With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10374-51-3,5-(Hydroxymethyl)dihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.,10374-51-3
A solution of 10 (4.22 g, 36.35 mmol) in DMF (45 mL) was cooled to 0 C (ice bath). Imidazole (3.70 g, 54.35 mmol) was added, followed by TBDPSCl (11.3 mL, 43.46 mmol). After stirring at 0 C for 15 min the ice bath was removed and the mixture was stirred at room temperature for 16 h. After this time, the reaction mixture was partially concentrated at reduced pressure and the resulting residue was partitioned between EtOAc and water. The organic extract was washed with saturated NH4Cl, 5% LiCl, and brine, dried over Na2SO4, filtered and concentrated.The residue was purified by column chromatography (silica, gradient 0-40% EtOAc, hexanes) to provide 11 (10.51 g, 82%): 1H-NMR (500 MHz, CDCl3) delta 7.67-7.64 (m 4H), 7.46-7.38 (m, 6H), 4.60 (ddt, J = 8.1, 5.1, 3.2 Hz, 1H), 3.88 (dd,J = 11.4, 3.4 Hz, 1H), 3.69 (dd, J = 11.4, 3.4 Hz, 1H), 2.67 (ddd, J = 17.6, 10.3, 7.2 Hz, 1H), 2.51 (ddd, J = 17.8, 10.1,6.5 Hz, 1H), 2.33-2.18 (m, 2H), 1.06 (s, 9H). 13C-NMR (125 MHz, CDCl3) delta 177.4, 135.7, 135.5, 133.0, 132.6, 129.9,127.9, 80.0, 65.5, 28.6, 26.8, 23.7, 19.2. Mass spectral data could not be obtained.
As the paragraph descriping shows that 10374-51-3 is playing an increasingly important role.
Reference£º
Article; Pasetto, Paolo; Naginskaya, Jennifer; Tetrahedron Letters; vol. 59; 29; (2018); p. 2797 – 2799;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem