Tag: M.W=100-150

Aldakheel, Reem K. published the artcileBactericidal and in vitro cytotoxicity of Moringa oleifera seed extract and its elemental analysis using laser-induced breakdown spectroscopy, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Pharmaceuticals (2020), 13(8), 193, database is CAplus and MEDLINE.

In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biol. effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract Detailed elemental anal. of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatog.-mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined The bactericidal efficacy of the alc. MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and SEM (SEM), which depicted greater inhibition against Gram-pos. bacteria. The validity and DNA nuclear morphol. of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Addnl., MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chem. complexes, such as Et ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications.

Pharmaceuticals published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Silva, Ramon published the artcileAdvantages of using ohmic heating in Dulce de Leche manufacturing, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Innovative Food Science & Emerging Technologies (2020), 102475, database is CAplus.

Ohmic heating (OH, 0, 2, 4, 6, 8, or 10 V cm-1, 72 °C/15 s, 60 Hz) at Dulce de leche processing was investigated. The equipment consisted in an ohmic heating chamber, and rectangular 316 stainless steel electrodes positioned 10 cm apart. OH-treated milk resulted in improvements in the quality parameters of Dulce de leche, with a decrease in energy expenditure (69.85-141.86 vs 1260 kJ) and hydroxymethylfurfural (HMF) levels (7.64-8.54 vs 9.53 μmol L-1), an increase in product homogeneity, and formation of volatile compounds important for the sweetness of Dulce de leche (butanoic acid and 2-furan methanol). In addition, the physicochem. composition, fatty acid profile, and health indexes (atherogenic, thrombogenic, desired fatty acids, and hypercholesterolemic saturated fatty acids) of the products remained without changes. In particular, the use of higher elec. field (> 6 V cm-1) led to a 14-78% decrease in process time, and improved volatiles profile. OH has proven to be a suitable technol. for milk treatment, resulting in improvements in the quality parameters of Dulce de leche with pos. impact at the process time and energy expenditure. The Dulce de Leche processing is characterized by long cooking times to acquire its typical characteristic color and flavor. Normally, it is used pasteurized milk as raw material. Ohmic heating decreased the total time of processing in Dulce de leche manufacturing, providing an economy at the in the energy costs without significant change at the quality parameters of the final product.

Innovative Food Science & Emerging Technologies published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H16Br3N, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bokov, D. O. published the artcileComparison of the Chemical Compositions of Galanthus woronowii Losinsk. and Galanthus nivalis L. Homeopathic Mother Tinctures by Gas Chromatography with Mass-Selective Detection, Category: tetrahydrofurans, the publication is Pharmaceutical Chemistry Journal (2017), 50(10), 659-667, database is CAplus.

The chem. compositions of homeopathic mother tinctures (HMT) from the two snowdrop species Galanthus woronowii Losinsk. and Galanthus nivalis L. were compared using gas chromatog. with mass-selective detection (GC-MS). A total of 13 compounds were identified in G. woronowii HMT; 42, in G. nivalis HMT. The common constituents of the two tinctures were ethyl-α-D-glucopyranoside, ethyl-α-D-riboside, Et linoleate, and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. The main marker compounds (galantamine and licorine) were determined Their contents were used to standardize the homeopathic drugs.

Pharmaceutical Chemistry Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Langa-Lomba, Natalia published the artcileActivity of Anthracenediones and Flavoring Phenols in Hydromethanolic Extracts of Rubia tinctorum against Grapevine Phytopathogenic Fungi, Application In Synthesis of 19444-84-9, the publication is Plants (2021), 10(8), 1527, database is CAplus and MEDLINE.

In this work, the chem. composition of Rubia tinctorum root hydromethanolic extract was analyzed by GC-MS, and over 50 constituents were identified. The main phytochems. were alizarin-related anthraquinones and flavoring phenol compounds The antifungal activity of this extract, alone and in combination with chitosan oligomers (COS) or with stevioside, was evaluated against the pathogenic taxa Diplodia seriata, Dothiorella viticola and Neofusicoccum parvum, responsible for the so-called Botryosphaeria dieback of grapevine. In vitro mycelial growth inhibition tests showed remarkable activity for the pure extract, with EC50 and EC90 values as low as 66 and 88 μg·mL-1, resp. Nonetheless, enhanced activity was attained upon the formation of conjugate complexes with COS or with stevioside, with synergy factors of up to 5.4 and 3.3, resp., resulting in EC50 and EC90 values as low as 22 and 56 μg·mL-1, resp. The conjugate with the best performance (COS-R. tinctorum extract) was then assayed ex situ on autoclaved grapevine wood against D. seriata, confirming its antifungal behavior on this plant material. Finally, the same conjugate was evaluated in greenhouse assays on grafted grapevine plants artificially inoculated with the three aforementioned fungal species, resulting in a significant reduction in the infection rate in all cases. This natural antifungal compound represents a promising alternative for developing sustainable control methods against grapevine trunk diseases.

Plants published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, Name: 2-Methyl-3-tetrahydrofuranthiol, the publication is Chemical Research in Toxicology (2020), 33(9), 2381-2389, database is CAplus and MEDLINE.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H5N3S, Name: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Deepa, J. published the artcilePreliminary phytochemical screening and GC-MS analysis of methanolic leaf extract of Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim. from Silambur sacred grove, Tamilnadu, Category: tetrahydrofurans, the publication is Journal of Chemical and Pharmaceutical Research (2016), 8(8), 287-291, database is CAplus.

A valuable Indian ethnomedicinal plant, Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim was investigated to determine the phytochem. constituents present in various extracts of the leaves through GC-MS (Gas Chromatog.-Mass Spectrometry) anal. Powd. leaf plant materials were subjected to successive extraction with organic solvents such as methanol by Soxhlet extraction method. In the present study, a total of 23 different compounds identified by GC-MS anal. using methanol extract, all the identified compounds were medicinally valuable for the treatment of various human ailments. In addition, all the phytochem. compounds were needed for further investigations on toxicol. aspects for the development of new lead of therapeutic interest.

Journal of Chemical and Pharmaceutical Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Haijun published the artcileEthanol-Assisted Hydrothermal Liquefaction of Poplar Using Fe-Co/Al₂O₃ as Catalyst, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Energies (Basel, Switzerland) (2022), 15(9), 3057, database is CAplus.

Although the conversion of lignocellulosic biomass into bio-oil with high yield/quality through hydrothermal liquefaction (HTL) is promising, it still faces many challenges. In this study, a Fex-Co(1-x)/Al₂O₃ catalyst was prepared with the coprecipitation method and low-content ethanol was used as the cosolvent for the HTL of poplar. The results showed that the Fex-Co(1-x)/Al₂O₃ catalyst significantly promoted the yield and energy recovery rate (ERR) of bio-oil compared with the control (10% ethanol content). At 260 °C for 30 min, 60Fe-40Co/Al₂O₃ had the best catalytic effect, achieving the highest bio-oil yield (67.35%) and ERR (93.07%). As a multifunctional bimetallic catalyst, Fex-Co(1-x)/Al₂O₃ could not only increase the degree of hydrogenation deoxidization of the product but also promote the diversity of phenolic compounds gained from lignin. The bio-oil obtained from HTL with Fex-Co(1-x)/Al₂O₃ as catalyst contained lower heterocyclic nitrogen, promoting the transfer of more bio-oil components to substances with lower b.p.

Energies (Basel, Switzerland) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C22H18O2, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chakraborty, Amit published the artcileDisulfide-based protecting groups for the cysteine side chain, Formula: C5H10OS, the publication is Organic Letters (2020), 22(24), 9644-9647, database is CAplus and MEDLINE.

Two new disulfide-based protecting groups (SIT and MOT) (I and II) are proposed for Cys thiol in the substitution of StBu, which is often difficult to remove. Both groups are based on a secondary thiol with a branched point in the β-position for an efficient modulation of its lability and/or stability. This unique structure allows them to be fully compatible with Fmoc/tBu SPPS (Fmoc = 9-fluorenylmethoxycarbonyl). At the end of the synthesis, these groups are removed in a straightforward manner with dithiothreitol with some H₂O.

Organic Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Formula: C5H10OS.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xuan, Maojie published the artcileC-S coupling with nitro group as leaving group via simple inorganic salt catalysis, Computed Properties of 57124-87-5, the publication is Chinese Chemical Letters (2020), 31(1), 84-90, database is CAplus.

An efficient and practical synthetic protocol to synthesize non-sym. aryl thioethers by nucleophilic aromatic substitution (S_NAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups were tolerated by the system to provided thioethers in a good to excellent yields. The present method allowed access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggested that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

Chinese Chemical Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C37H30ClIrOP2, Computed Properties of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brzezinska, Jolanta published the artcileNon-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides, Quality Control of 19444-84-9, the publication is Molecules (2015), 20(7), 12652-12669, database is CAplus and MEDLINE.

The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced neg. charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogs built from units that carry different diol structures instead of sugar residues and functionalized with polyamines. The non-nucleosidic analogs were attached as internal or 5′-terminal modifications in oligodeoxyribonucleotide strands. The thermodn. studies of these polyaminooligonucleotide analogs revealed stabilizing or destabilizing effects that depend on the linker or polyamine used.

Molecules published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem