Heterocyclic Building Blocks-Tetrahydrofuran

Phytohormone profiles in non-transformed and AtCKX transgenic centaury (Centaurium erythraea Rafn) shoots and roots in response to salinity stress in vitro was written by Trifunovic-Momcilov, Milana;Motyka, Vaclav;Dobrev, Petre I.;Markovic, Marija;Milosevic, Snezana;Jevremovic, Sladjana;Dragicevic, Ivana C.;Subotic, Angelina. And the article was included in Scientific Reports in 2021.Safety of N6-(3-Methyl-2-butenyl)adenosine This article mentions the following:

Plant hormones regulate numerous developmental and physiol. processes. Abiotic stresses considerably affect production and distribution of phytohormones as the stress signal triggers. The homeostasis of plant hormones is controlled by their de novo synthesis and catabolism. The aim of this work was to analyze the contents of total and individual groups of endogenous cytokinins (CKs) as well as indole-3-acetic acid (IAA) in AtCKX overexpressing centaury plants grown in vitro on graded NaCl concentrations (0, 50, 100, 150, 200 mM). The levels of endogenous stress hormones including abscisic acid (ABA), salicylic acid (SA) and jasmonic acid (JA) were also detected. The elevated contents of total CKs were found in all analyzed centaury shoots. Furthermore, increased amounts of all five CK groups, as well as enhanced total CKs were revealed on graded NaCl concentrations in non-transformed and AtCKX roots. All analyzed AtCKX centaury lines exhibited decreased amounts of endogenous IAA in shoots and roots. Consequently, the IAA/bioactive CK forms ratios showed a significant variation in the shoots and roots of all AtCKX lines. In shoots and roots of both non-transformed and AtCKX transgenic centaury plants, salinity was associated with an increase of ABA and JA and a decrease of SA content. In the experiment, the researchers used many compounds, for example, N6-(3-Methyl-2-butenyl)adenosine (cas: 7724-76-7Safety of N6-(3-Methyl-2-butenyl)adenosine).

N6-(3-Methyl-2-butenyl)adenosine (cas: 7724-76-7) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Safety of N6-(3-Methyl-2-butenyl)adenosine

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Direct photo-patternable, low-temperature processable polyimide gate insulator for pentacene thin-film transistors was written by Jang, Kwang-Suk;Suk, Hye Jung;Kim, Won Soo;Ahn, Taek;Ka, Jae-Won;Kim, Jinsoo;Yi, Mi Hye. And the article was included in Organic Electronics in 2012.Category: tetrahydrofurans This article mentions the following:

We have developed photo-sensitive, low-temperature processable, soluble polyimide (PSPI) gate insulator with excellent resistance to the photo-patterning process. The PSPI was synthesized through one-step condensation polymerization of monomers 5-(2,5-dioxytetrahydrofuryl)-3-methyl-3-cyclohexene-1,2-dicarboxylic anhydride (DOCDA) and 3,5-diaminobenzyl cinnamate (DABC). PSPI thin film, fabricated at 160°C, has a dielec. constant of 3.3 at 10 kHz, and leakage c.d. of <1.7 × 10^-10 A/cm², while biased from 0 to 100 V. PSPI could be easily patterned by selective UV-light exposure and dipping into γ-butyrolactone. To investigate the potential of the polyimide as the photo-patternable gate insulator, we fabricated pentacene OTFTs and confirmed the PSPI’s resistance to the photo-patterning process. The photo-patternable polyimide shows promise as gate dielecs. for OTFTs. In the experiment, the researchers used many compounds, for example, 6-(2,5-Dioxotetrahydrofuran-3-yl)-4-methyl-7,7a-dihydroisobenzofuran-1,3(3aH,6H)-dione (cas: 73003-90-4Category: tetrahydrofurans).

6-(2,5-Dioxotetrahydrofuran-3-yl)-4-methyl-7,7a-dihydroisobenzofuran-1,3(3aH,6H)-dione (cas: 73003-90-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A validated potentiometric method for determination of alfuzosin hydrochloride in pharmaceutical and biological fluid samples was written by El Badry Mohamed, Marwa;Frag, Eman Y.;Gamal Eldin, Yasmin M.. And the article was included in Journal of the Iranian Chemical Society in 2020.HPLC of Formula: 81403-68-1 This article mentions the following:

Recently, graphene nanosheet has attracted the most attention for the potential applications in various electrochem. sensing fields to biomedical diagnosis and therapy due to its large theor. sp. surface area, unique phys. and elec. properties. In this paper, a newly sensitive and selective modified carbon paste electrodes (MCPEs) were developed for the determination of alfuzosin hydrochloride (ALF.HCl) in pharmaceutical preparation and biol. fluid samples. The paste of these sensors was prepared by mixing alfuzosin phosphomolybdate (ALF-PMA) and alfuzosin tetraphenylborate (ALF-TPB) ion pairs as recognition reagents with different supporting matrixes including graphite powder alone or different ratios of graphite to graphene powders and plasticizer of a relatively high dielec. constant The sensor prepared based on graphite alone as a supporting matrix gave Nernstian slope values of 56.7 ± 0.75 and 51.1 ± 1.11 mV decade-1 for electrode modified with ALF-PMA and ALF-TPB ion pairs, resp., in the concentration range from 1.0 x 10-5 to 1.0 x 10-2 mol L-1 at 25 °C, and the response of the electrode was found to be independent on pH in the range of 2.0-5.0. The Nernstian slope for ALF-TPB modified carbon paste electrode was improved to be 55.8 ± 1.07 mV decade-1 upon mixing graphene with graphite in the paste and showed pH independence in the range of 2.0-6.0. The proposed sensors were successfully applied for the determination of ALF. HCl in pure, biol. fluid samples and pharmaceutical preparation using the direct potentiometric and standard addition methods. Finally, the results obtained using the proposed sensors were compared with those from the official method. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1HPLC of Formula: 81403-68-1).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.HPLC of Formula: 81403-68-1

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthesis and antibacterial activity evaluation of N(7)-position-modified balofloxacins was written by Hong, Ge;Li, Weitian;Mao, Lina;Wang, Jiawen;Liu, Tianjun. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Recommanded Product: Tetrahydrofuran-2-carboxylic acid This article mentions the following:

A series of small-mol. fluoroquinolones, I [R = COMe, cyclopropylcarbonyl, pyridin-3-ylcarbonyl, etc.], II [R² = COMe, 1,2,4-triazol-y-ylacetyl], and III, were synthesized, characterized by HRMS and NMR spectroscopy, and screened for their antibacterial activity against MRSA, P. aeruginosa, and E. coli as model G⁺/G^– pathogens. Compounds I [R = Me, Et, n-Pr] were more potent than the reference drug balofloxacin against MRSA and P. aeruginosa (MIC values of 0.0195 and 0.039μg/mL for I [R = Me] (IV), 0.039 and 0.078μg/mL for each of I [R = Et, n-Pr], resp.). Anal. of the time-dependent antibacterial effect of compound IV toward MRSA showed that in the early logarithmic growth phase, bactericidal effects occurred, while in the late logarithmic growth phase, bacterial inhibition occurred because of concentration effects and possibly the development of drug resistance. Compound IV exhibited low toxicity toward normal mammalian cell lines 3T3 and L-02 and tumor cell lines A549, H520, BEL-7402 and MCF-7. The compound was not hemolytic. Atomic force microscopy (AFM) revealed that IV could effectively destroy the membrane and wall of MRSA cells, resulting in the outflow of the cellular contents. Docking studies indicated the good binding profile of these compounds toward DNA gyrase and topoisomerase IV. ADMET’s prediction showed that most of the synthesized compounds followed Lipinski’s “rule of five” and possessed good drug-like properties. Our data suggested that compound IV exhibited potent anti-MRSA activity and is worthy of further investigation. In the experiment, the researchers used many compounds, for example, Tetrahydrofuran-2-carboxylic acid (cas: 16874-33-2Recommanded Product: Tetrahydrofuran-2-carboxylic acid).

Tetrahydrofuran-2-carboxylic acid (cas: 16874-33-2) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Recommanded Product: Tetrahydrofuran-2-carboxylic acid

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition was written by Li, Ning;Zong, Min-Hua;Ma, Ding. And the article was included in Journal of Biotechnology in 2009.SDS of cas: 957-75-5 This article mentions the following:

Substrate recognition of Thermomyces lanuginosus lipase in the acylation of nucleosides was revealed through rational substrate engineering for the first time. T. lanuginosus lipase displayed higher catalytic activities and excellent 5′-regioselectivities (94->99%) in the acylation of ribonucleosides 1f-1j as compared to those in the acylation of 2′-deoxynucleosides 1a-1e. The higher reaction rates and excellent 5′-regioselectivities might derive from a favorable hydrogen bonding between the 2′-hydroxyl group of 1f-1j and phenolic hydroxyl group of Tyr-21 present in the hydrophilic region of the lipase. In the experiment, the researchers used many compounds, for example, 5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (cas: 957-75-5SDS of cas: 957-75-5).

5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (cas: 957-75-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.SDS of cas: 957-75-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The synthesis of partially-protected 2′-deoxyribonucleotide dimers by the selective phosphorylation of stannylated nucleosides was written by Kawana, Masajiro;Kuzuhara, Hiroyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1984.SDS of cas: 4836-13-9 This article mentions the following:

In the new method for the synthesis of the title compounds, the activation of the hydroxyl moieties of 5′-O-dimethoxytrityl and 3′,5′-unprotected 2′-deoxyribonucleosides, which were appropriately protected on their base residues, was done with (Bu₃Sn)₂O in sep. flasks. The resulting stannylated nucleosides were coupled with 2-chlorophenyl phosphorodichloridate to form the dimers with 3’→4′ internucleotide linkages in yields of more than 71%, along with the corresponding 3′ → 3′ isomers in yields of less than 10%. The method of Cashion et al. was also evaluated, in which up-to-date protecting groups were employed. In the experiment, the researchers used many compounds, for example, N-(1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (cas: 4836-13-9SDS of cas: 4836-13-9).

N-(1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (cas: 4836-13-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.SDS of cas: 4836-13-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion in rats. was written by Shen, Fengyan;Meng, Yong;He, Yuhai;Huang, Bowan;Huang, Jinxin;Wang, Lu. And the article was included in Molecular medicine reports in 2023.Category: tetrahydrofurans This article mentions the following:

Stroke is one of the leading causes of death from diseases. When the blood supply to the brain tissue is interrupted, neuronal core death occurs due to the lack of glucose and oxygen in min. Blood pressure lowering after ischemic stroke was proven to be an effective strategy to achieve neurovascular protection and reduce the risk of recurrent stroke. Astragaloside IV is a pure small molecular compound isolated from Radix Astragali, and it is well documented that astragaloside IV has neuroprotective effect on cerebral ischemia reperfusion (CIR) injury through many mechanisms, including antioxidant, anti‑inflammatory and anti‑apoptotic. The present study adopted mean arterial pressure (MAP) monitoring, neurological scoring, 2,3,5‑triphenyltetrazolium chloride staining, enzyme‑linked immuno‑sorbent assay, western blotting and other experimental methods to investigate the effect of astragaloside IV on systemic blood pressure during CIR in a middle cerebral artery occlusion animal model. It was demonstrated that astragaloside IV pretreatment significantly alleviated CIR injury as previously reported. In addition, the elevation of MAP during CIR was significantly inhibited by astragaloside IV administration. Moreover, it was revealed that the expression of Na+‑K+‑2Cl‑ cotransporter isoform 1 in the hypothalamus was inhibited and the subsequent synthesis of vasopressin was reduced by astragaloside IV pretreatment in the CIR animal model. In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4Category: tetrahydrofurans).

(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alfuzosin: an α₁-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia was written by Elhilali, Mostafa M.. And the article was included in Expert Opinion on Pharmacotherapy in 2006.Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:

α₁-Receptor blockers have become first-line therapy for the medical management of lower urinary tract symptoms associated with benign prostatic hyperplasia. However, adverse effects such as cardiovascular intolerance can limit their use. This article focuses on alfuzosin, a clin. uroselective, α₁-adrenergic antagonist that is available as a novel once-daily formulation that does not require dose titration Alfuzosin is less vasoactive than other non-subtype selective α₁-receptor blockers. In addition to effects on lower urinary tract symptoms, it is also used as an adjunct to urethral catheterisation in patients with acute urinary retention related to benign prostatic hyperplasia, and can improve sexual function and health-related quality of life in benign prostatic hyperplasia sufferers. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Recommanded Product: N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Performance and efficiency of removal of pharmaceutical compounds from hospital wastewater by lab-scale biological treatment system was written by Azuma, Takashi;Otomo, Kana;Kunitou, Mari;Shimizu, Mai;Hosomaru, Kaori;Mikata, Shiori;Mino, Yoshiki;Hayashi, Tetsuya. And the article was included in Environmental Science and Pollution Research in 2018.Related Products of 3094-09-5 This article mentions the following:

The fate of pharmaceuticals after discharged from hospital into wastewater was clarified exptl. by using a new lab-scale conventional activated sludge (CAS) treatment reactor. The 43 target compounds belong to nine therapeutic classes (antivirals, antibacterials, anticancer drugs, psychotropics, antihypertensives, analgesic-antipyretics, contrast media, herbal medicines, and phytoestrogens) were selected with inclusion of 16 newly estimated compounds The efficiency of the present reactor was estimated by comparing the reaction rate constant of the solid-water partition coefficients (log K_d) between liquid and solid samples and half-life during 48-h experiment obtained by using hospital effluents with those obtained by using STP wastewater. The results that no significant difference in removal efficiency was observed between both water samples (P > 0.05) indicate high reliability of the present lab-scale reactor. The actual rates of removal when hospital effluent was applied varied widely (mean, 59 ± 40%) independent of type of the pharmaceuticals. More than 90% of 17 compounds were removed after 8 h of treatment. However, the values for psychotropics (mean, 19 ± 26%) and contrast media (mean, 24 ± 17%) were generally low, indicating high stability. The log K_d values ranged from 1.3 to 4.8. Notably, clarithromycin, acridine, and glycitein could be removed in both liquid and solid phases. The dominant removal mechanisms were found to be different for individual pharmaceutical. These results suggest the effectiveness of introduction of the lab-scale biol. treatment system for development of a new solution for discharge of pharmaceuticals from hospital. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5Related Products of 3094-09-5).

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Related Products of 3094-09-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Enhanced efficacy of postoperative adjuvant chemotherapy in advanced gastric cancer: results from a phase 3 randomized trial (AMC0101) was written by Kang, Yoon-Koo;Yook, Jeong Hwan;Chang, Heung-Moon;Ryu, Min-Hee;Yoo, Changhoon;Zang, Dae Young;Lee, Jae-Lyun;Kim, Tae Won;Yang, Dae Hyun;Jang, Se Jin;Park, Young Soo;Lee, Young Jack;Jung, Hwoon-Yong;Kim, Jin-Ho;Kim, Byung Sik. And the article was included in Cancer Chemotherapy and Pharmacology in 2014.Safety of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione This article mentions the following:

Purpose: To improve the efficacy of adjuvant chemotherapy with mitomycin-C and fluoropyrimidine (Mf) in gastric cancer, we designed a new regimen (iceMFP) and investigated in a phase III study. Methods: We randomly assigned 640 patients with resectable and macroscopically recognizable serosa-invading gastric cancer to Mf or iceMFP group during operation. The Mf consisted of i.v. mitomycin-C (20 mg/m²) at 3-6 wk after surgery and oral doxifluridine (460-600 mg/m²/day) starting 4 wk after the administration of mitomycin-C and continuing for 3 mo. The iceMFP consisted of intraoperative i.p. cisplatin (100 mg), i.v. mitomycin-C (15 mg/m²) on postoperative day 1, followed by oral doxifluridine for 12 mo, and six monthly i.v. cisplatin (60 mg/m²). The primary endpoint was 3-yr recurrence-free survival (RFS). Results: A total of 521 patients (258 in Mf, 263 in iceMFP) were eligible for anal. after excluding patients with stage I disease, distant metastasis, or R1 resection. With a median follow-up of 3.5 years, the iceMFP group had a higher RFS (hazard ratio [HR] 0.70; 95 % confidence interval [CI] 0.54-0.90; p = 0.006; 3-yr RFS 60 % vs. 50 %) and overall survival (HR 0.71; 95 % CI 0.53-0.95; p = 0.02; 3-yr overall survival, 71 vs. 60 %) compared with the Mf group. This was confirmed at extension anal. after a median 6.6 years of follow-up. Both regimens were well tolerated with no differences in surgical complications. Conclusion: The efficacy of adjuvant Mf was significantly improved by the addnl. therapeutic strategies of iceMFP. Considering neg. results of AMC0201, these suggest that early initiation of chemotherapy and/or i.p. cisplatin played a distinct role in the improved efficacy. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5Safety of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione).

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem