Tag: M.W:0-100

453-20-3, In an article, published in an article,authors is Che, Penghua, once mentioned the application of 453-20-3, Name is 3-Hydroxytetrahydrofuran,molecular formula is C4H8O2, is a conventional compound. this article was the specific content is as follows.

A strategy of ketalization for the catalytic selective dehydration of biomass-based polyols over H-beta zeolite

Biomass contains plentiful hydroxyl groups that lead to an oxygen-rich structure compared to petroleum-based chemicals. Dehydration is the most energy-efficient technique to remove oxygen; however, multiple similar vicinal hydroxyl groups in sugar alcohols impose significant challenges for their selective dehydration. Here, we present a novel strategy to control the etherification site in sugar alcohols by the ketalization of the vicinal-diol group for the highly selective formation of tetrahydrofuran derivatives. A ketone firstly reacts with terminal vicinal hydroxyl groups to form the 1,3-dioxolane structure. This structure of the constrained 1,3-dioxolane ring would improve the accessibility of reactive groups to facilitate intramolecular etherification. As a better leaving group than water, the ketone can also promote intramolecular etherification. Consequently, a range of tetrahydrofuran derivatives are produced in excellent yields with the H-beta zeolite catalyst under mild reaction conditions. This strategy opens up new opportunities for the efficient upgrading of biomass via the modification or protection of hydroxyl groups.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

22929-52-8, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 22929-52-8

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 22929-52-8, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 22929-52-8

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 453-20-3

GPR40 AGONISTS IN ANTI-DIABETIC DRUG COMBINATIONS

Disclosed are compositions comprising (a) a GPR40 agonist and (b) an SGLT2 inhibitor, and methods for treating of disorders that are affected by the modulation of the GPR40 receptor and SGLT2 transporter. Such GPR40 compounds are represented by Formula (I) as follows: wherein ring W, R1, R2, R3, R5, R6, A, and Z, are defined herein.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 453-20-3, name is 3-Hydroxytetrahydrofuran, introducing its new discovery. 453-20-3

CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts thereof, formula (I) are useful as kinase modulators, including Btk modulation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.453-20-3, you can also check out more blogs about453-20-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, Name is 3-Hydroxytetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. 453-20-3In an article, authors is Akar, once mentioned the new application about 453-20-3.

Total Electron Stopping Powers and CSDA-Ranges from 20 eV to 10 MeV Electron Energies for Components of DNA and RNA

An appropriate formula for the total stopping power of electrons of initial kinetic energy from 20 eV to 10 MeV in some biological materials is presented. The continuous slowing down approximation-range (CSDA-range) from the total stopping power is also made. The collisional stopping power formula is evaluated using Generalized Oscillator Strength (GOS) model and exchange correction on the inelastic differential cross section (IDCS) given by [M. Inokuti, Rev. Mod. Phys. 43 (1971) 297-347] and the radiative stopping power formula is calculated from the bremsstrahlung differential cross section (DCS) given by [H.W. Koch, J.W. Motz, Rev. Mod. Phys. 31 (4) (1959) 920-955]. Calculation of the total stopping powers (SPs) and CSDA-range for biological compounds: C5H5N5 (adenine), C5H5N5O (guanine), C4H5N3O (cytosine), C5H6N2O2 (thymine), C4H4N2O2 (uracil), C4H8O (tetrahydrofuran), C4H8O2 (3-hydroxytetrahydrofuran), C5H10O2 (alpha-tetrahydrofurfuryl alcohol), H3PO4 (phosphoric acid), C19H26N8O13P2 (thymine{single bond}adenine{single bond}DNA) have been introduced for incident electrons in the 20 eV-10 MeV energy range. The calculated results have been compared with experimental data, PENELOPE program results and other theoretical results. The calculated results of total stopping power and CSDA-ranges for electrons in energy range from 20 eV to 10 MeV are found to be in good agreement to within 8% with available data.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3, An article , which mentions 453-20-3, molecular formula is C4H8O2. The compound – 3-Hydroxytetrahydrofuran played an important role in people’s production and life.

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria

PlsY is the essential first step in membrane phospholipid synthesis of Gram-positive pathogens. PlsY catalyzes the transfer of the fatty acid from acyl-phosphate to the 1-position of glycerol-3-phosphate to form the first intermediate in membrane biogenesis. A series of non-metabolizable, acyl-sulfamate analogs of the acyl-phosphate PlsY substrate were prepared and evaluated as inhibitors of Staphylococcus aureus PlsY and for their Gram-positive antibacterial activities. From this series phenyl (8-phenyloctanoyl) sulfamate had the best overall profile, selectively inhibiting S. aureus phospholipid biosynthesis and causing the accumulation of both long-chain fatty acids and acyl-acyl carrier protein intermediates demonstrating that PlsY was the primary cellular target. Bacillus anthracis was unique in being more potently inhibited by long chain acyl-sulfamates than other bacterial species. However, it is shown that Bacillus anthracis PlsY is not more sensitive to the acyl-sulfamates than S. aureus PlsY. Metabolic profiling showed that B. anthracis growth inhibition by the acyl-sulfamates was not specific for lipid synthesis illustrating that the amphipathic acyl-sulfamates can also have off-target effects in Gram-positive bacteria. Nonetheless, this study further advances PlsY as a druggable target for the development of novel antibacterial therapeutics, through the discovery and validation of the probe compound phenyl (8-phenyloctanoyl) sulfamate as a S. aureus PlsY inhibitor.

453-20-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 453-20-3

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To (2-bromo-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)(4,7,difluoro- 1 H-indol-2-yl)methanone (0.030 g, 0.753 mmol) was added tetrahydrofuran-3-amine (1.0 ml, 5.81 mmol). The mixture was stirred at 80¡ãC for 7 days. The mixture was cooled, then purified directly by basic reverse phase HPLC to give the desired product (0.114 g, 35percent yield)Rt (Method A) 3.15 mins, m/z 405 [M+H]., 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; AICURIS GMBH & CO. KG; DONALD, Alastair; URBAN, Andreas; BONSMANN, Susanne; WEGERT, Anita; GREMMEN, Christiaan; SPRINGER, Jasper; (376 pag.)WO2019/86141; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.

Description 20 : Dihydro-3(2H)-furanone; A mixture of 3-hydroxytetrahydrofuran (3.0 g, 0.034 mol) and pyridinium chlorochromate (14.7 g, 0.068 mol) in DCM (100 ml) was stirred at room temperature overnight. The title product was obtained by pouring the crude product through a silica pad using ethyl acetate as the eluent. The title product was obtained from 2 elutions (2.29 g; 79percent). 1H NMR (CDCI3) delta: 2.50 (2H, t), 3.87 (2H, s), 4.26 (2H, t).

453-20-3, 453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/67430; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

453-20-3,453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Pyridinium chlorochromate (6.5 g, 30 mmol, 1.5 equiv) was dissolved in 100 ml DCM at rt. Tetrahydro-3-furanol (1.6 ml, 20 mmol, 1 equiv) was added dropwise. 4 A molecular sieves (16 g) and glacial acetic acid (2 ml) were respectively added. The reaction mixture was stirred at rt overnight. A generous amount of Celite ? 545 was added and the solvent was removed by reduced pressure. The residue was then passed through a Celite ? 545 plug (10percent dichloromethane/diethyl ether) and the solvent was removed in vacuo. The residue was then purified by flash column chromatography (10percent dichloromethane/diethyl ether) to afford 3.45 (60percent yield). Spectral data correspond to that reported.24 1H NMR (400 MHz, CDCI3): delta 4.24 (t, J = 7.3 Hz, 2 H), 3.86 (s, 2 H), 2.48 (t, J = 7.3 Hz, 2 H).

As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.

Reference£º
Patent; THE GOVERNORS OF THE UNIVERSITY OF ALBERTA; HALL, Dennis; GODBOUT, Roseline; KWOK, Samantha; (121 pag.)WO2018/132905; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

Lithium l-benzyl-2-(l,5-dimethyl-6-oxo-l,6-dihydropyridin-3-yl)-lH-imidazole-4- carboxylate (for an example preparation, see Intermediate 13, 10 mg, 0.030 mmol) was added to a vial containing a stirrer bar, and dissolved in DMF (0.25 mL). HATU (12.70 mg, 0.033 mmol) was added, and the reaction mixture stirred under an atmosphere of nitrogen at RT for lh. A solution of rac-tetrahydrofuran-3-amine (5.29 mg, 0.061 mmol) and DIPEA (10.61 muIota, 0.061 mmol) in DMF (0.25 mL) was added, and the reaction stirred for a further lh. The sample was diluted to 0.9 mL with methanol and purified by MDAP (Method B). The solvent was evaporated in vacuo to give the title compound as a colourless oil (8.0 mg, 0.02 mmol, 67percent). LCMS (System B): tRET = 0.75 min; MH+ 393., 88675-24-5

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; BAXTER, Andrew; BIT, Rino, Antonio; BROWN, John, Alexander; HIRST, David; HUMPHREYS, Philip; JONES, Katherine, Louise; PATEL, Vipulkumar, Kantibhai; (124 pag.)WO2018/41964; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem