tag: M.W:200-300

Guo, Yu; Wang, Ruo-Ya; Kang, Jia-Xin; Ma, Yan-Na; Xu, Cong-Qiao; Li, Jun; Chen, Xuenian published an article about the compound: Methyl 6-bromonicotinate( cas:26218-78-0,SMILESS:C1=NC(=CC=C1C(=O)OC)Br ).Electric Literature of C7H6BrNO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:26218-78-0) through the article.

Authors report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quant. conversion and wide applicability for esters tolerating different functional groups. The exptl. and theor. studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction.

This compound(Methyl 6-bromonicotinate)Electric Literature of C7H6BrNO2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Influence of isoproterenol on net potassium uptake in whole pigeon erythrocytes in vitro, published in 1981-11-30, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, Synthetic Route of C13H20N4O2.

isoproterenol (I) [7683-59-2] increases net uptake of K in whole pigeon erythrocytes in vitro; the effect of 10-5 M isoproterenol is blocked by 10-4 M propranolol. Pentifylline, a potent inhibitor of cAMP phosphodiesterase, significantly amplifies the effect of isoproterenol, indicating that the isoproterenol effect is mediated by cyclic AMP  [60-92-4]. Cyclic AMP alone has no direct influence on net K uptake, whereas dibutyryl cAMP has a very weak effect. Isoproterenol effects may be mediated by cell membrane protein phosphorylation.

This compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Synthetic Route of C13H20N4O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Category: tetrahydrofurans. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about Modulation of Topological Structures and Adsorption Properties of Copper-Tricarboxylate Frameworks Enabled by the Effect of the Functional Group and Its Position. Author is Lin, Shengjie; Zhou, Ping; Xu, Tingting; Fan, Lihui; Wang, Xinxin; Yue, Lianglan; Jiang, Zhenzhen; Zhang, Yuanbin; Zhang, Zhengyi; He, Yabing.

To push forward the structural development and fully explore the potential utility, it is highly desired but challenging to regulate in a controllable manner the structures and properties of MOFs. The authors reported the structural and functional modulation of Cu(II)-tricarboxylate frameworks by employing a strategy of engineering the functionalities and their positions. Two pairs of unsym. biaryl tricarboxylate ligands modified with a Me group and a pyridinic-N atom at distinct positions were logically designed and synthesized, and their corresponding Cu(II)-based MOFs were solvothermally constructed. Diffraction analyses revealed that the variation of functionalities and their positions furnished three different types of topol. structures, which the authors ascribed to the steric effect exerted by the Me group and the chelating effect involving the pyridinic-N atom. Also, gas adsorption studies showed that three of them are potential candidates as solid separation media for acetylene (C2H2) purification, with the separation potential tailorable by altering functionalities and their locations. At 106.7 kPa and 298 K, the C2H2 uptake capacity varies from 64.1 to 132.4 cm3 (STP) g-1, while the adsorption selectivities of C2H2 over its coexisting components of CO2 and CH4 fall at 3.28-4.60 and 14.1-21.9, resp.

This compound(Methyl 6-bromonicotinate)Category: tetrahydrofurans was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 8-Bromoguanine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Prediction of Interaction Energies of Substituted Hydrogen-Bonded Watson-Crick Cytosine:Guanine8X Base Pairs. Author is Xue, Chunxia; Popelier, Paul L. A..

We investigated the variation in the interaction energy between the Watson-Crick hydrogen-bonded DNA base pairs guanine and cytosine (G8X:C), where guanine is substituted in the C8 position by 37 different functional groups. Base pairs were optimized at the B3LYP/6-311+G(2d,p) level. A base pair complex containing a more strongly electron-withdrawing group remarkably forms a more stable base pair with C. Multivariate linear regression provided a quant. relationship between the interaction energies and descriptors generated by the quantum chem. topol. (QCT) approach. The descriptors were sampled from the monomers only, not the supermol. base pair complexes. A model with r2 = 0.96 and a root-mean-square (rms) value of 0.6 kJ/mol was obtained for a training set of 28 base pair complexes. The model was tested by an external test set of 9 complexes, yielding r2 = 0.99 and an rms value of 0.2 kJ/mol. The results indicated that the bonds C6=O6 and N2-H2 at the hydrogen-bonded frontier of the guanine derivatives play an important role in transmitting the substituent effects. A linear correlation between substitution energies and Hammett constants (σm) was also obtained for all 37 substituents, yielding r2 = 0.82 and an rms value of 1.2 kJ/mol. The model based on QCT descriptors can therefore be used for the prediction of the interaction energy of the base pair G8X:C, strictly based on data for the G8X monomers only.

This compound(8-Bromoguanine)Quality Control of 8-Bromoguanine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Alkylation of nucleic acids. I. Comparison study of the methylation of ribonucleic acids in aqueous and organic solutions》. Authors are Bollack, C.; Keith, G.; Ebel, J. P..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Electric Literature of C5H4BrN5O. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

Methylation of ribosomal and soluble RNA (from bakers’ yeast) by Me2SO4 in dimethylformamide (I) solution gives rise to the same derivatives as the methylation in aqueous solution, namely, 7-methylguanine, 1-methyladenine, and 1-methylcytosine. Uracil is not methylated. The percentages of methylated bases formed are lower in I medium than in water. Differences in the order of reactivity of the bases are observed according to the reaction carried out in I or in water. Methylation in aqueous solution does not affect the integrity of the RNA mols., even for high methylation percentages; but, methylation in I causes a degradation of the polynucleotide chains, especially for ribosomal RNA. Methylation causes some alteration of the secondary structure of soluble RNA and this alteration increases as the methylation percentage increases.

This compound(8-Bromoguanine)Electric Literature of C5H4BrN5O was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3066-84-0, is researched, SMILESS is NC(N1)=NC(NC(Br)=N2)=C2C1=O, Molecular C5H4BrN5OJournal, Article, European Journal of Pharmaceutics and Biopharmaceutics called Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors, Author is Schluetke, Laura; Immer, Markus; Preu, Lutz; Totzke, Frank; Schaechtele, Christoph; Kubbutat, Michael H. G.; Kunick, Conrad, the main research direction is purine derivative anaplastic lymphoma kinase inhibitor; Anaplastic lymphoma kinase, ALK; EML4-ALK fusion; Gatekeeper mutation; Protein kinase inhibitor; Purine; Scaffold hopping; Solubility; Thieno[3,2-d]pyrimidine; c-Met.Safety of 8-Bromoguanine.

Rearrangements of anaplastic lymphoma kinase (ALK) are associated with several cancer diseases. Due to resistance development against existing ALK-inhibitors, new, structurally unrelated inhibitors are required. By a scaffold hopping strategy, 6,8-disubstituted purines were designed as analogs of similar ALK-inhibiting thieno[3,2-d]pyrimidines. While the new title compounds indeed inhibited ALK and several ALK mutants in submicromolar concentrations, they retained poor water solubility

This compound(8-Bromoguanine)Safety of 8-Bromoguanine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about Proximity effects in pyridines. Proton chemical shifts in substituted methyl pyridinecarboxylates.Related Products of 26218-78-0.

The chem. shifts in 6 series of substituted Me pyridinecarboxylates were measured and interpreted in terms of proximity effects. The shifts for ring H ortho and para to the substituent were explained by additive ester, nitrogen, and substituent effects. The results for meta H indicated substituent-nitrogen interactions, especially when both substituent and H were adjacent N. Similar results were obtained for the ester H.

This compound(Methyl 6-bromonicotinate)Related Products of 26218-78-0 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of Methyl 6-bromonicotinate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about K2S2O8-induced site-selective phenoxazination/phenothiazination of electron-rich anilines. Author is Zhang, He; Wang, Shengchun; Wang, Xiaoyu; Wang, Pengjie; Yi, Hong; Zhang, Heng; Lei, Aiwen.

By using cheap K2S2O8 as the oxidant at room temperature in the air, the phenoxazination/phenothiazination of electron-rich anilines has been developed. This method demonstrates complete para-selective amination under catalyst-free conditions, and its simplicity and efficiency lead to good performance in flow-chem. synthesis.

Different reactions of this compound(Methyl 6-bromonicotinate)Quality Control of Methyl 6-bromonicotinate require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 26218-78-0, is researched, Molecular C7H6BrNO2, about Functionalization of bis-diazaphospholene P-P bonds with diverse electrophiles, the main research direction is functionalization diazaphospholene dimer electrophile; phosphorus bond cleavage diazaphospholene dimer electrophile; crystal mol structure diazaphospholene dimer functionalized product.Electric Literature of C7H6BrNO2.

Readily prepared bis-diazaphospholenes are shown to react with several classes of electrophiles, resulting in cleavage of the phosphorus-phosphorus bond and formation of functionalized diazaphospholenes. Phosphorus – sp3 or sp2 carbon and phosphorus – sulfur bonds were formed using this protocol. Exptl. evidence with aryl and alkyl halides suggests the intermediacy of radicals in some cases, however other evidence suggests either radical or polar mechanisms may be operative for certain substrates, with a dependence on reaction conditions. In some cases, the substituted diazaphospholenes can transfer the substituent to electrophiles via previously unknown reactions. These results show diazaphospholene dimers are potent participants in radical chem. at room temperature without requiring chem. initiators.

Different reactions of this compound(Methyl 6-bromonicotinate)Electric Literature of C7H6BrNO2 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1028-33-7, is researched, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, P.H.S., Journal of Virology called Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard, Author is Poon, Betty; Jowett, Jeremy B. M.; Stewart, Sheila A.; Armstrong, Robert W.; Rishton, Gilbert M.; Chen, Irvin S. Y., the main research direction is HIV1 virus vpu gene nitrogen mustard.Application In Synthesis of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.

The product of the human immunodeficiency virus type 1 (HIV-1) vpr gene induces cell cycle arrest in the G2 phase of the cell cycle and is characterized by an accumulation of the hyperphosphorylated form of cdc2 kinase. This phenotype is similar to the effect of DNA-damaging agents, which can also cause cells to arrest at G2. We previously reported that Vpr mimicked some of the effects of a DNA alkylating agent known as nitrogen mustard (HN2). Here we extend these earlier observations by further comparing the activation state of cdc2 kinase, the kinetics of G2 arrest, and the ability to reverse the arrest with chem. compounds known as methylxanthines. Infection of cells synchronized in the G1 phase of the cell cycle with a pseudotyped HIV-1 resulted in arrest at G2 within 12 h postinfection, before the first mitosis. Similar to that induced by HN2, Vpr-induced arrest led to a decrease in cdc2 kinase activity. Vpr-mediated G2 arrest was alleviated by methylxanthines at concentrations similar to those needed to reverse the G2 arrest induced by HN2, and cells proceeded apparently normally through at least one complete cell cycle. These results are consistent with the hypothesis that Vpr induces G2 arrest through pathways that are similar to those utilized by DNA-damaging agents.

Different reactions of this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Application In Synthesis of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem