Tag: 425.9097

Development and validation of new RP-HPLC method for the estimation of alfuzosin hydrochloride in bulk and tablet dosage form was written by Patil, Vandana P.;Devdhe, Subhash J.;Kale, Suwarna H.;Nagmoti, Vijay J.;Kurhade, Sadanand D.;Girbane, Yuvraj R.;Gaikwad, Mahesh T.. And the article was included in American Journal of Analytical Chemistry in 2013.Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:

A reverse phase high performance liquid chromatog. method HPLC has been developed for the estimation of Alfuzosin hydrochloride ALH in the pharmaceutical formulation using RP-C18 column. The mobile phase Tetrahy-drofuran, Acetonitrile and buffer pH 3.50 was pumped at a flow rate of 1.5 mL/min in the ratio of 1:20:80 and the eluents were monitored at 254.0 nm. Linearity was obtained in the concentration range of 80 – 120 μg/mL for ALH. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and preci-sion of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determination of Alfuzosin hydrochloride in bulk drugs and in pharmaceutical dosage form. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Development and validation of first order derivative spectrophotometric method for estimation of alfuzosin hydrochloride and finasteride in combined dosage form was written by Patel, Pinal;Patel, Dhara;Desai, Sharav. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2015.Application of 81403-68-1 This article mentions the following:

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of alfuzosin hydrochloride and finasteride in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their resp. zero crossing point (ZCP). The first order derivative spectra were obtained in methanol and the determinations were made at 258 nm for alfuzosin hydrochloride and 223 nm for finasteride. The linearity was obtained in the concentration range of 2-12 μg/mL for both alfuzosin hydrochloride and finasteride. The mean % recovery was 100.79 and 99.89 % for alfuzosin hydrochloride and finasteride resp. The method was found to be simple, sensitive, accurate, precise and was applicable for the simultaneous determination of alfuzosin hydrochloride and finasteride in tablet dosage form. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Application of 81403-68-1).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Application of 81403-68-1

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spectrofluorimetric method for the determination of alfuzosin and flavoxate hydrochlorides in pharmaceuticals and biological fluids was written by Razeq, Sawsan A.. And the article was included in Egyptian Journal of Analytical Chemistry in 2008.Electric Literature of C19H28ClN5O4 This article mentions the following:

A simple and sensitive spectrofluorimetric method was developed to determine alfuzosin-HCl and flavoxate-HCl. Maximum fluorescence intensity was achieved in pure water at 388 nm and 375 nm using λex 244 nm and 240 nm for alfuzosin-HCl and flavoxate-HCl, resp. The optimum exptl. parameters such as solvent, micelle-enhancement, and pH were evaluated. Good correlations were obtained between the fluorescence intensity and concentration in the ranges of 2.5-30 ng/mL for alfuzosin and 1-6 μg/mL for flavoxate-HCl. The suggested method was successfully applied to estimate the 2 drugs in their tablets with average recoveries of 99.2 and 99.8%, resp. These results were found to agree with those of reference methods. The method also retained its accuracy and precision when applied to determine alfuzosin-HCl in spiked blood serum or urine as judged by an average recovery of 95.4 or 100.1%, resp. Furthermore, the method was validated according to the International Conference on Harmonization. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Electric Literature of C19H28ClN5O4).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Electric Literature of C19H28ClN5O4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alfuzosin: an α₁-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia was written by Elhilali, Mostafa M.. And the article was included in Expert Opinion on Pharmacotherapy in 2006.Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:

α₁-Receptor blockers have become first-line therapy for the medical management of lower urinary tract symptoms associated with benign prostatic hyperplasia. However, adverse effects such as cardiovascular intolerance can limit their use. This article focuses on alfuzosin, a clin. uroselective, α₁-adrenergic antagonist that is available as a novel once-daily formulation that does not require dose titration Alfuzosin is less vasoactive than other non-subtype selective α₁-receptor blockers. In addition to effects on lower urinary tract symptoms, it is also used as an adjunct to urethral catheterisation in patients with acute urinary retention related to benign prostatic hyperplasia, and can improve sexual function and health-related quality of life in benign prostatic hyperplasia sufferers. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A validated potentiometric method for determination of alfuzosin hydrochloride in pharmaceutical and biological fluid samples was written by El Badry Mohamed, Marwa;Frag, Eman Y.;Gamal Eldin, Yasmin M.. And the article was included in Journal of the Iranian Chemical Society in 2020.HPLC of Formula: 81403-68-1 This article mentions the following:

Recently, graphene nanosheet has attracted the most attention for the potential applications in various electrochem. sensing fields to biomedical diagnosis and therapy due to its large theor. sp. surface area, unique phys. and elec. properties. In this paper, a newly sensitive and selective modified carbon paste electrodes (MCPEs) were developed for the determination of alfuzosin hydrochloride (ALF.HCl) in pharmaceutical preparation and biol. fluid samples. The paste of these sensors was prepared by mixing alfuzosin phosphomolybdate (ALF-PMA) and alfuzosin tetraphenylborate (ALF-TPB) ion pairs as recognition reagents with different supporting matrixes including graphite powder alone or different ratios of graphite to graphene powders and plasticizer of a relatively high dielec. constant The sensor prepared based on graphite alone as a supporting matrix gave Nernstian slope values of 56.7 ± 0.75 and 51.1 ± 1.11 mV decade-1 for electrode modified with ALF-PMA and ALF-TPB ion pairs, resp., in the concentration range from 1.0 x 10-5 to 1.0 x 10-2 mol L-1 at 25 °C, and the response of the electrode was found to be independent on pH in the range of 2.0-5.0. The Nernstian slope for ALF-TPB modified carbon paste electrode was improved to be 55.8 ± 1.07 mV decade-1 upon mixing graphene with graphite in the paste and showed pH independence in the range of 2.0-6.0. The proposed sensors were successfully applied for the determination of ALF. HCl in pure, biol. fluid samples and pharmaceutical preparation using the direct potentiometric and standard addition methods. Finally, the results obtained using the proposed sensors were compared with those from the official method. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1HPLC of Formula: 81403-68-1).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.HPLC of Formula: 81403-68-1

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Development and characterization of pH-sensitive pectin/acrylic acid hydrogels for colon specific drug delivery was written by Javaid, Zeeshan;ul Rahman, Nisar;Ranjha, Nazar M.;Razzaq, Abida;Ali, Liaqat;Ahmad, Jawad. And the article was included in Latin American Journal of Pharmacy in 2012.Category: tetrahydrofurans This article mentions the following:

The present work was aimed to rationally design and synthesizes pH-sensitive crosslinked pectin/acrylic acid hydrogels for studying release pattern of alfuzosin HCl. Such hydrogels were prepared through free radical polymerizations Then these materials were used as model systems to envisage various important characterizations like Fourier Transform IR Spectroscopy (FTIR), X-ray Diffraction (X-RD), SEM (SEM) and thermal anal. In vitro release pattern of alfuzosin HCl was investigated in buffer solutions of pH 12, 5.5 and 7.5. The release kinetics was evaluated by applying zero order, first order, Higuchi and Peppas kinetic models. Dynamic and equilibrium swelling anal. was performed to predict release behavior and releasing site. Remarkable swelling was observed at higher pH values. FTIR spectra showed intensity of esterified carboxyl group at 1755.92 cm^-1, which is of pure pectin, shifted to lower frequency indicating interaction between pectin and acrylic acid. Thermo gravimetric anal. indicated increase in thermal stability while Differential Scanning Calorimetry (DSC) results showed increase in enthalpy after copolymerization The release of drug followed zero order and exhibited non-fickian diffusion mechanism. As maximum of the drug released at pH 7.5, it depicts the character of this developed polymer as a suitable candidate for colon specific drug delivery. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Category: tetrahydrofurans).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spectrophotometric determination of alfuzocin hydrochloride in pure form and in pharmaceutical formulations by using Folin-Ciocalteu reagent and potassium ferricyanide was written by Krishna, Marothu Vamsi;Sankar, Dannana Gowri. And the article was included in Acta Ciencia Indica, Chemistry in 2006.Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:

Two accurate, simple and precise spectrophotometric methods (1 and 2) are described for the determination of alfuzocin-HCl (AFZ) in bulk and in pharmaceutical formulations. Method 1 was based on the reduction of Folin-Ciocalteu reagent by AFZ, in presence of sodium hydroxide. The colored species formed shows absorption maximum at 760 nm. Method 2 was based on the oxidation of AFZ by ferric chloride in the presence of potassium ferricyanide. The colored complex formed was measured at 750 nm. The optimum exptl. parameters for the color production are selected. Beer’s law is valid with in a concentration range of 50-250 μg mL^-1 for method 1 and 8.0-40.0 μg mL^-1 for method 2. The results obtained were reproducible and statistically validated and found to be suitable for the assay of alfuzocin. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Development and characterization of pH-sensitive pectin/acrylic acid hydrogels for colon specific drug delivery was written by Javaid, Zeeshan;ul Rahman, Nisar;Ranjha, Nazar M.;Razzaq, Abida;Ali, Liaqat;Ahmad, Jawad. And the article was included in Latin American Journal of Pharmacy in 2012.Category: tetrahydrofurans This article mentions the following:

The present work was aimed to rationally design and synthesizes pH-sensitive crosslinked pectin/acrylic acid hydrogels for studying release pattern of alfuzosin HCl. Such hydrogels were prepared through free radical polymerizations Then these materials were used as model systems to envisage various important characterizations like Fourier Transform IR Spectroscopy (FTIR), X-ray Diffraction (X-RD), SEM (SEM) and thermal anal. In vitro release pattern of alfuzosin HCl was investigated in buffer solutions of pH 12, 5.5 and 7.5. The release kinetics was evaluated by applying zero order, first order, Higuchi and Peppas kinetic models. Dynamic and equilibrium swelling anal. was performed to predict release behavior and releasing site. Remarkable swelling was observed at higher pH values. FTIR spectra showed intensity of esterified carboxyl group at 1755.92 cm^-1, which is of pure pectin, shifted to lower frequency indicating interaction between pectin and acrylic acid. Thermo gravimetric anal. indicated increase in thermal stability while Differential Scanning Calorimetry (DSC) results showed increase in enthalpy after copolymerization The release of drug followed zero order and exhibited non-fickian diffusion mechanism. As maximum of the drug released at pH 7.5, it depicts the character of this developed polymer as a suitable candidate for colon specific drug delivery. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Category: tetrahydrofurans).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spectrophotometric determination of alfuzocin hydrochloride in pure form and in pharmaceutical formulations by using Folin-Ciocalteu reagent and potassium ferricyanide was written by Krishna, Marothu Vamsi;Sankar, Dannana Gowri. And the article was included in Acta Ciencia Indica, Chemistry in 2006.Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:

Two accurate, simple and precise spectrophotometric methods (1 and 2) are described for the determination of alfuzocin-HCl (AFZ) in bulk and in pharmaceutical formulations. Method 1 was based on the reduction of Folin-Ciocalteu reagent by AFZ, in presence of sodium hydroxide. The colored species formed shows absorption maximum at 760 nm. Method 2 was based on the oxidation of AFZ by ferric chloride in the presence of potassium ferricyanide. The colored complex formed was measured at 750 nm. The optimum exptl. parameters for the color production are selected. Beer’s law is valid with in a concentration range of 50-250 μg mL^-1 for method 1 and 8.0-40.0 μg mL^-1 for method 2. The results obtained were reproducible and statistically validated and found to be suitable for the assay of alfuzocin. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Quality Control of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem