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The present invention relates to the novel anthelmintic compound tetrahydro-furan-2- carboxylic acid-[3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide and the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, as well as pharmaceutical compositions comprising said novel compound, processes for preparing said compound and compositions, and the use thereof as a medicine, in particular in treatment, control and prevention of endo- and ectoparasite infections in warm-blooded animals.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Eight new tetramic acid glycosides named rubrosides A-H have been isolated from the marine sponge Siliquariaspongia japonica. Their structures were elucidated on the basis of spectral data as tetramic acid glycosides containing polyenes terminating in a 4-chloro-2-methyltetrahydrofuran ring. The absolute stereochemistry of the furan functionality in the two major metabolites, rubrosides D and F, was determined by the NMR method using chiral anisotropic reagents for tetrahydro-2-furoic acid derived by RuO4 oxidation. The absolute stereochemistry of tetramic acid and of the sugar moieties in all rubrosides was deduced by chiral GC analysis of chemical degradation products. The rubrosides induced numerous large intracellular vacuoles in 3Y1 rat fibroblasts at concentrations of 0.5-1.0 mug/mL, and rubrosides A, C, D, and E were cytotoxic against P388 murine leukemia cells with IC50 values of 0.046-0.21 mug/mL. Most rubrosides show antifungal activity against Aspergillus fumigatus and Candida albicans.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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2-Amino-pyrimidine derivatives of formula I, wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine receptor H4antagonists.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The present invention, a compound having antiviral action. And 1 A 1 the, CR 1A R 1B, S or O; A 2 the, CR 2A R 2B, S or O; A 3 the, CR 3A R 3B, S or O; A 4 the, CR 4A R 4B, S or O; Here, A 1, A 2, A 3, A 4, A 1 adjacent to a nitrogen atom, and A 4 adjacent carbon atoms in the hetero atom of the number of atoms constituting, in 1 or 2 ; R 1A and R 1B is, independently, a hydrogen, halogen, alkyl, etc.; or R 2A and R 2B is, independently, a hydrogen, halogen, alkyl, etc.; or R 3A and R 3B is, independently, a hydrogen, halogen, alkyl, etc.; or R 4A and R 4B is, independently, a hydrogen, halogen, alkyl, etc.; or R 3A and R 3B together non-aromatic or non-aromatic heterocyclic ring, a carbon ring may form; The X, CH 2, S or O; R 1 is, independently, halogen or like hydroxyacid; M is an integer of 0-2 N is an integer of 1-2) (by machine translation)

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Tetrahydrofuran – Wikipedia,
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We investigated the structure-activity relationship of KNT-127 (opioid delta agonist) derivatives with various 17-substituents which are different in length and size. The 17-substituent in KNT-127 derivatives exerted a great influence on the affinity and agonistic activity for the delta receptor. While the compounds with electron-donating 17-substituents showed higher affinities for the delta receptor than those with electron-withdrawing groups, KNT-127 derivatives with 17-fluoroalkyl groups (the high electron-withdrawing groups) showed high selectivities for the delta receptor among evaluated compounds. In addition, the basicity of nitrogen as well as the structure of the 17-N substituent such as the length and configuration at an asymmetric carbon atom contributed to agonist properties for the delta receptor. Thus, the analog with a 17-(3-ethoxypropyl) group showed the best selectively and potent agonistic activity for the delta receptor among KNT-127 derivatives. These findings should be useful for designing novel delta selective agonists.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Substituted polycyclic pyridone derivative of the manufacturing method. Formula (I): (In the formula, R1 Is hydrogen, unsubstituted alkyl or other protecting group. ) Shown in compound, and/or magnesium salt in the presence of a sodium salt, Formula: R2 – OH (In the formula, R2 A non-substituted alkyl. ) Is reacted with a compound represented by the, formula (II): (In the formula, R2 The same significance as described above. ) Production of a compound represented. (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Employing the method of asymmetric transformation, the absolute configurations of heterocyclic acids III, IV, Va, and VIIa have been determined.The acids Va and VIIa were chemically correlated with alcohols of known absolute configurations.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Compounds of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem