79-50-5, 3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,79-50-5
A mixture of 29.5 g of pantolactone, 300 mg of ruthenium (III) chloride, 400 ml of water and 200 ml of ethyl acetate was heated with stirring to reflux temperature by applying a microwave field generated from a microwave reactor (Ethos 1600, available from MLS GmbH, D-88299 Leutkirch im Allgau, Germany) having a power output of 700 W. 145.5 g of sodium (meta) periodate were added to the boiling mixture within 10 minutes. The reaction mixture was then stirred for a further 20 minutes and thereafter rapidly cooled. The organic phase was separated from the aqueous phase and the sodium iodate precipitate in the former phase filtered off by suction and washed five times with 20 ml quantities of ethyl acetate. The two-phase mixture was separated and the aqueous phase extracted twice with 50 ml of ethyl acetate. The combined organic phases were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure. Ketopantolactone was thus obtained in a purity of 98% and a yield of 60% based on starting pantolactone. From the aqueous phase an additional 12% of product could be isolated. Unreacted pantolactone was recovered from the aqueous phase. Following this procedure an 80% conversion of the starting pantolactone into ketopantolactone and a selectivity of 0.95 could be achieved.
The synthetic route of 79-50-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ROCHE VITAMINS AG; WO2003/91235; (2003); A1;,
Tetrahydrofuran – Wikipedia
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