With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.915095-89-5,(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran,as a common compound, the synthetic route is as follows.
915095-89-5, Under a nitrogen atmosphere, dry THF (60 mL) was added to a 500 mL three-neck flask, cooled to -10C, n-BuMgCl¡¤LiCl in THF (27.2 mL, 27.2 mmol) and a n-BuLi solution in n-hexane were added ( 21.8 mL, 54.4 mL), stirring for 10 min.(S)-4-Bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)benzene (10.0 g, 27.2 mmol) was dissolved in dry THF (20 mL) and slowly added dropwise The reaction solution was maintained at -10C and the reaction was stirred for 2.0 h.After the reaction was completed, a solution of 2,3,4,6-tetraacetoxy-alpha-D-glucopyranose bromide (3.0 g, 6.2 mmol) in THF (20 mL) was slowly added dropwise, and the reaction was continued at -10 C. for 3.0 h. After the reaction was completed, a solution of methanesulfonic acid (9.3 mL) in methanol (80 mL) was added and the temperature was raised to 25 C. for 18.0 h.Adjust the pH to about 7 with saturated NaHCO3 solution and extract twice with EA (100 mL).The organic phase was washed successively with water (100 mL) and saturated NaCl solution (100 mL). Anhydrous MgSO4 was added and the mixture was filtered. The filtrate was concentrated to dryness under reduced pressure to give a pale yellow oil III (15.6 g). The yield was 92.6%.
The synthetic route of 915095-89-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; China Pharmaceutical Group Sichuan Antibiotic Industry Institute; Shi Kejin; Chen Lin; Li Jianghong; Gou Xiaojun; Ren Fengying; Yang Chen; (8 pag.)CN107556302; (2018); A;,
Tetrahydrofuran – Wikipedia
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