Tag: M.W=100-150

Li, Yuehui published the artcileLewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Angewandte Chemie, International Edition (2015), 54(17), 5196-5200, database is CAplus and MEDLINE.

Ethers are of fundamental importance in organic chem. and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity.

Angewandte Chemie, International Edition published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Binh, Nguyen Tan published the artcileBioactive compounds from marine fungus penicillium citrinum strain ND7c by gas chromatography-mass spectrometry, Quality Control of 19444-84-9, the publication is Pharmaceutical and Chemical Journal (2018), 5(1), 211-224, database is CAplus.

The objectives of this study were anal. of the secondary metabolite products from extract of marine Penicillium citrinum strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Sixteen bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chem. compounds is based on the peak area, retention time, mol. weight and mol. formular. GC-MS anal. of Penicillium citrinum strain ND7a revealed the existence of the 9-Hexadecenoic acid, Hexadecane, n-Hexadecanoic acid, Heptacosane, Octadecane, 3-ethyl-5-(2-ethylbutyl), Tri-Bu acetylcitrate, 17-Pentatriacontene, Hexanedioic acid, bis(2-ethylhexyl) ester, Bis(2-ethylhexyl) phthalate (in organic solvent hexan-aceton) and Oxime-, methoxy-Ph, 2-Hydroxy-gamma-butyrolactone, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, Pentadecanoic acid, 14-methyl-, Me ester, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, Stigmasterol, γ-Sitosterol (in organic solvent aceton-methanol).

Pharmaceutical and Chemical Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spanik, I. published the artcileA comparative study of various sample preparation procedures for characterization of organic compounds in brandy, SDS of cas: 19444-84-9, the publication is Uchenye Zapiski Kazanskogo Universiteta, Seriya Estestvennye Nauki (2014), 156(4), 8-28, database is CAplus.

This paper describes the composition of volatile compounds in 19 different wine distillates was studied by gas chromatog. (GC) coupled with flame ionization (FID) or mass-spectrometric (MS) detector. The studied samples were divided into two groups depending on the way of their production and geog. region. The effect of various sample treatment procedures on final composition of volatiles was investigated in details. The effectiveness of direct injection, headspace, solid phase extraction (SPE), solid phase microextraction (SPME) and liquid-liquid extraction (LLE) was compared. Moreover, the effect of exptl. conditions of preconcentration methods such as type of sorbent, temperature, time or solvent removal procedure was studied in details. The repeatability of particular sample preparation procedure was evaluated by comparison of peak areas for randomly selected compounds obtained from 4 parallel measurements. It was shown that the most suitable sample treatment procedure in terms of repeatability is SPE followed by direct injection and headspace. LLE and SPME provide higher variability of peak areas, thus utilization of internal standard for quantification is recommended. On the contrary, the most suitable sample treatment procedure in terms of the number of different type of compounds is liquid-liquid extraction into CH₂Cl₂. By this method, more than 240 compounds have been extracted from wine distillates produced by classical technol. Furthermore, SPME has shown different selectivity which allows one to determine compounds that could not be extracted by other studied sample preparation methods.

Uchenye Zapiski Kazanskogo Universiteta, Seriya Estestvennye Nauki published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C30H24BrCuN2P, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Zhuo published the artcileAcenaphtho[1,2-b]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity, Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is Journal of Medicinal Chemistry (2011), 54(11), 3732-3745, database is CAplus and MEDLINE.

A novel series of acenaphtho[1,2-b]pyrrole derivatives as potent and selective inhibitors of fibroblast growth factor receptor 1 (FGFR1) were designed and synthesized. In silico target prediction revealed that tyrosine kinases might be the potential targets of the representative compound I, which was subsequently validated by ELISA for its selective and active FGFR1 inhibition of various tyrosine kinases. The structure-activity relationship (SAR) anal. aided by mol. docking simulation in the ATP-binding site demonstrated that acenaphtho[1,2-b]pyrrolecarboxylic acid esters are potent inhibitors of FGFR1 with IC₅₀ values ranging from 19 to 77 nM. Furthermore, these compounds exhibited favorable growth inhibition property against FGFR-expressing cancer cell lines with IC₅₀ values ranging from micromolar to submicromolar. Western blotting anal. showed that three of these compounds inhibited activation of FGFR1 and extracellular-signal regulated kinase 1/2 (Erk1/2).

Journal of Medicinal Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Application of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Wen-peng published the artcileIsolation and identification of three anaerobic bacteria strains in Luzhou-flavor liquor and metabolites analysis, HPLC of Formula: 19444-84-9, the publication is Shipin Keji (2018), 43(2), 15-20, database is CAplus.

In this experiment, anaerobic bacteria were isolated from pit mud under anaerobic condition, and the metabolites were analyzed by GC-MS and through colony morphol. observation, Gram staining, spore staining, biochem. test, phospholipid fatty acid anal. and 16S rDNA identification. Three strains of bacteria were screened, resp. named as SJ-1, SJ-2 and SJ-3. It was obtained from the anal. and identification that SJ-1 is Bacillus liciusiformis, SJ-2 is Bacillus aerius, and SJ-3 is Clostridium butyricum subsp. The results of the fermentation products showed that the main products of the three strains such as butyric acid, n-butanol, acetic acid, 2,3-butanediol that are the skeletal components in the micro components of Luzhou-flavor liquor, Strain SJ-3 had good performance, and its yield of butyric acid was 202.56 mg/mL, indicating that the three strains play a pos. role in the production of flavor substances in the Luzhou-flavor liquor.

Shipin Keji published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C13H11NO, HPLC of Formula: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ni, Zhi-Jing published the artcileAnalysis of key precursor peptides and flavor components of flaxseed derived Maillard reaction products based on iBAQ mass spectrometry and molecular sensory science, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol, the publication is Food Chemistry: X (2022), 100224, database is CAplus and MEDLINE.

Flaxseed derived Maillard reaction products (MRPs) have typical meaty flavor, but there is no report on comparison of their amino acids and peptides reactivity. The peptides and amino acids of flaxseed protein hydrolyzates were sep. collected by G-15 gel chromatog. Taste dilution anal. (TDA) showed that peptides-MRPs had high umami, mouthfulness, and continuity enhancement. Further, LC-MS/MS revealed that flaxseed protein hydrolyzates consumed 41 peptides after Maillard reaction. Particularly, DLSFIP (Asp-Leu-Ser-Phe-Ile-Pro) and ELPGSP (Glu-Leu-Pro-Gly-Ser-Pro) accounted for 42.22% and 20.41% of total consumption, resp. Aroma extract dilution anal. (AEDA) indicated that formation of sulfur-containing flavors was dependent on cysteine, while peptides were more reactive than amino acids for nitrogen-containing heterocycles. On the other hand, 11 flavor compounds with flavor dilution (FD) ≥ 64 were identified for flaxseed derived MRPs, such as 2-methylthiophene, 2-methyl-3-furanthiol, furfural, 2-furfurylthiol, 3-thiophenethiol, thieno[3,2-b] thiophene, 2,5-thiophenedicarboxaldehyde, 2-methylthieno[2,3-b] thiophene, 1-(2-methyl-3-furylthio)-ethanethiol, 2-methylthieno[3,2-b] thiophene, and bis(2-methyl-3-furyl)-disulfide. In addition, we further demonstrated the flavors formation mechanism of flaxseed derived MRPs.

Food Chemistry: X published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dai, Shuiping published the artcileAnalysis and simulation of volatile components of roasted beef, Formula: C5H10OS, the publication is Xiangliao Xiangjing Huazhuangpin (2010), 43-47, database is CAplus.

Applicability of headspace solid-phase microextraction (HS-SPME) combined with gas chromatog. and mass spectrometry (GC-MS) for determination of volatile components in roasted beef was investigated. The 42 volatile components were identified, including carboxylic acid compounds, aldehyde compounds, phenolic compounds, heterocyclic compounds (pyrazine ring, thiazole ring) and alcs. Based on GC-MS anal., realistic and coordinated roasted beef flavor was simulated using sensory anal. And its aroma profile was similar with the roasted beef determined up to 92.4% by electronic nose (E-nose).

Xiangliao Xiangjing Huazhuangpin published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Formula: C5H10OS.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Seow, Yi-Xin published the artcileOdor-specific loss of smell sensitivity with age as revealed by the specific sensitivity test, Synthetic Route of 57124-87-5, the publication is Chemical Senses (2016), 41(6), 487-495, database is CAplus and MEDLINE.

The perception of odor mixtures plays an important role in human food intake, behavior, and emotions. Decline of smell acuity with normal aging could impact food perception and preferences at various ages. However, since the landmark Smell Survey by National Geog., little has been elucidated on differences in the onset and extent of loss in olfactory sensitivity toward single odorants. Here, using the Specific Sensitivity test, we show the onset and extent of loss in both identification and detection thresholds of odorants with age are odorant-specific. Subjects of Chinese descent in Singapore (186 women, 95 men), aged 21-80 years, were assessed for olfactory sensitivity of 10 odorants from various odor groups. Notably, subjects in their 70s required 179 times concentration of rose-like odorant (2-phenylethanol) than subjects in the 20s, while thresholds for onion-like 2-methyloxolane-3-thiol only differed by 3 times between the age groups. In addition, identification rate for 2-phenylethanol was neg. correlated with age throughout adult life whereas mushroom-like oct-1-en-3-ol was equally identified by subjects across all ages. Our results demonstrated the girth of differentiated olfactory loss due to normal ageing, which potentially affect overall perception and preferences of odor mixtures with age.

Chemical Senses published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is CBF6K, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Jinxiang published the artcilePyrolysis volatiles and environmental impacts of printing paper in air, COA of Formula: C4H6O3, the publication is Cellulose (Dordrecht, Netherlands) (2014), 21(4), 2871-2878, database is CAplus.

Pyrolysis volatiles and the environmental impact of printing paper in an air atm. were investigated using pyrolysis-gas chromatog./mass spectrometry and SEM. CO₂ and light-pollution products were found to be the major products from pyrolysis volatiles; furthermore, because oxygen participates in the chem. reaction, many of the pyrolysis volatiles emitted during the paper printing process were different from those formed under an N₂ atmosphere. Although a small number of the volatiles were moderately toxic products, the concentrations of these volatiles were low. Heat-induced inkless eco-printing (HIEP) was found to take less time than the pyrolysis experiment in this paper and thus resulted in fewer pyrolysis volatiles. Thus, fewer pyrolysis volatiles will be emitted within the practical temperature range; in particular, no carcinogens were emitted in the pyrolysis temperature range of 250-700 °C. Therefore, HIEP was found to be an ecol. and environmentally preferable technol.

Cellulose (Dordrecht, Netherlands) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yu, Tzu-Yu published the artcileSafe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C-S Cross-Couplings in Recyclable Water, Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is Angewandte Chemie, International Edition (2021), 60(7), 3708-3713, database is CAplus and MEDLINE.

A new approach to C-S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts.

Angewandte Chemie, International Edition published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C8H8O3, Application of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem