Category: 915095-89-5

Related Products of 915095-89-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.915095-89-5, Name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, molecular formula is C17H16BrClO2. In a Patent，once mentioned of 915095-89-5

A process for synthesizing according to handkerchief row only (by machine translation)

The invention relates to a process for synthesizing according to handkerchief row only, to 4 – fluoro toluene as the starting material, by free-radical bromination reaction, crafts alkylation reaction, deprotection, diazo-chlorination reaction, alkylation reaction get intermediate (S)- 3 – (4 – (5 – bromo – 2 – benzylic) phenoxy) tetrahydrofuran, then with 2, 3, 4, 6 – trimethyl silicon-based – D – four – O – glucolactone by condensation, ether, obtained according to handkerchief row only escapes the methoxy hypoglycemic. The advantage of this invention is characterized in that: the invention according to handkerchief row only of the synthesis process, compared with the prior synthetic method, to 4 – fluoro toluene as the starting material, the price of raw materials are cheap and easily obtained, the process is easy to realize industrialization, short synthetic route, and easy to operate; and the preparation process in the process, each temperature condition is easy to control, the reaction conversion rate is relatively high, can make the total yield is up to 70% or more; in addition, the synthetic process of the present invention, the product is not easy to isomerization, less impurities, can improve the purity of the product, can make the purity of 99% or more. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 915095-89-5

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 915095-89-5, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 915095-89-5, name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran. In an article，Which mentioned a new discovery about 915095-89-5

According to handkerchief row net intermediate preparation method (by machine translation)

The invention provides a method for preparing according to handkerchief row net intermediate, comprises the following steps: 1) to 4 – fluoro toluene with (R)- 3 – hydroxy tetrahydrofuran as raw materials, polar solvent as a reaction solvent, inorganic alkali as a catalyst, the reaction is carried out to prepare the (S)- 3 – to a phenol-based tetrahydrofuran; 2) to N – chloro succinimide with step 1) the obtained product as raw materials, non-polar solvent is used as the reaction solvent, dibenzoyl peroxide as an initiator such as azobisisobutyronitrile or partner, reaction of (S)- 3 – to the chloromethane phenol-based tetrahydrofuran; 3) the 4 – bromophenyl, step 2) of the product is dissolved in ethyl acetate, and add catalyst Lewis acid reaction of (S)- 3 – (4 – (5 – bromo – 2 – aminobenzyl) phenoxy) tetrahydrofuran; 4) step 3) products of the diazotization reaction, then with the cuprous chloride reaction synthesis (S)- 3 – (4 – (5 – bromo – 2 – benzylic) phenoxy) tetrahydrofuran. The method is low in cost, final product has high purity, and the synthetic route is short. (by machine translation)

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 915095-89-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.915095-89-5, Name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, molecular formula is C17H16BrClO2. In a Patent£¬once mentioned of 915095-89-5

COMPLEX OF SGLT2 INHIBITOR AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a crystalline Form A of complex of Empagliflozin with L-Proline and process for preparation thereof. The present invention further relates to a method of preparing pure crystalline Empagliflozin via formation of the said complex.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 915095-89-5

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 915095-89-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.915095-89-5, Name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, molecular formula is C17H16BrClO2. In a article£¬once mentioned of 915095-89-5

A method for preparing graciousness Geleg only (by machine translation)

The invention discloses a method for preparing graciousness Geleg only, comprises the following steps: 1) the compound 5 after through Grignard exchange reaction with the glucose lactone derivative 6 reaction to obtain compound 7; Wherein X is bromine or iodine, LG is chlorine, bromine, armor sulphur acyloxy or paratoluene sulfonyloxy, PG is acetyl, bi acyl or benzoyl; 2) under the action of alkali compound 7 of deprotection of the final product is obtained positions near to the graciousness Geleg 8 compound; The preparation routes the operation is simple, shortening reaction step, not only higher yield, purity of the obtained products is also high, and suitable for production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 915095-89-5

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 915095-89-5, Name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, molecular formula is C17H16BrClO2

A 6 – halogenated glucose carbon glucoside and its preparation method and application (by machine translation)

The invention discloses a 6 – halogenated glucose carbon glucoside and its preparation method and application, the 6 – halo glucose carbon glucoside structure shown in formula I, the intermediates can be used for the cheap and easy synthesis raw material with high efficiency, at the same time, adopting the raw material for the synthesis of graciousness geleg only, reaches geleg only and its analogue, the reaction yield is high, the obtained product high purity, with comparatively high industrial application prospect. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 915095-89-5, in my other articles.

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C17H16BrClO2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 915095-89-5

Synthetic method of (by machine translation)

The method disclosed by the invention is mild in reaction condition, high. in overall yield, less in side reaction, and convenient to operate, and is, beneficial, to industrial production and cost control . (by machine translation)

If you are interested in 915095-89-5, you can contact me at any time and look forward to more communication. HPLC of Formula: C17H16BrClO2

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 915095-89-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.915095-89-5, Name is (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran, molecular formula is C17H16BrClO2. In a article£¬once mentioned of 915095-89-5

Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein

The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 915095-89-5

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

915095-89-5,915095-89-5, (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Take (S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy) tetrahydrofuran 183kg,400kg anhydrous THF/toluene (1:4) was added to the nitrogen-dried 3000 litre reactor.The liquid nitrogen was cooled to -78, and hexane solution of 1. 6 mol¡¤L-1 n-butyllithium was slowly added dropwise.Stirring was continued at this temperature for 1 h; 600 kg of a 2,3,4,6-tetra-O-trimethylsilyl-D-glucono-lactone (256 kg) in toluene solution cooled to -78C was slowly added dropwise to the above 600 kg. In the reaction solution,-78 reaction for 3 h, after the basic reaction of TLC detection is completed,At this temperature is added 500kg of methanesulfonic acid in methanol solution (methanesulfonic acid 225kg + methanol 275kg);The reaction was stirred at 0 C 4h, and then warmed to 40 C stirred reaction 6h;5 mol?L-1 sodium hydroxide aqueous solution was added to the reaction solution, and the pH was adjusted to 7-8; stirring for 30 min,Extract with ethyl acetate (300kg¡Á2)The organic phase is washed with saturated aqueous sodium chloride solution until neutral, then dried over anhydrous sodium sulfate and filtered.The filtrate was concentrated to dryness to give 208 kg of a light yellow viscous oil with a yield of 87%.

915095-89-5 (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 15941217, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Engineering Polytechnic College; Feng Chengliang; Yan Bin; (12 pag.)CN107652278; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

915095-89-5,915095-89-5, (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2.90 g (S)-3-[4-(5-bromo-2-chloro-benzyl)-phenoxy]-tetrahydrofuran in 4 mL of THF at 0 to 20 C. (or alternatively at 20 C.), is slowly charged 8.4 mL of 1.0 M i-PrMgCl/LiCl in THF. The reaction is stirred at 20 C. for 16 hours and cooled to -23 C. 4.3 g of 2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucopyranone in 2 mL of THF is added dropwise. The reaction is then stirred at -20 C. for 2 h. Aqueous NH4Cl solution (25 weight-%, 12 mL) is added to quench the reaction. MTBE (8 mL) is added and the organic layer is separated. The aqueous layer is extracted with EtOAc (30 mL). The combined organic phases are dried over MgSO4 and concentrated.

915095-89-5 (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 15941217, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Boehringer Ingelheim International GmbH; US2006/258749; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.915095-89-5,(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran,as a common compound, the synthetic route is as follows.

915095-89-5, (3S) -3- [4-[(2-chloro-5-iodophenyl) methyl] phenoxy] tetrahydrofuran (1.0 g, 2.72 mmol), tetrahydrofuran (16 mL),PMDTA (1.2mL, 1.5equiv) was added to a 250mL three-necked bottle in sequence, and after replacing the air in the reaction bottle with nitrogen,The temperature of the cold trap is controlled at about -78 C, and 2.5M n-butyllithium (1.6mL, 1.5equiv) is slowly added dropwise and stirred for about 1h.TMS-protected gluconolactone 4 (1.5 g, 1.3 equiv) and toluene (16 mL) were added to another 50 mL round bottom flask and mixed well, and the temperature of the cold trap was controlled at about -78 C.The toluene solution of 4 was slowly dropped into a three-necked flask, keeping the temperature unchanged, and stirred for 2h.Keeping the temperature unchanged, methanol (10 mL) was slowly dropped into a three-necked flask and stirred for 20 min.Then the temperature rose to about -20 C, and a 15% citric acid aqueous solution (50 mL) was slowly dropped into the three-necked flask. After the drop was completed, the temperature was raised to room temperature and stirred for 2 hours.Then, a saturated sodium bicarbonate aqueous solution (100 mL) was slowly dropped into a three-necked flask, and the drop was completed, and stirred for 20 min.Transfer the reaction solution to a 250mL separatory funnel, let stand for layer separation, separate the organic phase, and extract the aqueous phase with ethyl acetate,The organic phases were combined and washed three times with brine, and the organic phase was dried over anhydrous magnesium sulfate.After filtering off the desiccant, the solvent was removed by rotary evaporation to obtain a yellow oil.

As the paragraph descriping shows that 915095-89-5 is playing an increasingly important role.

Reference£º
Patent; Shenyang Pharmaceutical University; Ren Xuhong; Zhang Letian; (8 pag.)CN111040000; (2020); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem