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N-Propargylamides having chiral centers at the alpha-carbon of the amide groups, 1-3, were polymerized with (nbd)Rh+[eta6-C6H5B-(C 6H5)3] to afford polymers with moderate molecular weights (Mn = 6000-32 000) in good yield. The 1H NMR spectra demonstrated that the polymers have stereoregular structures (cis = 100%). The polymers were proven to take a helical conformation with an excess of one- handed screw sense in CHCl3, which was supported by their intense CD effects and large optical rotations. It was confirmed that the helical structure was stabilized not only by the steric repulsion but also by the intramolecular hydrogen bonds between the pendant groups. CD spectroscopic study showed that the helical structure is more stable than that of the polymers without a branch at the alpha-position, which allowed the polymers to exist in the helical state in various solvents. The electronic absorption, CD effects, and optical rotations of the polymers closely correlated to the extent of the hydrogen bonding between the pendant amide groups.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 87392-05-0, and how the biochemistry of the body works.Recommanded Product: (R)-(+)-2-Tetrahydrofuroic acid
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem