Tag: 235.2425

Chemoenzymatic Syntheses and Anti-HIV-1 Activity of Glucose-Nucleoside Conjugates as Prodrugs was written by Rodriguez-Perez, Tatiana;Fernandez, Susana;Sanghvi, Yogesh S.;Detorio, Mervi;Schinazi, Raymond F.;Gotor, Vicente;Ferrero, Miguel. And the article was included in Bioconjugate Chemistry in 2010.Application of 4097-22-7 This article mentions the following:

Phosphodiester linked conjugates of various nucleosides such as d4U, d4T, IdUrd, ddI, ddA, virazole, ara-A, and ara-C containing a glucosyl moiety have been described. These compounds were designed to act as prodrugs, where the corresponding 5′-monophosphates may be generated intracellularly. The synthesis of the glycoconjugates was achieved in good yields by condensation of a glucosyl phosphoramidite with nucleosides in the presence of an activating agent. It was demonstrated that the glucose conjugates improve the water solubility of the nucleoside analogs, for example, up to 31-fold for the ara-A conjugate compared to that of ara-A alone. The new conjugates were tested for their anti-HIV-1 activity in human lymphocytes. These derivatives offer a convenient design for potential prodrug candidates with the possibility of improving the physicochem. properties and therapeutic activity of nucleoside analogs. In the experiment, the researchers used many compounds, for example, ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7Application of 4097-22-7).

((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Application of 4097-22-7

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new adenylyl cyclase, putative disease-resistance RPP13-like protein 3, participates in abscisic acid-mediated resistance to heat stress in maize was written by Yang, Hao;Zhao, Yulong;Chen, Ning;Liu, Yanpei;Yang, Shaoyu;Du, Hanwei;Wang, Wei;Wu, Jianyu;Tai, Fuju;Chen, Feng;Hu, Xiuli. And the article was included in Journal of Experimental Botany in 2021.Safety of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol This article mentions the following:

In plants, 3′,5′-cyclic adenosine monophosphate (cAMP) is an important second messenger with varied functions; however, only a few adenylyl cyclases (ACs) that synthesize cAMP have been identified. Moreover, the biol. roles of ACs/cAMP in response to stress remain largely unclear. In this study, we used quant. proteomics techniques to identify a maize heat-induced putative disease-resistance RPP13-like protein 3 (ZmRPP13-LK3), which has three conserved catalytic AC centers. The AC activity of ZmRPP13-LK3 was confirmed by in vitro enzyme activity anal., in vivo RNAi experiments, and functional complementation in the E. coli cyaA mutant. ZmRPP13-LK3 is located in the mitochondria. The results of in vitro and in vivo experiments indicated that ZmRPP13-LK3 interacts with ZmABC2, a possible cAMP exporter. Under heat stress, the concentrations of ZmRPP13-LK3 and cAMP in the ABA-deficient mutant vp5 were significantly less than those in the wild-type, and treatment with ABA and an ABA inhibitor affected ZmRPP13-LK3 expression in the wild-type. Application of 8-Br-cAMP, a cAMP analog, increased heat-induced expression of heat-shock proteins in wild-type plants and alleviated heat-activated oxidative stress. Taken together, our results indicate that ZmRPP13-LK3, a new AC, can catalyze ATP for the production of cAMP and may be involved in ABA-regulated heat resistance. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Safety of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Safety of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

S-Adenosyl methionine cofactor modifications enhance the biocatalytic repertoire of small molecule C-alkylation was written by McKean, Iain J. W.;Sadler, Joanna C.;Cuetos, Anibal;Frese, Amina;Humphreys, Luke D.;Grogan, Gideon;Hoskisson, Paul A.;Burley, Glenn A.. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 4097-22-7 This article mentions the following:

A tandem enzymic strategy to enhance the scope of C-alkylation of small mols. via the in situ formation of S-adenosyl methionine (SAM) cofactor analogs is described. A solvent-exposed channel present in the SAM-forming enzyme SalL tolerates 5′-chloro-5′-deoxyadenosine (ClDA) analogs modified at the 2-position of the adenine nucleobase. Coupling SalL-catalyzed cofactor production with C-(m)ethyl transfer to coumarin substrates catalyzed by the methyltransferase (MTase) NovO forms C-(m)ethylated coumarins in superior yield and greater substrate scope relative to that obtained using cofactors lacking nucleobase modifications. Establishing the mol. determinants that influence C-alkylation provides the basis to develop a late-stage enzymic platform for the preparation of high value small mols. In the experiment, the researchers used many compounds, for example, ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7Reference of 4097-22-7).

((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Reference of 4097-22-7

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ammonium ions enhance proteolytic activation of adenylate cyclase and decrease its sensitivity to inhibition by “P”-site agonists was written by Yeung, Siu Mei Helena;Shoshani, Ilana;Stuebner, Dorothee;Johnson, Roger A.. And the article was included in Archives of Biochemistry and Biophysics in 1989.COA of Formula: C10H13N5O2 This article mentions the following:

A detergent-dispersed adenylate cyclase from rat brain was used to study the effects of ammonium salts and polyamines on the proteolytic activation of the enzyme by a sperm protease and on the sensitivity of adenylate cyclase to inhibition via its P-site. A purified preparation of a trypsinlike serine protease from bovine sperm was used to activate solubilized adenylate cyclase in the presence of guanosine 5′-O-(3-thiotriphosphate (GTPγS). The proteolytically activated form of adenylate cyclase was particularly sensitive to further activation by NH₄HCO₃. The activation by NH₄HCO₃ was due to the NH₄⁺ cation and was characterized by an increased V_max and by a decreased sensitivity of adenylate cyclase to inactivation by elevated concentrations of the sperm protease or by trypsin. NH₄Cl and (NH₄)₂SO₄ also caused biphasic effects on adenylate cyclase, that mimicked but were less effective than those caused by NH₄HCO₃. Consistent with observations of others, adenylate cyclase activity was enhanced by NH⁺ whether in the presence of reversible (Mn²⁺) or irreversible (GTPγS) activators. Mn²⁺– and GTPγS-stimulated activities were similarly optimally enhanced by 30 mM (NH₄)₂SO₄ and by 30-150 mM NH₄Cl or NH₄HCO₃. NH₄⁺ did not increase the activity of the purified catalytic unit. Moreover, the effect of NH₄⁺ was not accompanied by an increased rate of activation by GTPγS, suggesting that the activation of G_s (guanine nucleotide-dependent stimulatory component) may not be the primary cause of stimulation by ammonium salts. Several polyamines at millimolar concentrations blocked the stimulatory effect of NH₄⁺. This was observed when adenylate cyclase was activated by Mn²⁺, but not when it was activated by GTPγS or by the sperm protease plus GTPγS. The inhibitory effect of polyamines was not due to the formation of a complex with ATP. Both the increase in V_max of the Mn²⁺-stimulated enzyme by NH₄⁺ and the decrease in V_max caused by spermine were accompanied by an increase in the apparent K_m for MnATP. Spermine increased the IC₅₀ for inhibition of Mn²⁺-activated adenylate cyclase by 2′,5′-dideoxyadenosine (2′,5′-ddAdo) from 0.75 to 4.6 μM, consistent with the idea that increased sensitivity of P-site-mediated inhibition is associated with increased enzyme activity. In contrast, activation of Mn²⁺-stimulated adenylate cyclase by 30 mM (NH₄)₂SO₄ also reduced sensitivity to inhibition by 2′,5′-ddAdo (IC₅₀ 1.1 μM). This decreased sensitivity to inhibition by 2′,5′-ddAdo induced by NH₄⁺ was also observed on GTPS-activated or proteolytically activated adenylate cyclase. Thus, activation of adenylate cyclase by ammonium salts may be due to an effect on the conformation and(or) stability of the active form of the enzyme, leading to increased enzyme activity as well as to decreased proteolytic inactivation. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6COA of Formula: C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Role of regulator of G-protein signaling 2 (RGS2) in periodontal ligament cells under mechanical stress was written by Santos de Araujo, Rui M.;Oba, Yasuo;Moriyama, Keiji. And the article was included in Cell Biochemistry and Function in 2007.Related Products of 6698-26-6 This article mentions the following:

Mech. stress is thought to regulate the expression of genes in the periodontal ligament (PDL) cells. Using a microarray approach, we recently identified a regulator of G-protein signaling 2 (RGS2) as an up-regulated gene in the PDL cells under compressive force. The RGS protein family is known to turn off G-protein signaling. G-protein signaling involves the production of cAMP, which is thought to be one of the biol. mediators in response to mech. stress. Here, we investigated the role of RGS2 in the PDL cells under mech. stress. PDL cells derived from the ligament tissues of human premolar teeth were cultured in collagen gels and subjected to static compressive force. Compressive force application time-dependently enhanced RGS2 expression and intracellular cAMP levels. To examine the interrelationship between RGS2 and cAMP, the PDL cells were treated with 2′,5′-dideoxyadenosine (DDA), an inhibitor of adenyl cyclase, or antisense S-oligonucleotide (S-ODN) to RGS2 under compressive force. DDA dose-dependently inhibited RGS2 stimulated by compressive force. Blockage of RGS2 by antisense S-ODN elevated the cAMP levels compared with controls. These results indicate that cAMP stimulates RGS2 expression, which in turn leads to a decrease in the cAMP production by inactivating the G-protein signaling in the mech. stressed PDL cells. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Related Products of 6698-26-6).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Related Products of 6698-26-6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A correlation for 1,9-decadiene/water partition coefficients was written by Nitsche, Johannes M.;Kasting, Gerald B.. And the article was included in Journal of Pharmaceutical Sciences in 2013.Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol This article mentions the following:

An important series of papers by Xiang, Anderson, and coworkers has established the strong correlation between phospholipid bilayer membrane permeability and the 1,9-decadiene/water partition coefficient over a wide range of compounds, elevating the importance of K^decadiene/w as a predictor of mol. bioavailability. On the basis of a 58-point dataset developed by these authors, this research note develops an optimal correlation predicting log₁₀K^decadiene/w in terms of the octanol/water partition coefficient and four of the Abraham solvation parameters, namely A (hydrogen bond acidity), S (polarity/polarizability), E (excess molar refraction), and V (McGowan characteristic volume). The fitted dataset is described to within a root-mean-square error of 0.42, and the probable error in making a prediction for a compound not present therein is 0.49. It is shown that this correlation error for K^decadiene/w is the dominant source of uncertainty in applying a comprehensive new model of phospholipid bilayer membrane permeability developed in a companion paper (Nitsche and Kasting, submitted for publication), which superposes the effects of mol. size and lipid d. upon the decadiene lipophilicity scale. Thus, more exptl. studies to augment the limited existing database on K^decadiene/w are called for. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. In the experiment, the researchers used many compounds, for example, ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol).

((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Antibodies raised against the adenosine receptor agonist, 5′-N-ethylcarboxamidoadenosine (NECA) was written by Nakata, Hiroyasu. And the article was included in Journal of Biochemistry in 1993.Formula: C10H13N5O2 This article mentions the following:

Antisera against the nonselective adenosine receptor agonist 5′-N-ethylcarboxamidoadenosine (NECA) were raised by immunizing rabbits with NECA-coupled bovine serum albumin. The antisera which bind [³H]NECA with high affinity were purified by affinity chromatog. using NECA-coupled Sepharose as the affinity gel without significant changes in [³H]NECA-binding properties. The order of the affinity for various adenosine receptor ligands of the purified or unpurified antisera was 5′-N-cyclopropylcarboxamidoadenosine ≥ NECA>2′,5′-dideoxyadenosine>2-chloroadenosine > theophylline > IBMX > (R)-N⁶-phenylisopropyladenosine = N⁶-cyclohexyladenosine. The specificity was similar to that of the nonreceptor NECA-binding sites, which had been found in various tissues such as human placetas and mouse P815 mastocytoma cells, rather than to that of adenosine receptors. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Formula: C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Formula: C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response was written by Wann, A. K. T.;Knight, M. M.. And the article was included in Cellular and Molecular Life Sciences in 2012.Formula: C10H13N5O2 This article mentions the following:

Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centers for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate cilia function, governed in part by the activity of intraflagellar transport (IFT). In articular cartilage, primary cilia length is increased and hedgehog signaling activated in osteoarthritis (OA). Here, we examine primary cilia length with exposure to the quintessential inflammatory cytokine interleukin-1 (IL-1), which is up-regulated in OA. We then test the hypothesis that the cilium is involved in mediating the downstream inflammatory response. Primary chondrocytes treated with IL-1 exhibited a 50 % increase in cilia length after 3 h exposure. IL-1-induced cilia elongation was also observed in human fibroblasts. In chondrocytes, this elongation occurred via a protein kinase A (PKA)-dependent mechanism. G-protein coupled adenylate cyclase also regulated the length of chondrocyte primary cilia but not downstream of IL-1. Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2. However, in cells with a mutation in IFT88 whereby the cilia structure is lost, this response to IL-1 was significantly attenuated and, in the case of nitric oxide, completely abolished. Inhibition of IL-1-induced cilia elongation by PKA inhibition also attenuated the chemokine response. These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Formula: C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Formula: C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Signal transduction by HLA class II molecules in human T cells: induction of LFA-1-dependent and independent adhesion was written by Odum, Niels;Yoshizumi, Hideyuki;Okamoto, Yasuhiro;Kamikawaji, Nobuhiro;Kimura, Akinori;Nishimura, Yasuharu;Sasazuki, Takehiko. And the article was included in Human Immunology in 1992.Name: (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol This article mentions the following:

Crosslinking HLA-DR mols. by monoclonal antibodies (moAbs) induces protein tyrosine phosphorylation and results in a secondary elevation of free cytoplasmic calcium concentrations in activated human T cells. Binding of bacterial superantigens or moAbs to DR mols. on activated T cells was recently reported to induce homotypic aggregation through activation of protein kinase C (PKC) and mediated by CD11a/CD54 (LFA-1/CAM-1) adhesion mols. Here, the authors report that moAbs directed against framework DR, but neither DR1, 2- and DRw52- nor DQ- and DP-specific moABs induced homotypic aggregation of antigen- and alloantigen-activated T cells, antigen-specific CD4⁺ T-cell lines, a CD8⁺ T-cytotoxic cell line, and T-leukemia cells (HUT78). Protein tyrosine kinase (PTK) inhibitor herbimycin A partly blocked class-II-induced aggregation responses. In contrast, phorbol ester (PMA)-induced aggregation was essentially unaffected. A potent inhibitor of PKC, staurosporine, inhibited both moAb- and PMA-induced aggregation responses. The aggregation responses were completely inhibited by low temperatures, cytochalasins B and E, and partly inhibited by EDTA and CD18 moAbs, but unaffected by aphidicolin, mitomycin C, an adenylate cyclase inhibitor (2’5′-dideoxyadenosine), and moAbs against other adhesion mols. (CD2/CD58, CD28/B7, CD4, and CD44). In conclusion, HLA class-II-induced aggregation responses in activated T cells appear to involve PTK and PKC activation and to be mediated through CD11a-dependent and independent adhesion pathways. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Name: (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Name: (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One-pot synthesis of deoxyadenosine 3′-thiophosphates was written by Szczepanik, Maciej B.;Desaubry, Laurent;Johnson, Roger A.. And the article was included in Tetrahedron Letters in 1998.Electric Literature of C10H13N5O2 This article mentions the following:

A mild and efficient one-step method of thiophosphorylation was devised for acid-sensitive nucleosides. The procedure is based on thiophosphorylation of nucleoside magnesium alkoxide by 2-chloro-2-thio-1,3,2-dioxaphospholane. The utility and efficiency of this method combined with deprotection of the resulting cyclic triester was demonstrated by its application to the synthesis of both adenosine 3′- and 5′-thiophosphates. The procedure does not require protection of the exocyclic amino group and can be successfully used for the thiophosphorylation of nucleosides that are unusually sensitive to depurination. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Electric Literature of C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Electric Literature of C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem