Tag: 2399-48-6

2399-48-6, (Tetrahydrofuran-2-yl)methyl acrylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a 0.52 mL microwave vial were added TPT-MeOH (100 mg, 0.30 mmol),n-BuA (0.43 mL, 3.0 mmol), and 1,4-dioxane (1.2 mL), and then the vial was sealed. The mixture was stirred and heated at 140 C under microwave irradiation for 2 h. The Kugelrohr distillation under reduced pressure (1 mmHg, 200 C) gave the product (Entry 16, 259 mg, 69% yield) as a transparent liquid.

As the paragraph descriping shows that 2399-48-6 is playing an increasingly important role.

Reference£º
Article; Matsuoka, Shin-Ichi; Nakazawa, Masanori; Suzuki, Masato; Bulletin of the Chemical Society of Japan; vol. 88; 8; (2015); p. 1093 – 1099;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2399-48-6,(Tetrahydrofuran-2-yl)methyl acrylate,as a common compound, the synthetic route is as follows.

To the 20 mL reaction tube was added 112 mg (0.5 mmol) of compound dibenzoylmethane, 7 mg (0.025 mmol) of K2CO3, 147 muL (1 mmol) of tetrahydrofurfural acrylate and 0.5 mL of tetrahydrofurfuryl alcohol at a temperature of 85 C The reaction was stirred for 24 hours and cooled to room temperature (18-25 C) and transferred to a small flask of 10 mL. The solvent was distilled off under reduced pressure and then passed through a column of neutral alumina. The developing solvent used was petroleum ether: ethyl acetate= 13: 1 to 4: 1 to give compound III-16 126 mg in 91% yield

The synthetic route of 2399-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Southwest University; Cai Guixin; Wen Jing; (13 pag.)CN105061125; (2017); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem