Tag: M.W=100-150

Graves, Brian M. published the artcileComprehensive characterization of mainstream marijuana and tobacco smoke, Category: tetrahydrofurans, the publication is Scientific Reports (2020), 10(1), 7160, database is CAplus and MEDLINE.

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quant. similar in volatility, shape, d. and number concentration, albeit with differences in size, total mass and chem. composition Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4 times more total mass. New measurements of semivolatile fractions determined that >97% of the mass and volume of the particles from either smoke source are comprised of semivolatile compounds For tobacco smoke and marijuana smoke, resp., 4350 and 2575 different compounds are detected, of which 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause neg. health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their phys. and chem. properties.

Scientific Reports published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kim, Jung-Hun published the artcileComparative study on carbon dioxide-cofed catalytic pyrolysis of grass and woody biomass, SDS of cas: 19444-84-9, the publication is Bioresource Technology (2021), 124633, database is CAplus and MEDLINE.

This study investigated the mechanistic functions of CO₂ on the pyrolysis of two different biomasses to elucidate the effect of CO₂ on syngas formations during pyrolysis. To this end, CO₂-assisted pyrolysis of cellulosic biomass (barnyard grass, Echinochloa) and lignin-rich woody biomass (retinispora, Chamaecyparis obtusa) were compared. The confirmed mechanistic effectiveness of CO₂ on pyrolysis of biomass was gas phase reactions between CO₂ and volatile matters from biomass pyrolysis. Lignin-rich biomass had more CO₂ susceptibility, resulting in more enhanced CO formation via the gas phase reactions. To expedite the slow reaction rate of the gas phase reactions during biomass pyrolysis, earth-abundant catalysts (Co/SiO₂ and Ni/SiO₂) were employed for pyrolysis of two biomass substrates. With Co and Ni catalysts, the syngas formations were 2 and 3 times higher comparing to the pyrolysis of without catalyst. The cumulative formations of syngas from lignin-rich biomass was nearly doubled than that from cellulosic biomass.

Bioresource Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kiddane, Anley Teferra published the artcileAnticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa Using Crude Extract of Ganoderma applanatum, Synthetic Route of 19444-84-9, the publication is Current Issues in Molecular Biology (2022), 44(3), 1012-1026, database is CAplus and MEDLINE.

Cancer is currently one of the foremost health challenges and a leading cause of death worldwide. Cervical cancer is caused by cofactors, including oral contraceptive use, smoking, multiparity, and HIV infection. One of the major and considerable etiologies is the persistent infection of the oncogenic human papilloma virus. G. applanatum is a valuable medicinal mushroom that has been widely used as a folk medicine for the treatment and prevention of various diseases. In this study, we obtained crude extract from G. applanatum mushroom with a subcritical water extraction method; cell viability assay was carried out and the crude extract showed an antiproliferative effect in HeLa cells with IC50 of 1.55 ± 0.01 mg/mL; however, it did not show any sign of toxicity in HaCaT. Protein expression was detected by Western blot, stability of IκBα and downregulation of NFκB, IKKα, IKKβ, p-NFκB-65(Ser 536) and p-IKKα/β(Ser 176/180), suggesting loss of survival in a dose-dependent manner. RT-qPCR revealed RNA/mRNA expression; fold changes of gene expression in Apaf-1, caspase-3, cytochrome-c, caspase-9, Bax and Bak were increased, which implies apoptosis, and NFκB was decreased in a dose-dependent manner. DNA fragmentation was seen in the treatment groups as compared to the control group using gel electrophoresis. Identification and quantification of compounds were carried out by GC-MS and HPLC, resp.; 2(5H)furanone with IC50 of 1.99 ± 0.01 μg/mL could be the responsible anticancer compound In conclusion, these findings suggest the potential use of the crude extract of G. applanatum as a natural source with anticancer activity against cervical cancer.

Current Issues in Molecular Biology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Varghese, Sincy published the artcileAntidiabetic and antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar rats, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Biocatalysis and Agricultural Biotechnology (2021), 102095, database is CAplus.

The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic and antilipidemic tests indexes of exptl.-induced hyperglycemic rats. High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of C. paniculatum flower (2000 mg/kg body weight) and antidiabetic effect of CPF (200 mg/kg body weight)were studied in rats. Glibenclamide (1.25 mg/kg body weight) was used as a reference drug. For antihyperglycemic evaluation, glucose, C-peptide, Insulin, Hb and glycosylated Hb(HbA1c) levels were analyzed. Low d. lipoprotein (LDL), High d. lipoprotein(HDL), triglycerides and total cholesterol were analyzed in rats. The enzymic antioxidant activity (super oxide dismutase(SOD), glutathione peroxidase(GPx), glutathione S transferase (GST) and Catalase) and non-enzymic antioxidant activity(vitamin C, vitamin E and reduced glutathione) of C. Paniculatum flower were evaluated. Important carbohydrate metabolizing enzymes like Glucose 6-phosphatase, Fructose 1and 6 diphosphatase and hexokinase were determined in exptl. rats. After the oral administration of CPF extract significantly reduced glucose levels and cholesterol values. Extract improved enzymic and non enzymic antioxidant levels. CPF extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetic rats.

Biocatalysis and Agricultural Biotechnology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fialho, David M. published the artcileDepsipeptide nucleic acids: Prebiotic formation, oligomerization, and self-assembly of a new proto-nucleic acid candidate, HPLC of Formula: 19444-84-9, the publication is Journal of the American Chemical Society (2021), 143(34), 13525-13537, database is CAplus and MEDLINE.

The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process remains challenging. Alternatively, RNA may have been preceded by an earlier ancestral polymer, or proto-RNA, that had a greater propensity for self-assembly than RNA, with the eventual transition to functionally superior RNA being the result of chem. or biol. evolution. We report a new class of nucleic acid analog, depsipeptide nucleic acid (DepsiPNA), which displays several properties that are attractive as a candidate for proto-RNA. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these DepsiPNA oligomers are capable of complementary self-assembly and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers on the early earth may have been relatively facile if the constraints of an RNA-first scenario are relaxed.

Journal of the American Chemical Society published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, HPLC of Formula: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jensen, Pernille R. published the artcileVisualization of Pathway Usage in an Extended Carbohydrate Conversion Network Reveals the Impact of Solvent-Enabled Proton Transfer, Synthetic Route of 19444-84-9, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(32), 12270-12276, database is CAplus.

Bio-sourced mols. should increasingly contribute to meeting societal demands for energy and chems., while reducing net carbon dioxide release and the dependence on fossil resources. Especially oxygenated chems. can be derived from carbohydrates, and the conversion of carbohydrates in protic and nonprotic solvents has attracted considerable interest. Here, we probe chemocatalytic carbohydrate conversion in a time-resolved manner using quant. in situ NMR spectroscopy. A core reaction network in the carbohydrate conversion by Sn(IV) in nonprotic solvents is followed by identifying and quant. tracking 10 chems. with more than 70 at. sites. In situ anal. yields nine rate constants and shows that (co)solvents with labile protons strongly affect tautomerization kinetics and product distributions at an upstream branch point of the reaction network. Solvent-enabled tautomerization and the ensuing accumulation of reactive 1,2-dicarbonyl compounds can thus be key factors influencing reaction kinetics and atom economy in carbohydrate conversion. A reaction network for carbohydrate valorization was observed, revealing the impact of solvent protons on the desired process and on aggregation and degradation reactions.

ACS Sustainable Chemistry & Engineering published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Campos Fraga, Mariana Myriam published the artcileFast Pyrolysis Oil Upgrading via HDO with Fe-Promoted Nb₂O₅-Supported Pd-Based Catalysts, Name: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Energies (Basel, Switzerland) (2022), 15(13), 4762, database is CAplus.

Due to the high acid, oxygen and water contents of fast pyrolysis oil, it requires the improvement of its fuel properties by further upgrading, such as catalytic hydrodeoxygenation (HDO). In this study, Nb₂O₅ was evaluated as a support of Pd-based catalysts for HDO of fast pyrolysis oil. A Pd/SiO₂ catalyst was used as a reference Addnl., the impact of iron as a promoter in two different loadings was investigated. The activity of the synthesized catalysts was evaluated in terms of H₂ uptake and composition of the upgraded products (gas phase, upgraded oil and aqueous phase) through elemental anal., Karl Fischer titration, GC-MS/FID and 1H-NMR. In comparison to SiO₂, due to its acid sites, Nb₂O₅ enhanced the catalyst activity toward hydrogenolysis and hydrogenation, confirmed by the increased water formation during HDO and a higher content of hydrogen and aliphatic protons in the upgraded oil. Consequently, the upgraded oil with Nb₂O₅ had a lower average mol. weight and was therefore less viscous than the oil obtained with SiO₂. When applied as a promoter, Fe enhanced hydrogenation and hydrogenolysis, although it slightly decreased the acidity of the support, owing to its oxophilic nature, leading to the highest deoxygenation degree (42.5 weight%) and the highest product HHV (28.2 MJ/kg).

Energies (Basel, Switzerland) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Name: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kravetz, Carolina published the artcileCharacterization of selected pyrolysis products of diseased orange wood, Category: tetrahydrofurans, the publication is BioResources (2020), 15(3), 7118-7126, database is CAplus.

Orange trees in Brazil are often burned as a means of eradication when they become infected with Huanglongbing disease. Rather than destroying them, which is a low-value proposition, one potential option is to utilize the biomass through pyrolysis. In this preliminary work, orange trees (Citrus sinensis) otherwise selected for purging, were sampled and pyrolyzed at 500 °C, and the charcoal and bio-oil were evaluated for potential value-added use. The results showed that the pyrolysis process resulted in 26.3% charcoal, 57.6% bio-oil, and 16.0% non-condensable gases. Qual. anal. of the bio-oil by gas chromatog./mass spectrometry found 178 chem. compounds; however, only 25% of those compounds could be reliably identified. Potential applications of the compounds identified in the bio-oil were determined by examining the published literature, and it was found that at least 73% of them showed promise. Finally, initial studies on the immediate anal. of the pyrolysis charcoal showed that it potentially meets the standards set forth for Brazilian domestic use.

BioResources published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Kun published the artcileChemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues, Application In Synthesis of 57124-87-5, the publication is ChemBioChem (2016), 17(11), 995-998, database is CAplus and MEDLINE.

We report a cysteine-based ligation strategy for generating a monoubiquitylated protein while preserving the native cysteine residues on the acceptor protein. In monoubiquitylation of proliferating cell nuclear antigen (PCNA) this method circumvents the need to mutate the native cysteine residues on PCNA. The chem. ubiquitylated PCNA contains a noncleavable linkage of the same length as the native isopeptide linkage. It also retains the normal function of the native Ub-PCNA in stimulating the ATPase activity of replication factor C (RFC) and lesion bypass synthesis by Polη. This method may be adapted for chem. ubiquitylation of other proteins and for site-specific modification of a target protein at a specific site through sulfhydryl chem.

ChemBioChem published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C9H10F3NO2S, Application In Synthesis of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Yuanyi published the artcileIdentification, quantitation and sensorial contribution of lactones in brandies between China and France, Name: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Food Chemistry (2021), 129761, database is CAplus and MEDLINE.

Lactones are important flavor compounds in lots of foodstuffs. They also play an important role in brandy, but have not been studied at large. In this study, solid-phase extraction (SPE) and stir bar sorptive extraction (SBSE) combined with comprehensive two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC x GC-TOFMS) were applied to identify and quantify lactones in brandies between China and France. Totally 17 lactones were identified, four of which were detected only in SBSE. Among them, γ-valerolactone, γ-heptalactone, δ-octalactone, γ-undecanolactone and δ-dodecalactone were detected in brandy for the first time. The results of partial least squares-discriminant anal. (PLS-DA) revealed that lactones distinguished regional characteristics among different brandies. The omission test showed that four lactones (OAV > 1) had direct impact on the aroma of brandy, and other seven lactones at sub-threshold (0.1 < OAV < 1) provided peach and apricot aroma characteristics through synergistic effects.

Food Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Name: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem