Tag: 4100-80-5

4100-80-5, 3-Methyldihydrofuran-2,5-dione is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4100-80-5

The starting material is prepared as follows: The mixture of 28.5 g of 2-methylsuccinic anhydride, 23.5 g of 4-aminopyridine and 350 ml of xylene is refluxed on a water separator while stirring for 3.5 hours. The hot solution is decanted from some gummy residue, cooled, filtered, the residue suspended in 100 ml of boiling isopropanol and filtered off again, to yield the 3-methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 119¡ã-120¡ã. The mixture of 34.6 g thereof, 9 g of 10percent palladium on carbon and 400 ml of glacial acetic acid is hydrogenated at 110¡ã C. and approximately 1.7 atm. until the theoretical amount of hydrogen has been absorbed. The mixture is filtered, evaporated and the residue taken up in water. The pH of the mixture is adjusted to 9-10 with sodium carbonate and the liberated base extracted with methylene chloride. The extract is dried and evaporated, to yield the 3-methyl-1-(4-piperidinyl)-pyrrolidin-2,5-dione, which is used directly without further purification.

4100-80-5 3-Methyldihydrofuran-2,5-dione 20051, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; Ciba-Geigy Corporation; US4255429; (1981); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

4100-80-5, 3-Methyldihydrofuran-2,5-dione is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 13 (0.06 mmol) with DMAP (1 equiv) and an appropriate acid anhydride (10 equiv) in anhydrous pyridine(10 ml) was stirred at 155 C for 2 h in a microwave oven (Biotage). The reaction mixture was diluted with EtOAc and neutralized with HCl (1 N) and then extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, and concentrated in vacuum to afford the crude product, followed by chromatographyon a silica gel column and recrystallization to give13e-m.

4100-80-5 3-Methyldihydrofuran-2,5-dione 20051, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Wu, Haifeng; Ma, Guoxu; Yang, Qinwen; Zhu, Yindi; Huang, Li; Tian, Yu; Yang, Xiaoming; Zhang, Menghan; Chen, Chin-Ho; Morris-Natschke, Susan L.; Yang, Meihua; Xu, Xudong; Lee, Kuo-Hsiung; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 159 – 166;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem