Tag: 16874-33-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.,16874-33-2

Example-3: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro- 2-furan carboxamide (Alfuzosin)To a mixture of terahydrofuroic-2-acid (99.7 gm) and dichloromethane (600ml) at 0 to 50C, triethylamine (86.8 gm) was added. To the resulting reaction mixture, ethyl chloroformate (93.2 gm) was added at low temperature. The reaction mixture was further stirred for one hour and a slurry of N]-(4-Amino-6,7-dimethoxyquinazol-2-yl)-Ni-methylpropylenediamine (100 gm) in dichloromethane (400 ml) was added. The resultant mixture was stirred for about one hour for the completion of the reaction and sodium hydroxide solution (500 ml, IN) was added. The layers were separated and the organic layer was washed with sodium hydroxide solution and concentrated under vacuum. The residue thus obtained was stirred with methanol (200 ml) for three hours to get slurry, which was filtered to get alfuzosin base in solid form. The product thus obtained was re-crystallized from methanol to get pure, isolated, solid alfuzosin base. Yield: 75 gm Purity: 99.8percent

The synthetic route of 16874-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WOCKHARDT LTD.; NATHANI, Pankaj Kumar; NARODE, Sunil Dnyaneshwar; SIDDIQUI, Mohammad Jaweed Mukarram; WO2007/69050; (2007); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)phenyl](400 mg, 1.30 mmol) in dichloromethane (10ml) of 1- (3-dimethylaminopropyl propyl)-3-ethylcarbodiimide hydrochloride (270mg, 1.43mmol), tetrahydrofuran-2-carboxylic acid (170mg, 1.43mmol), triethylamine (200 mg, 1.95 mmol) was added at 0¡ã C., 2 hours at room temperature and the mixture was stirred. The reaction mixture was poured into a saturated aqueous solution of sodium bicarbonate, and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography and purified by (elution solvent ethyl acetate / n-hexane = 1/1) to give the title compound as a brown oil (the yield 340 mg, 64percent yield).

16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; HOKKO CHEMICAL INDUSTRY COMPANY LIMITED; SUZUKI, JUN; TAJINO, HIDEHIRO; OKAMURA, DAIGO; GUSHIKAWA, TORU; ONOUE, SHINJI; HIRAMATSU, MOTOHIRO; (186 pag.)JP2015/36377; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Preparation c-90 Ethyl tetrahydrofuran-2-carboxylate To a solution of tetrahydrofuran-2-carboxylic acid (20 g, 172.2356 mmol) in anhydrous ethanol (100 mL) was added concentrated sulfuric acid (0.46 mL). The resulting mixture was stirred at reflux for 16 hours and then allowed to cool to ambient temperature. To this was added water (100 mL) and extracted with diethyl ether (3*100 mL). The combined organic extracts were washed with saturated aqueous sodium bicarbonate (2*50 mL), saturated aqueous sodium chloride (100 mL), dried (anhydrous magnesium sulfate), filtered and concentrated in vacuo to afford the pure product as a colorless liquid (22.5964 g, 91%). LRMS (m/z): 145 (M+H)+. 1H NMR (CDCl3, 300 MHz) delta 4.38 (1H, dd, J=4.9, 8.1 Hz), 4.14 (2H, q, J=7.2 Hz), 3.99-3.92 (1H, m), 3.88-3.81 (1H, m), 2.24-2.12 (1H, m), 2.00-1.79 (3H, m), 1.22 (3H, t, J=7.2 Hz).

The synthetic route of 16874-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/187266; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of 2-tetrahydrofuroic acid (288 mL, 3 mmol) in chloroform (5 mL) was added thionyl chloride (660 muL, 9 mmol) and the reaction heated to reflux for 1 hour. The reaction was cooled and concentrated under reduced pressure to provide tetrahydro-furan-2-carbonyl chloride (405 mg, 3 mmol).

16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; WYETH; WO2008/73929; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem