Tag: 17347-61-4

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,17347-61-4

To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy- 5a,5b,8,8,11a-pentamethyl-N-(1-(5-phenyl-1H-imidazol-2-yl)cyclopentyl)-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (step 2, 0.06 g, 0.09 mmol) and 2,2-dimethyl succinicanhydride (0.046 g, 0.36 mmol) in toluene (4 ml), was added DMAP (0.022 g, 0.18 mmol). The reaction mixture was heated at 90C for about 12 hours. After completion of the reaction (monitored by TLC), the reaction mixture was concentrated under reduced pressure, cooled to 0C, acidified to pH=6 with 1N HCl and extracted with DCM. The combined organic extracts were washed with water, brine, dried over Na2SO4 then the solvent was evaporated under reduced pressure and the resulting solid was recrystallized from ACN to afford the title compound (0.022 g, yield: 31%). 1H NMR (300 MHz, CDCl3): delta 7.65-7.62 (m, 2H), 7.36-7.29 (m, 4H), 4.59 (s, 1H), 4.51 (s, 1H), 4.46-4.38 (m, 1H), 2.93- 2.91 (m, 1H), 2.62-1.31 (m, 32H), 1.26 (s, 3H), 1.22 (s, 6H), 0.86-0.68 (m, 19H); ES Mass: 794.64 [M+H]+.

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.,17347-61-4

Example 25 : Preparation of 4-(((l S,3aS,5aR,5bR,7aR,9S, 11 aR, 1 IbR, 13aR, 13bR)-l – isopropyl-3a-((S)-2-(5-(4-metho xyphenyl)-lH-imidazol-2-yl)pyrro lidine- 1 -carbonyl)- 5a,5b,8,8,l la-pentamethylicosahydro-lH-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4- oxobutanoic acid: [0210] To a stirred solution of ((lS,3aS,5aR,5bR,7aR,9S,l laR,l lbR,13aR,13bR)-9- hydroxy- 1 -isopropyl-5 a,5b,8,8, 11 a-pentamethylicosahydro-3aH-cyclopenta[a]chrysen-3a- yl)((S)-2-(5-(4-methoxyphenyl)- lH-imidazol-2-yl)pyrrolidin- 1 -yl)methanone (Example 24- step 2, 0.2 g, 0.29 mmol) and 2,2-dimethyl succinicanhydride (0.14 g, 1.17 mmol) in toluene (6 mL) was added DMAP (0.07 g, 0.58 mmol). The reaction mixture was heated at 90¡ãC for 12 hours. After completion of the reaction (monitored by TLC), reaction mixture was concentrated under reduced pressure, cooled to 0¡ãC, acidified to pH = 6 with IN HC1 and extracted with DCM. The combined organic extracts were washed with water, brine, dried over Na2S04. Then the solvent was evaporated and to the resulting solid was recrystalised from ACN to give the title compound (0.09 g, Yield 26percent) as a white solid. 1H-NMR, CDC13, 300 MHz): delta 7.49- 7.47 (m, 2H), 7.12 (s, 1H), 6.89 (d, J = 8.7 Hz, 2H), 5.36- 5.34 (m, 1H), 4.54- 4.49 (m, 1H), 3.81 (s, 3H), 3.68- 3.56 (m, 2H), 2.94- 2.90 (m, 2H), 2.71- 1.12 (m, 36H), 0.99- 0.84 (m, 18H), 0.72 (d, J = 6.6 Hz, 3H); ESI MS: 812.5 (M+H).

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA REDDY, Adulla; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; VL SUBRAHMANYAM, Lanka; DAVID KRUPADANAM, Gazula, Levi; VENKATI, Mukkera; SUDHAKAR, Neela; SRINIVAS REDDY, Kallem; WO2014/105926; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,17347-61-4

Compound 6 (16 mg, 0.032 mmol), 2,2-dimethylsuccinic anhydride (41 mg, 0.32 mmol), DMAP (8 mg, 0.064 mmol) and pyridine (1.5 mL) were put into a 10 mL glass tube and sealed. The mixture was stirred at 120 C for about 12 h. The reaction mixture was then transferred into a 50 mL flask. Pyridine was removed under reduced pressure. 3N HCl (10 mL) was added, the mixture was extracted three times with EtOAc, and the organic layer washed with 3 N HCl for a second time. Then the organic layer was washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc as eluent) to provide target product 8 (11 mg). White solid, yield 54%. 1H NMR (CDCl3, 400 MHz,ppm) delta: 4.76 (d, 1H, J=12Hz, CH-OCO), in C3), 4.73 (s, 1H, C=CH,in C29), 4.60 (s, 1H, C=CH, in C29), 4.67, 4.51 (2m, 1H, CH-F, in C2), 3.66 (s, 3H, CO2CH3), 2.98 (m, 1H, in C19), 2.76-2.62 (2d, J=16 Hz, CO-CH2-C(CH3)2),1.67 (s, CH3, in C30), 1.32 (s, 6H, 2CH3, CO2H-C(CH3)2-CH2-),0.90, 0.88, 0.86, 0.83, 0.81 (5s, 5 x 3H, 5 x CH3, in C23, C24, C25, C26, C27). MS (ESI-) m/z: 639.45 (M+Na)+, 655.40 (M+K)+ for C37H57FO6.

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Li, Jizhen; Goto, Masuo; Yang, Xiaoming; Morris-Natschke, Susan L.; Huang, Li; Chen, Chin-Ho; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 68 – 71;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirring solution of compound 24-1 (55 mg, 0.10 mmol), DMAP (14.8 mg, 0.12 mmol) and 2,2-dimethylsuccinic anhydride (38.7 mg, 0.30 mmol) in dry pyridine (1.0 mL) is heated at 120¡ã C. for 4 hours.Another 0.30 mmol of 2,2-dimethylsuccinic anhydride is added and heating at 120¡ã C. is continued for 24 hours.The mixture is cooled down to room temperature and concentrated to dryness.The residue is diluted in ethyl acetate, washed twice with HCl 1N, water and brine, dried over sodium sulfate and concentrated to dryness.The residue is purified by flash column chromatography on silica gel (methanol/DCM 0percent to 10percent) to yield the title compound 19-2 as a white solid (48 mg, 71percent).1H NMR (400 MHz, CDCl3): delta [ppm] 7.71 (m, 2H), 7.50 (m, 1H), 7.42 (m, 2H), 6.11 (s, 1H), 4.48 (d*d, 1H), 3.17 (m, 1H), 2.90 (d, 1H), 2.83 (d, 1H), 2.66 (d, 1H), 2.55 (d, 1H), 2.41 (d, 1H), 2.36 (d, 1H), 1.95 (m, 3H), 1.76-1.16 (m, 26H), 1.13 (s, 3H), 0.97 (s, 3H), 0.87 (s, 3H), 0.83 (s, 3H), 0.79 (s, 3H).LC/MS: m/z=674.70 (M+H*).

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Moinet, Christophe; Halab, Liliane; Turcotte, Nathalie; Bubenik, Monica; Courchesne, Marc; Poisson, Carl; Pereira, Oswy Z.; Nguyen-Ba, Paul; Liu, Bingcan; Chauret, Nathalie; Cadilhac, Caroline; Kong, Laval Chan Chun; US2011/77227; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the above intermediates (8, 9, 10 or 11), 2,2-dimethylsuccinic anhydride (10 equiv) and DMAP (1 equiv) in anhydrous pyridine (20 mL/mmol) was refluxed overnight. The mixture was then concentrated under vacuum and the residue was chromatographed on silica gel to yield the derivatives 12, 13, 14 and 15.

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Coric, Pascale; Turcaud, Serge; Souquet, Florence; Briant, Laurence; Gay, Bernard; Royer, Jacques; Chazal, Nathalie; Bouaziz, Serge; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 453 – 465;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

A stirring solution of 17/?-benzoylamino-3/?-hydroxy-28-norlup-20(29)-ene (144 mg, 0.270 mmol), DMAP (40 mg, 0.324 mmol) and 2,2-dimethylsuccinic anhydride (208 mg, 1.62 mmol) in dry pyridine (3 mL) is heated overnight at 120¡ãC. Another 6 equivalents of anhydride is added and heating is continued for 7 hours. The mixture is concentrated to dryness and the residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash column chromatography on silica gel (ethyl acetate/hexanes 10percent to 70percent) followed by crystallization in ethyl acetate/hexanes (1 :3) to yield the title compound 13-7 as a white solid (30 mg, 16percent). 1H NMR (400 MHz, CDCl3): delta [ppm] 7.72 (m, 2H), 7.51 -7.41 (m, 3H), 5.81 (s, 1 H), 4.71 (d, 1 H), 4.62 (t, 1 H), 4.47 (d x d, 1 H), 2.82 (d x t, 1 H), 2.65 (m, 1 H), 2.64 (d, 1 H), 2.54 (d, 1 H), 2.44 (m, 1H), 1.95 (m, 1 H), 1.75-0.75 (m, 21H), 1.69 (s, 3H), 1.29 (s, 3H), 1.27 (s, 3H), 1.01 (s, 3H), 0.99 (s, 3H), 0.83 (s, 3H), 0.82 (s, 3H), 0.78 (s, 3H). LC/MS: m/z = 660.71 (M+H+). HPLC (Method A): tR = 34.04 min.

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/100532; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

General procedure: Compound 6 (16 mg, 0.032 mmol), 2,2-dimethylsuccinic anhydride (41 mg, 0.32 mmol), DMAP (8 mg, 0.064 mmol) and pyridine (1.5 mL) were put into a 10 mL glass tube and sealed. The mixture was stirred at 120 C for about 12 h. The reaction mixture was then transferred into a 50 mL flask. Pyridine was removed under reduced pressure. 3N HCl (10 mL) was added, the mixture was extracted three times with EtOAc, and the organic layer washed with 3 N HCl for a second time. Then the organic layer was washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc as eluent) to provide target product 8 (11 mg). White solid, yield 54%.

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Article; Li, Jizhen; Goto, Masuo; Yang, Xiaoming; Morris-Natschke, Susan L.; Huang, Li; Chen, Chin-Ho; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 68 – 71;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a solution of 3/?-hydroxy-21 -oxolup-18-en-28-oic acid N-benzylamide (110 mg, 0.196 mmol) in 3 mL of pyridine is added 2,2-dimethyl succinic anhydride (75.3 mg, 0.588 mmol) and DMAP (28.6 mg, 0.235 mmol). The reaction mixture is stirred overnight under reflux. Then 75.3 mg of 2,2-dimethyl succinic anhydride is added twice every 3 hours to complete the reaction. The solvent is evaporated in vacuo and the residue is taken up with ethyl acetate (50 mL) and HCl 1 N (10 mL). The organic layer is washed with water (2 x 30 mL), brine (30 mL) and dried over sodium sulfate. The crude material is purified by flash chromatography (Biotage) on silica gel (ethyl acetate / hexanes 0 to 50percent) to give the title compound 9-1 (118.6 mg, 88percent) as a colorless solid.1 H NMR (400 MHz, CDCl3): delta [ppm] 7.34 – 7.21 (m, 5H), 5.61 (d x d, 1 H), 4.59 (d x d, 1 H), 4.50 (d x d, 1 H), 4.20 (d x d, 1 H), 3.19 (sept., 1 H), 2.67 (d, 1 H), 2.65 – 2.54 (m, 2H), 2.56 (d, 1H), 2.45 (d, 1 H), 2.17 (1 H), 1.85 – 0.74 (m, 18H), 1.3 (s, 3H), 1.29 (s, 3H), 1.2 (d, 3H), 1.18 (d, 3H), 0.89 (br s, 6H), 0.86 (s, 3H), 0.82 (s, 3H), 0.8 (s, 3H). LC/MS: m/z = 688.68 (M+H+).

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIROCHEM PHARMA INC.; CHAURET, Nathalie; WO2009/82818; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-[2-(4-amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(pyridin- 4-yloxy) -phenyl]-urea (208 mg, 0.47 mmol) and 2,2-dimethylsuccinic anhydride (66 mg, 0.52 mmol, 1.1 eq) in 2 mL THF was stirred at room temperature overnight. HPLC analysis indicated that starting material was remaining. The reaction was then heated at 60¡ãC for 2 days, at which time HPLC analysis indicated the reaction was complete. The reaction mixture was cooled to room temperature, and the resulting suspension was diluted with Et20. The solid was isolated by filtration to afford the desired product (227 mg, 85percent). (at)H-NMR (DMSO-d6) 8 12.06 (s, 1 H), 10.06 (s, 1 H), 9.09 (s, 1 H), 8.40 (d, J = 6.0 Hz, 2H), 8.31 (s, 1 H), 7.69 (d, J = 9.0 Hz, 2H), 7.47 (d, J = 9.0 Hz, 2H), 7.39 (d, J = 9.0 Hz, 2H), 7.07 (d, J = 9.0 Hz, 2H), 6.85 (dd, J = 1.5 4.7 Hz, 2H), 6.33 (s, 1 H), 2.59 (s, 2H), 1.26 (s, 9H), 1.21 (s, 6H) ; MS LC-MS [M+H] (at) = 571.3, RT = 2.49 min.

17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; BAYER PHARMACUETICALS CORPORATION; WO2005/110994; (2005); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

General procedure: Compound 5 (16 mg, 0.032 mmol), 2,2-dimethyl succinic anhydride(41 mg, 0.32 mmol), DMAP (8 mg, 0.064 mmol), and pyridine (1.5 mL)were placed in a 10 mL glass tube and sealed. The mixture was stirred at120 C for about 12 h. The reaction mixture was then transferred into a50 mL flask. Pyridine was removed under reduced pressure. HCl (3 N,10 mL) was added, the mixture was extracted three times with EtOAc,and the organic layer washed with 3 N HCl for a second time. Then theorganic layer was washed with brine, dried over anhydrous Na2SO4,and concentrated in vacuo. The residue was purified by silica gelcolumn chromatography (hexane/EtOAc as eluent) to provide targetproduct 7 (11 mg). White solid, yield: 54%. 1H NMR (CDCl3, 400 MHz,ppm) delta: 4.76 (d, 1H, J=12 Hz, CH-OCO), in C3), 4.73 (s, 1H, C=CH,in C29), 4.60 (s, 1H, C=CH, in C29), 4.51-4.67 (m, 1H, CH-F, in C2),3.66 (s, 3H, CO2CH3), 2.92-2.98 (m, 1H, in C19), 2.62-2.76 (2d,J=16 Hz, CO-CH2-C(CH3)2), 2.17-2.23 (m, 3H, in C18 and C22),1.87-1.90 (m, 2H, in C1), 1.67 (s, 3H, CH3, in C30), 1.32 (s, 6H, 2CH3,CO2H-C(CH3)2-CH2-), 0.90 (s, 3H, CH3), 0.88 (s, 3H, CH3), 0.86 (s, 3H,CH3), 0.83 (s, 3H, CH3), 0.81 (s, 3H, CH3). 13C NMR (150 MHz, CDCl3) delta 176.50 (s), 176.23 (s), 170.83 (s), 150.27 (s), 109.60 (s), 89.47 (d,J=173.2 Hz), 81.47 (d, J=15.1 Hz), 56.38 (s), 54.89 (s), 51.13 (s),50.28 (s), 49.28 (s), 46.85 (s), 44.40 (d, J=17.8 Hz), 42.32 (s), 40.60(s), 39.42 (d, J=6.9 Hz), 38.55 (d, J=10.2 Hz), 38.01 (s), 36.80 (s),33.89 (s), 31.98 (s), 30.42 (s), 29.47 (s), 28.13 (s), 25.33 (s), 25.26 (s),25.16 (s), 24.92 (s), 20.93 (s), 19.17 (s), 18.02 (s), 17.39 (s), 17.14 (s),15.81 (s), 14.51 (s). 19F NMR (CDCl3, 376 MHz, ppm) delta: -190.57. ESIHRMS(m/z): calcd for C37H57FO6 [M+H]+: 617.4217, found617.4169.

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Article; Li, Jizhen; Chang, Ling-Chu; Hsieh, Kan-Yen; Hsu, Pei-Ling; Capuzzi, Stephen J.; Zhang, Ying-Chao; Li, Kang-Po; Morris-Natschke, Susan L.; Goto, Masuo; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2871 – 2882;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem