Tag: M.W=150-200

Xu, Wenhua; Ma, Xiaoru; Su, Yuanhai; Song, Yang; Shang, Minjing; Lu, Xuemin; Lu, Qinghua published the artcile< Synthesis of highly transparent and thermally stable copolyimide with fluorine-containing dianhydride and alicyclic dianhydride>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is transparent polyimide film material preparation alicyclic dianhydride diamine.

The development of optical films is highly desirable for applications in flexible displayers. In this work, a copolyimide (co-PI) film with high thermal stability and high transparency was prepared by the copolymerization of 2,2′-bis(trifluoromethyl)-4,4′-diaminodiphenyl ether, cyclobutanetetracarboxylic dianhydride, and 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA). The effects of aliphatic dianhydride and fluorine dianhydride monomers on the optical, thermal, and mech. properties of the co-PIs were discussed in detail based on the exptl. results and theor. simulations. We found that the preparation of polyimide (PI) based on the combination of two dianhydrides could obtain the PI film with excellent comprehensive performance due to nonconjugated structure and strong electron-withdrawing effect. Through the structure and composition optimization, a PI film of PI-6FDA-70 with Tg of 300°C, Td10% more than 500°C, the average transparency of 90% and the elongation at the breakage more than 8% was prepared Such mol. design provides a practical approach to develop high-performance colorless PI films.

Journal of Applied Polymer Science published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Liu, Sha; Lu, Hongtong; Li, Xiaoyuan; Zhou, Dongfang; Huang, Yubin published the artcile< Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy>, HPLC of Formula: 4415-87-6, the main research area is platinum polymeric nanoplatform CRISPR gene editing synergistic cancer therapy.

CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment. However, development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biol. safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges. Herein, a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system (NPCSPt/pEZH2) and synergistic treatment of prostate cancer. The pEZH2/Pt(II) could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells. The EZH2 gene disruption efficiency could be achieved up to 32.2% of PC-3 cells in vitro and 21.3% of tumor tissues in vivo, leading to effective suppression of EZH2 protein expression. Moreover, significant H3K27me3 downregulation could occur after EZH2 suppression, resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II) to nuclear DNA for enhanced apoptosis. Taken together, substantial proliferation inhibition of prostate cancer cells and further 85.4% growth repression against s.c. xenograft tumor could be achieved. This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery, but also broadens the potential of combining gene editing-chemo synergistic cancer therapy.

Nano Research published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, HPLC of Formula: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lu, Yunhua; Zhang, Jianhua; Xiao, Guoyong; Li, Lin; Hou, Mengjie; Hu, Junyi; Wang, Tonghua published the artcile< Synthesis and gas permeation properties of thermally rearranged poly(ether-benzoxazole)s with low rearrangement temperatures>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is polyetherbenzoxazole synthesis thermal rearrangement gas permeation property.

The diamine monomer, 9,9-bis[4-(4-amino-3-hydroxylphenoxy)phenyl] fluorene (bis-AHPPF) was successfully synthesized according to our modified method. A series of hydroxyl-containing poly(ether-imide)s (HPEIs) were prepared by polycondensation of the bis-AHPPF diamine with six kinds of dianhydrides, including 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), pyromellitic dianhydride (PMDA), 3,3′,4,4′-biphenyl tetracarboxylic diandhydride (BPDA), 3,3′,4,4′-oxydiphthalic anhydride (ODPA), 3,3′,4,4′-benzophenonetetracarboxylic dianhydride (BTDA) and 4,4′-(hexafluoroisopropylidine)diphthalic anhydride (6FDA) followed by thermal imidization. The corresponding thermally rearranged (TR) membranes were obtained by solid state thermal treatment at high temperature under a nitrogen atm. The chem. structure, and phys., thermal and mech. properties of the HPEI precursors were characterized. The effects of heat treatment temperature and dianhydrides on the gas transport properties of the poly(ether-benzoxazole) (PEBO) membranes were also investigated. It was found that these HPEIs showed excellent thermal and mech. properties. All the HPEI precursors underwent thermal conversion in a N2 atmosphere with low rearrangement temperatures The gas permeabilities of the PEBO membranes increased with the increase of thermal treatment temperature When HPEI-6FDA was treated at 450°C for 1 h, the H2, CO2, O2 and N2 permeabilities of the membrane reached 239.6, 196.04, 46.41 and 9.25 Barrers coupled with a O2/N2 selectivity of 5.02 and a CO2/N2 selectivity of 21.19. In six TR-PEBOs, PEBO-6FDA exhibited the lowest rearrangement temperature and largest gas permeabilities. Therefore, thermally rearranged membranes from bis-AHPPF-based HPEIs are expected to be promising materials for gas separation

RSC Advances published new progress about Complex modulus, tan δ. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hu, Kaitai; Ye, Qingqing; Fan, Yingtao; Nan, Junyi; Chen, Fangyuan; Gao, Yang; Shen, Yingzhong published the artcile< Preparation and characterization of organic soluble polyimides with low dielectric constant containing trifluoromethyl for optoelectronic application>, Related Products of 4415-87-6, the main research area is organic polyimide dielec trifluoromethyl optoelectronic.

Polyimide (PI) films have excellent comprehensive properties and bright prospects in the next generation of optoelectronic and microelectronic applications. PIs were synthesized by aromatic diamines and alicyclic dianhydrides considered to be the most effective method for preparing polyimides with high light transmittance and low dielec. constant In order to improve the overall performance of polyimide, the introduction of a large trifluoromethyl group into the main chain is also considered a powerful strategy. In this article a novel diamine containing 6 trifluoromethyl groups has been designed and synthesized by Suzuki reaction. Afterwards, PIs were synthesized with fluorinated aromatic dianhydride and alicyclic dianhydride through a two-step method. The two PIs have excellent solubility: PI-a and PI-b exhibited excellent solubility in common polar solvents. Such as DMF, DMAc, NMP and DMSO at room temperature, and PI-a was soluble in low-boiling solvents such as Et acetate, CH2Cl2 and CHCl3 at room temperature PI-b was soluble in low-boiling solvents acetone and CHCl3 at room temperature, which was rarely seen in other aromatic polyimides. Soluble in common organic solvents, especially low b.p. solvents, made these polymers easy to process and suitable for processing technol. in solution This was an important modification for PIs. They also showed good high temperature resistance: the decomposition temperature (T5%) of two PIs were 520°C and 475°C. In addition, the residual rate at 790°C was 50% and 49% resp. Two PI films had a very low dielec. constant 2.26 and 2.24, resp., which was attributed to the hyperbranched structure and strong electron-withdrawing fluorine-containing groups. PI-a and PI-b also had low water absorption of 0.66% and 0.72%, resp. The transmittance of PI-a and PI-b high transparent films at 450 nm were 74% and 82%, resp. The significant optical modification was mainly due to the weak electron-accepting alicyclic unit and the large trifluoromethyl electron withdrawing group. This work mainly provided an effective strategy for synthesizing comprehensive excellent performance PIs with high transmittance, excellent solubility, low water absorption, high heat resistance and low dielec. constant

European Polymer Journal published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Related Products of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bai, Wu; Hu, Zhizhi; Lu, Yunhua; Xiao, Guoyong; Zhao, Hongbin; Zhu, Jianmin; Liu, Zhaobin published the artcile< Solubility, thermal and photoluminescence properties of triphenyl imidazole-containing polyimides>, COA of Formula: C8H4O6, the main research area is triphenyl imidazole polyimide preparation solubility thermal photoluminescence property.

In this paper, three kinds of tri-Ph imidazole-containing diamines including 2-phenyl-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (PBAI), 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethyl phenoxy)phenyl)imidazole (MPBAI) and 2-(4-trifluoromethylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (TFPBAI) were synthesized. Then, a series of polyimide (PI) films were prepared by the solution polymerization of the three diamines and various dianhydrides, such as 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), 1,2,4,5-pyromellitic dianhydride (PMDA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), followed by thermal imidization. The effects of chem. structures on the solubilities and thermal, optical and electrochem. properties of polyimides were explored. All the polyimides exhibited higher glass transition temperatures around 300°C and excellent solubilities in common polar solvents. The polyimide films derived from CBDA or 6FDA showed better optical properties with light color and transparent characteristics. The fluorescence test showed that the photoluminescence color of CBDA-based polyimide films is in the blue range in the CIE 1931 spectrum, while the polyimide film based on PMDA and 6FDA presented black or weak yellow light. However, all these polyimides in solution exhibited similar blue luminescence. Electrochem. tests indicated that the HOMO and LUMO values of these films were around -6.5 and -3.6 eV, and the energy gap difference was about 3.0 eV. Therefore, the tri-Ph imidazole-containing polyimides exhibit comprehensive performance, which will be expected as a new kind of functional material for certain application in the optical and optoelectronics fields.

RSC Advances published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, COA of Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yusof, Fitri Adila Amat; Noda, Takumi; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Critical Electric Field and Activation Energy for Electric Conductivity for Biopolyimide Using 4,4'-Diamino-α-truxillic Acid and 1,2,3,4-Cyclobutanetetracarboxylic Dianhydride>, Formula: C8H4O6, the main research area is biopolyimide preparation elec property.

Biopolyimides poly(ATA-CBDA) made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) were synthesized and its elec. volume resistivity measured at various elec. voltages at 10-60°C. The volume resistivity for Kapton and biopolyimide films showed a sudden decrease at a critical elec. field of 2.6 x 107 and 1.0 x 107 V/m, resp. The activation energy at low elec. field for Kapton and biopolyimide was 68 and 90 kJ/mol, resp., meanwhile at high elec. field for Kapton and biopolyimide was 45 and 74 kJ/mol, resp. These results indicate that the carriers for elec. conduction for biopolyimide weakly interact with the polymer chain and the biopolyimide contains many conductive carriers than Kapton.

Chemistry Letters published new progress about Activation energy (of volume resistivity). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hirayama, Thawinda; Kumar, Amit; Takada, Kenji; Kaneko, Tatsuo published the artcile< Morphology-Controlled Self-Assembly and Synthesis of Biopolyimide Particles from 4-Amino-L-phenylalanine>, Quality Control of 4415-87-6, the main research area is morphol selfassembly biopolyimide particle aminophenylalanine.

Self-assembling polyimides (PIs) having diketopiperazine (DKP) components were synthesized by polycondensation of a 4-amino-L-phenylalanine (4APhe) dimer, an aromatic diamine newly designed in this study. The amino acid-derived PIs showed high thermal resistance, with a 10% weight loss temperature (Td10) of 432°C at the maximum, and did not show any glass transition below the thermal decomposition temperature The poly(amic acid) (PAA) precursors formed nanospheres upon reprecipitation over dimethylacetamide into water. The nanospheres were then added to solvents with different polarities and sonicated to induce deformation of the spherical forms into spiky balls, flakes, or rods. The PAA particle morphologies were retained in the PIs after the two-step imidization. Finally, the PI particles with self-assembling DKP moieties were formed, and their morphologies were fine-tuned using different mixed solvents.

ACS Omega published new progress about Imidation. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bai, Wu; Lu, Yunhua; Hu, Zhizhi; Xiao, Guoyong; Zhao, Hongbin; Zhu, Jianmin; Liu, Zhaobin published the artcile< Photoluminescence, thermal and surface properties of triarylimidazole-containing polyimide nanocomposite films>, Quality Control of 4415-87-6, the main research area is polyimide inorganic filler nanocomposite photoluminescence thermal surface property.

In this work, a triarylimidazole-containing diamine 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (MPBAI) was firstly synthesized and polymerized with 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) to prepare transparent polyimide (PI) films by means of thermal imidization. Then, inorganic nanoparticles including silica (SiO2), alumina (Al2O3) and silicon nitride (Si3N4) were sep. introduced into the PI(MPBAI-CBDA) with different mass fractions of 0.02%, 0.10%, 0.50% and 2.50% to obtain three series of PI nanocomposite films. All these films were close to colorless and transparent, although the light transmittance showed a downward trend due to the introduction of nanoparticles. Moreover, as the content of inorganic nanoparticles increased, the fluorescence intensities of these films were increased. Comparatively, the improvement effect of nano-SiO2 was the most obvious. When the content of SiO2 was 2.50%, the maximum intensity of the fluorescence absorption peak was increased by 9.6 times, and the absolute fluorescence quantum yield reached 17.2%, about 5.2 times that of the original PI film. Moreover, the maximum absorption peak produced a red shift of 85 nm due to the addition of 2.50% Si3N4, which was probably caused by the weakening of fluorescence quenching effect and high permittivity. The nanocomposites exhibited high glass transition temperatures of around 300°C and excellent thermal stabilities. The surface hydrophobicity was changed by adjusting the mass and type of nanoparticles. Thus, this work provided a simple way to improve the photoluminescence effect by introducing the nanoparticles. The functional films will be expected to be applied in some optical applications.

RSC Advances published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Lu, Hongtong; Cheng, Yilong; Zhou, Dongfang; Huang, Yubin published the artcile< Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer>, SDS of cas: 4415-87-6, the main research area is tumor antitumor gene therapy prodrug cisplatin; N3•-assisted photochemical internalization; gene delivery; photoactivatable polymeric nanoparticles; photoactivated chemotherapy; platinum-resistant ovarian cancer.

Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal escape and controllable drug release/gene unpacking is the major bottleneck for maximizing the combinational therapeutic efficacy. In this work, we developed a photoactivatable Pt(IV) prodrug-backboned polymeric nanoparticle system (CNPPtCP/si(c-fos)) for light-controlled si(c-fos) delivery and synergistic photoactivated chemotherapy (PACT) and RNA interference (RNAi) on platinum-resistant ovarian cancer (PROC). Upon blue-light irradiation (430 nm), CNPPtCP/si(c-fos) generates oxygen-independent N3• with mild oxidation energy for efficient endo/lysosomal escape through N3•-assisted photochem. internalization with less gene deactivation. Thereafter, along with Pt(IV) prodrug activation, CNPPtCP/si(c-fos) dissociates to release active Pt(II) and unpack si(c-fos) simultaneously. Both in vitro and in vivo results demonstrated that CNPPtCP/si(c-fos) displayed excellent synergistic therapeutic efficacy on PROC with low toxicity. This PACT prodrug-backboned polymeric nanoplatform may provide a promising gene/drug codelivery tactic for treatment of various hard-to-tackle cancers.

Nano Letters published new progress about Animal gene, c-fos Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, SDS of cas: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nam, Ki-Ho; Jin, Jeong-un; Lee, Dong Hoon; Han, Haksoo; Goh, Munju; Yu, Jaesang; Ku, Bon-Cheol; You, Nam-Ho published the artcile< Towards solution-processable, thermally robust, transparent polyimide-chain-end tethered organosilicate nanohybrids>, Formula: C8H4O6, the main research area is polyimide nanohybrid optical elec thermal property.

The main challenge to developing future display substrates is to synthesize flexible substrate materials that also have excellent optical and thermal properties, and low thermal expansion number In this study, a novel trifluoromethylated asym. aromatic diamine, 4-[[4-(4-amino-2-trifluoromethylphenoxy)phenyl]sulfonyl-3-(trifluoromethyl)]benzenamine (AFPSFB), was synthesized through nucleophilic substitution. Conventional two-step polycondensation of AFPSFB with com. available tetracarboxylic dianhydrides enabled the fabrication of fully or semi-aromatic polyimides (PIs). The resulting PIs were highly soluble in polar aprotic solvents with good optical and thermal properties. Next, polyhedral oligomeric silsesquioxane containing an amine group (NH2-POSS) was reacted with the resulting soluble PI. All the PI-POSS nanohybrids displayed excellent optical properties, including high transparency (>91% at 400 nm), low refractive index (<1.5589), and very small birefringence (<0.0025 at 637 nm). End-capping of the POSS and chem. bonding between the POSS and PIs significantly enhanced the thermal and elec. properties. The results provide useful information for designing mol. architectures for manufacturing high-performance flexible substrates in future display devices. Composites, Part B: Engineering published new progress about Additive polymerization. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem