The important role of (R)-(+)-2-Tetrahydrofuroic acid

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HEPATITIS C VIRUS INHIBITORS

The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Optically active tetrahydrofran-2-carboxylic acid manufacturing method (by machine translation)

The issue of the invention is to efficiently manufacture in a high production yield optically active tetrahydrofuran-2-carboxylic acid with optical activity and high purity. The manufacturing method of the optically active tetrahydrofuran-2-carboxylic acid includes three steps: a first step of subjecting (R)- or (S)- tetrahydrofuran-2-carboxylic acid and a salt of an aromatic amine in water to salt exchange by utilization of an inorganic metal alkali, removing the aromatic amine by a hydrocarbon system solvent and/or an ester solvent to obtain a water layer containing the (R)- or (S)- tetrahydrofuran-2-carboxylic acid; a second step of adding an inorganic acid into the water layer obtained in the first step to make the pH to be acid, and extracting with tetrahydrofuran; and a third step of concentrating the extract liquid obtained in the second step and distilling.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Syntheses of optically active 2-tetrahydrofuran derivatives

The resolution of 2-tetrahydrofuran-carboxylic acid and assignment of configuration to the enantiomers are reported.New syntheses of the enantiomers of 2-tetrahydofurancarboxaldehyde are also described.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Final Thoughts on Chemistry for (R)-(+)-2-Tetrahydrofuroic acid

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Optically active tetrahydrofran-2-carboxylic acid manufacturing method (by machine translation)

The present invention provides a method for producing tetrahydrofuran-2-carboxylic acid with high optical activity by using cheap and easy accessible material in industrial. The method for producing optically active tetrahydrofuran-2-carboxylic acid includes reacting a mixture of (R)- and (S)-tetrahydrofuran-2-carboxylic acid with benzylamine, and carrying out crystal precipitation and purification in aliphatic series alcohol with 2 to 4 carbon atoms or mixed solvent of aliphatic series alcohol with 2 to 4 carbon atoms. Thus (R)- or (S)-tetrahydrofuran-2-carboxylic acid with an optical purity larger than 99.0%e.e. is obtained.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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NOVEL COMPOUNDS

The preseent invention relates to novel retinoid-related orphan receptor gamma(RORgamma)modulators and their use in the treatment ofdiseases mediated by RORgamma.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Design, synthesis and biological evaluation of caudatin analogs as potent hepatitis B virus inhibitors

Thirty-nine caudatin analogs were designed and synthesized. Their anti-hepatitis B virus (HBV) activities were evaluated in vitro. Among them, twenty-three compounds showed much better anti-HBV activity than caudatin, and eleven compounds significantly inhibited the HBV DNA replication with IC50 values < 10 muM. Interestingly, three compounds (22, 28, 29) exhibited excellent activity against the secretion of HBsAg (IC50 = 63.02 muM, 52.81 muM, 56.08 muM), HBeAg (IC50 = 204.80 muM, 173.51 muM, 70.39 muM), along with HBV DNA replication (IC50 = 24.55 muM, 5.69 muM, 8.23 muM) with lower cytotoxicity. The structure-activity relationships (SARs) of these caudatin analogs were also discussed. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 87392-05-0, help many people in the next few years.Recommanded Product: 87392-05-0

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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FUSED HETEROCYCLIC RING COMPOUND

A compound represented by the following formula or a salt thereof, which has an GPR119 agonist action, is useful for the prophylaxis or treatment of diabetes, obesity and the like, and shows superior efficacy: wherein P: substituted 6-membered aromatic ring, Q: (substituted) 6-membered aromatic ring, A1: CR4aR4b, NR4c, O, S, SO or SO2 {R4a-4c: H etc.}, L1: (substituted) C1-5 alkylene, L2: a bond or (substituted) C1-3 alkylene, L3-4: (substituted) C1-3 alkylene, R1: H, X, CN, (substituted) hydrocarbon, (substituted) heterocycle or (substituted) OH, or (substituted) 4- to 8-membered (heterocyclic) ring together with A1, R2: H, CN, (substituted) hydrocarbon, and R3a: -COSRA1, (substituted) 5- or 6-membered aromatic ring {RA1: (substituted) hydrocarbon or (substituted) heterocycle}.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Benzothiazole derivatives

This invention relates to compounds of formula I 1 whereinR1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof.It has been found that the compounds of formula I are adenosine receptor ligands with good affinity to the A2A-receptor and a high selectivity to the A1- and A3 receptors. These compounds are useful, inter alia, in treatment of Alzheimer”s disease, depression, Parkinson”s disease and ADHD.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem