Tag: M.W:100-200

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 233 (0553) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.16 g, 1.16 mmol) and triethylamine (0.12 g, 1.16 mmol) were added to chloroform (amylene addition product) (5 mL). 5-(3-Phenyl-(E)-2-propenyloxymethyl)isoxazole-3-carboxylic acid (0.25 g, 0.96 mmol), 1-hydroxybenzotriazole (0.01 g, 0.10 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.22 g, 1.16 mmol) were added to the mixture at room temperature, and the mixture was stirred at room temperature overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.25 g of N-(tetrahydrofuran-3-ylmethyl)-5-(3-phenyl-(E)-2-propenylox ymethyl)isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (242)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.64-1.72(1H, m), 2.05-2.13(1H, m), 2.53-2.63(1H, m), 3.45-3.48(2H, m), 3.57-3.61(1H, m), 3.74-3.80(1H, m), 3.84-3.95(2H, m), 4.25(2H, d), 4.68(2H, s), 6.24-6.31(1H, m), 6.65(1H, d), 6.74(1H, s), 6.95(1H, br s), 7.25-7.28(1H, m), 7.32-7.35(2H, m), 7.39-7.41(2H, m)

184950-35-4, As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

89364-31-8, Tetrahydrofuran-3-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tetrahydro-3-furancarboxylic acid (20.00 g, 172 mmol) in MeOH (350 mL) was added sulfuric acid (27.54 mL, 517 mmol). The reaction was heated to reflux for 18 h. The reaction was then cooled to rt and concentrated. The residue was partitioned between water (500 mL) and DCM (200 mL). The phases were separated and the aqueous fraction was extracted with DCM (200 mL). The combined organic fractions were washed with saturated aqueous NaHCO3 (200 mL) and brine (200 mL), dried over Na2SO4, filtered, and concentrated to afford methyl tetrahydro-3-furancarboxylate (15.0 g, 67% yield) as a pale yellow oil. 1H NMR (400 MHz, DMSO-d) delta ppm 3.85 (t, J=8.4 Hz, 1H), 3.77-3.66 (m, 3H), 3.62 (s, 3H), 3.07-3.22 (m, 1H), 1.97-2.12 (m, 2H)., 89364-31-8

The synthetic route of 89364-31-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantbio, Inc.; Tao, Chunlin; Nallan, Laxman; Ho, David G.; Wang, Qinwei; Weingarten, Paul; Juncker-Jensen, Anna B.; (121 pag.)US2018/201610; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5061-21-2, alpha-Bromo-gamma-butyrolactone (1) (925 mul, 10 mmol, 1 equiv) was dissolved in acetone (17 ml) and a solution of NaN3 (3.25 g in 7 ml H2O, 50 mmol, 5 equiv) was added. The resulting solution was stirred overnight. Acetone was removed by evaporation under reduced pressure. The resulting aqueous mixture was extracted with CH2Cl2 (2 ¡Á 50 mL) and the organic layers were combined, dried over Na2SO4, filtered, and evaporated under reduced pressure. The resulting oil was found to be pure by NMR analysis (and was used without further purification). 1H NMR (300 MHz, CDCl3): delta 4.42 (dt, 1H, J = 3.6 Hz and 8.9 Hz, H-3), 4.23-4.31 (m, 2H, H-3 and H-1), 2.50-2.61 (m, 1H, H-2), 2.10-2.24 (m, 1H, H-2); 13C NMR (75 MHz, CDCl3): delta 173.6, 66.0, 56.8, 29.1

5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Brackman, Gilles; Risseeuw, Martijn; Celen, Shari; Cos, Paul; Maes, Louis; Nelis, Hans J.; Van Calenbergh, Serge; Coenye, Tom; Bioorganic and Medicinal Chemistry; vol. 20; 15; (2012); p. 4737 – 4743;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Production Example 265 (0586) 5-(2,3-Difluorobenzyloxymethyl)isoxazole-3-carboxylic acid (0.54 g, 2.0 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.41 g, 3.0 mmol), triethylamine (0.30 g, 3.0 mmol) and 1-hydroxybenzotriazole (0.03 g, 0.2 mmol) were added to chloroform (amylene addition product) (5 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.46 g, 2.4 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated saline water and dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.25 g of N-(tetrahydrofuran-3-ylmethyl)-5-(2,3-difluorobenzyloxymeth yl)isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (274)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta (ppm)) : 1.63-1.73 (1H, m), 2.05-2.15 (1H, m), 2.53-2.64 (1H, m), 3.47(2H, t), 3.59 (1H, dd), 3.73-3.81 (1H, m), 3.83-3.96(2H, m), 4.69(2H, s), 4.70(2H, s), 6.75(1H, s), 6.94 (1H, br s), 7.07-7.22(3H, m)

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

144870-96-2, 4-Aminotetrahydrofuran-3-ol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-aminotetrahydrofuran-3-ol (74.5 mg, 0.722 mmol) and ethyl 4-(chlorosulfonyl)-3-fluoro-l-methyl-lH-pyrrole-2-carboxylate (150 mg, 0.556 mmol) in dry acetonitrile (4 mL), dry DIPEA (0.3 mL, 1.7223 mmol) was added at rt. After lh mixture was evaporated under reduced pressure to afford a yellow solid (325 mg). Crude was purified by flash chromatography (Petroleum ether/ AcOEt) to afford D44 as a light yellow solid (178 mg, y= 95%). Method 1 : Rt=l.28 min, m/z=337 (M+H)+. The compound is the trans racemic mixture at the tetrahydrofuranyl ring., 144870-96-2

144870-96-2 4-Aminotetrahydrofuran-3-ol 10486809, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; OSPEDALE SAN RAFFAELE S.R.L.; IRBM S.P.A.; PROMIDIS S.R.L.; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE – INGM; DE FRANCESCO, Raffaele; DONNICI, Lorena; GUIDOTTI, Luca; IANNACONE, Matteo; DI FABIO, Romano; SUMMA, Vincenzo; PRANDI, Adolfo; RANDAZZO, Pietro; GORNATI, Davide; GRILLO, Alessandro; FERRANTE, Luca; BENCHEVA, Leda Ivanova; DE MATTEO, Marilenia; FERRARA, Marco; (238 pag.)WO2020/30781; (2020); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem