Tag: 367.1602

Laser excited Raman spectra of poly(cytidylic acid) was written by Aylward, N. N.;Koenig, J. L.. And the article was included in Macromolecules in 1970.HPLC of Formula: 6757-06-8 This article mentions the following:

The Raman spectra of poly(cytidylic acid), cytidine 5′-monophosphate, deoxycytidine, deoxycytidine 5′-monophosphate, cytidine 3′-phosphate, and cytidine 2′,3′-diphosphate were obtained. By comparing the spectra of the solid state and aqueous solution at various pH values, a qual. anal. of the vibrational modes responsible for various spectral lines is made and small variations are detected which may reflect base stacking. Perturbations of the frequencies of poly(cytidylic acid) on lowering the pH to 5.5 are probably caused by the contiguity of the bases in the hemiprotonated double-helical conformation. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8HPLC of Formula: 6757-06-8).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.HPLC of Formula: 6757-06-8

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A proposal for a specific double-helical structure in which the polynucleotide strands intercalate instead of forming base-pairs was written by Viswamitra, M. A.;Pandit, J.. And the article was included in Journal of Biomolecular Structure & Dynamics in 1983.Category: tetrahydrofurans This article mentions the following:

A double-stranded helical DNA structure without any base pairs, but having a repeat unit of 2 nucleotides with their bases stacked through intercalation, is proposed. The proposal comes from the initial models built for poly(dC) by using the stacking patterns found in the crystal structures of 5′-dCMP-Na₂ which crystallizes in 2 forms depending on the degree of hydration. These structures have pairs of nucleotides with the cytosine rings partially overlapping and separated by 3.3 Å. By using these as repeat units, one could generate a model for poly(dC) with parallel strands, having a turn angle of 30° and a base separation of 6.6 Å along each strand. Both right- and left-handed models with these parameters can be built in a smooth fashion without any obviously unreasonable stereochem. contacts. The helix diameter is ∼13.5 Å, much smaller than that of normal helixes with base-pair repeats. The changes in the sugar-phosphate backbone conformation in the present models compared to normal duplexes only reflect the torsional flexibility available for extension of polynucleotide chains as manifested by the crystal structures of drug-inserted oligonucleotide complexes. Intercalation proposed here could have some structural relevance elsewhere, e.g. to the base-mismatched regions on the double helix and the packing of noncomplementary single strands in the filamentous bacteriophage Pf1. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Category: tetrahydrofurans).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Differential acidimetric determination of the components of nucleic acids, their derivatives, and mixtures in a methyl cellosolve medium was written by Veveris, A.;Spince, B.;Smolova, N. T.. And the article was included in Zhurnal Analiticheskoi Khimii in 1981.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate This article mentions the following:

The proton-acceptor properties of many purine and pyrimidine amino derivatives were examined in methyl cellosolve (MC). Dissociation constant values indicate that in spite of many H⁺-acceptor groups in these derivatives (NH₂, heterocyclic N), these compounds are protonated in MC and H₂O as monobasic compounds (except 6-histaminopurine). H⁺ may be attached to different groups depending on the structure of these derivatives In cytidine, the protonation is at the heterocyclic N at position 3, and adenosine and guanosine with different heterocycles are protonated at 1 (in pyrimidine) and 7 (in imidazole, resp.). The differences in the dissociation constants were large for cytosine and guanosine derivatives Procedures were developed for differential titrimetric procedures for these compounds in binary and ternary mixtures with HClO₄ in MC. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Biochemical studies of taste sensation. IX. Enhancement of L-[³H]-glutamate binding to bovine taste papillae by 5′-ribonucleotides was written by Torii, Kunio;Cagan, Robert H.. And the article was included in Biochimica et Biophysica Acta, General Subjects in 1980.COA of Formula: C9H12N3Na2O8P This article mentions the following:

Binding of tritium-labeled L-glutamate [56-86-0] was measured to preparations of bovine circumvallate (taste) papillae (type I preparation) and to control tongue epithelial preparations (type II preparation) devoid of taste receptors. Substantially greater binding occurred to the type I preparation than to the type II preparation, and the binding to the type I preparation showed evidence of saturation The apparent K_d of L-glutamate was 20-30 mM. A several-fold enhancement of binding of L-glutamate-³H occurred in the presence of certain 5′-ribonucleotides. 5′-GMP di-Na salt [5550-12-9], 5′-IMP di-Na salt [4691-65-0], and 5′-UMP di-Na salt [3387-36-8] each increased the binding of L-glutamate-³H, whereas 5′-XMP di-Na salt [25899-70-1], 5′-AMP di-Na salt [4578-31-8], and 5′-CMP di-Na salt [6757-06-8] did not. None of these nucleotides affected the lower level of binding to the type II preparation Neither the free bases, adenine [73-24-5] and guanine [73-40-5], their nucleosides nor their di- or triphosphononucleotides were effective in increasing L-glutamate-³H binding to the type I preparation The nucleotide specificity of the glutamate binding enhancement therefore shows a marked similarity with the nucleotide specificity in evoking the synergistic taste effect in humans. Using 5′-GMP stimulation as a model, it appeared that the major effect was to increase the maximum binding of L-glutamate-³H, but no marked change in K_d was apparent. The 5′-ribonucleotide may act to increase the extent of L-glutamate binding by unmasking previously hidden or buried receptor sites for L-glutamate. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8COA of Formula: C9H12N3Na2O8P).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C9H12N3Na2O8P

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Matrix-assisted laser desorption/ionization matrices for negative mode metabolomics was written by Fagerer, Stephan R.;Nielsen, Simone;Ibanez, Alfredo;Zenobi, Renato. And the article was included in European Journal of Mass Spectrometry in 2013.Electric Literature of C9H12N3Na2O8P This article mentions the following:

Matrix-assisted laser desorption/ionization (MALDI) has been shown to be highly sensitive for analyzing low-mass compounds such as metabolites if the right matrix is used. 9-Aminoacridine (9AA) is the most commonly employed matrix for neg. mode MALDI-MS in metabolomics. However, matrix interferences and the strongly varying sensitivity for different metabolites make a search for alternative matrixes desirable, in order to identify compounds with a different chem. background and/or favoring a different range of analytes. We tested the performance of a series of potential neg. mode MALDI matrixes with a mix of 29 metabolites containing amino acids, nucleotide phosphates and Krebs cycle intermediates. While ethacridine lactate was found to provide limits of detection (LODs) in the low femtomole range for nucleotide phosphates, amino acids and Krebs cycle intermediates in the low picomole range, 4-amino-2-methylquinoline showed LODs in the picomole range for most metabolites, but is capable of ionizing a broader range of analytes than both 9AA and ethacridine. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Electric Literature of C9H12N3Na2O8P).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C9H12N3Na2O8P

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Raman spectral studies of nucleic acids and related molecules. I. Ribonucleic acid derivatives was written by Lord, Richard C.;Thomas, George J. Jr.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1967.Computed Properties of C9H12N3Na2O8P This article mentions the following:

Raman spectra of the commonly occurring purine and pyrimidine derivatives of ribonucleic acid are reported. The free bases, nucleosides, 5′-mononucleotides, and related alkyl derivatives have been examined in aqueous solutions over wide pH and pD ranges as well as in the solid state. The ir spectra of the solids, some not previously reported, are also included. The spectra are discussed in terms of the changes in mol. structure produced by changes in pH, pD, and state of aggregation. This discussion is intended to serve as a basis for further investigation of intermol. interactions of nucleic acid derivatives in aqueous solution The Raman effect appears to offer much promise for this kind of study. 26 references. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Computed Properties of C9H12N3Na2O8P).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Computed Properties of C9H12N3Na2O8P

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fast atom bombardment tandem mass spectrometry in the identification of isomeric ribomononucleotides was written by Ghosh, D.;Newton, R. P.;Brenton, A. G.;Harris, F. M.;Donovan, M. P.;Brown, E. G.;Walton, T. J.. And the article was included in Analytica Chimica Acta in 1991.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate This article mentions the following:

Anal. of isomeric ribomononucleotides by pos.-ion fast atom bombardment tandem mass spectrometry is described. Daughter ion spectra generated by collision-induced dissociation-mass-analyzed ion kinetic energy scanning on a sector instrument are compared with daughter ion spectra from a triple quadrupole mass spectrometer, and criteria are established for the differentiation of th 2′,3′- and 5′-monophosphate isomers of adenosine, guanosine and cytosine, based on their characteristic fragmentation patterns. The value of tandem mass spectrometry in the identification of nucleotides extracted from biol. systems and isolated by HPLC and in the study of nucleotide metabolism is discussed. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fast atom bombardment tandem mass spectrometry in the identification of isomeric ribomononucleotides was written by Ghosh, D.;Newton, R. P.;Brenton, A. G.;Harris, F. M.;Donovan, M. P.;Brown, E. G.;Walton, T. J.. And the article was included in Analytica Chimica Acta in 1991.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate This article mentions the following:

Anal. of isomeric ribomononucleotides by pos.-ion fast atom bombardment tandem mass spectrometry is described. Daughter ion spectra generated by collision-induced dissociation-mass-analyzed ion kinetic energy scanning on a sector instrument are compared with daughter ion spectra from a triple quadrupole mass spectrometer, and criteria are established for the differentiation of th 2′,3′- and 5′-monophosphate isomers of adenosine, guanosine and cytosine, based on their characteristic fragmentation patterns. The value of tandem mass spectrometry in the identification of nucleotides extracted from biol. systems and isolated by HPLC and in the study of nucleotide metabolism is discussed. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem