Tag: 22929-52-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22929-52-8,Dihydrofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

Intermediate 163 Ethyl 1-(phenylmethyl)-3-[(tetrahydro-3-furanyl)amino]-1H-pyrazole-4-carboxylate. To a solution of ethyl 3-amino-1-(phenylmethyl)-1H-pyrazole-4-carboxylate (7.88 g, 32 mmol) and dihydro-3 (2H)-furanone (1.60 g, 18.6 mmol) in DCM (100 mL) was added sodium triacetoxyborohydride (7.88 g, 37 mmol) and acetic acid (3.2 mL). The mixture was stirred for 16 hours, partitioned between DCM and saturated sodium bicarbonate solution and applied through a hydrophobic frit. The organic fraction was evaporated, the residue purified using a 330 g ISCO Flash column, eluting with a gradient of ethyl acetate in cyclohexane (5- 60percent) to give the title compound. MS calcd for (C17H21N303+ H) + : 316 MS found (electrospray) : (M+H) += 316, 22929-52-8

The synthetic route of 22929-52-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/92863; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22929-52-8,Dihydrofuran-3(2H)-one,as a common compound, the synthetic route is as follows.

A. Methyl magnesium iodide (3.0M in Et2 O, 20 mL) was added to a solution of tetrahydrofuran-3-one (1.6 g, 18.6 mmol) in 15 mL of Et2 O at 0¡ã C. After stirring 4 h at 0¡ã C. the mixture was quenched with sat. aq. NH4 Cl solution and extracted with Et2 O. The combined extracts were dried over MgSO4 and concentrated under reduced pressure to give the crude material. Purification by chromatography (CH2 Cl2 to 1percent MeOH/CH2 Cl2 to 2percent MeOH/CH2 Cl2) gave 3-hydroxy-3-methyltetrahydrofuran (0.290 g). 1 H NMR consistent with structure.

As the paragraph descriping shows that 22929-52-8 is playing an increasingly important role.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; US5691372; (1997); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem