Category: 87392-05-0

Simple exploration of 87392-05-0

As the paragraph descriping shows that 87392-05-0 is playing an increasingly important role.

87392-05-0, (R)-(+)-2-Tetrahydrofuroic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6.01.17 R-(tetrahydrofuran-2-yl)-methanol 20 g R-tetrahydrofuran-2-carboxylic acid in 60 mL THF was dropped to 6.6 g lithium aluminium hydride in 140 mL THF. The reaction was refluxed until gas formation was stopped. The reaction was coolded with an ice bath and 20 mL water and 10 mL 15N sodiunhydroxide was added. The reaction was stirred 20 min, diluted with 100 mL THF, filltered over magnesiumsulfate and the filtrate was evaporated to give 16.1 g desired product. (M+Na)+: 124 1H-NMR (400 MHZ): 4.6 (1H OH), 3.8; 3.6; 3.3 (5H, CH2, CH, CH2); 1.8; 1.55 (m, 4H, CH2, CH2)., 87392-05-0

As the paragraph descriping shows that 87392-05-0 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; US2013/184248; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 87392-05-0

87392-05-0 (R)-(+)-2-Tetrahydrofuroic acid 2734707, aTetrahydrofurans compound, is more and more widely used in various.

87392-05-0, (R)-(+)-2-Tetrahydrofuroic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(2R)-tetrahydrofuran-2-carboxylic acid (2 g, 17.22 mmol) was dissolved in 20 mL of THF under argon and the flask was cooled in an ice bath, BH3.SMe2 (2M solution in THF, 10 mL, 20.0 mmol) was added to the reaction solution over 10 minutes. The ice bath was removed and the solution was stirred for 1 h at room temperature. The solution was again cooled in an ice bath and methanol slowly added until no gas evolution was observed. The solution was concentrated in vacuum to give the desired product as oil (m = 1 g, 60 %). 1H NMR (300 MHz, CDCI3) delta 1 .55- 1 .70 (m, 1 H), 1 .72-1 .98 (m, 3H), 3.35-4.00 (m, 6H).

87392-05-0 (R)-(+)-2-Tetrahydrofuroic acid 2734707, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; UNIVERSITE DE LILLE 2 DROIT ET SANTE; INSTITUT PASTEUR DE LILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CHARTON, Julie; DEPREZ, Benoit; LEROUX, Florence; STAELS, Bart; MUHR-TAILLEUX, Anne; HENNUYER, Nathalie; LESTAVEL, Sophie; PICON, Sylvain; AKNIN, Karen; BOULAHJAR, Rajaa; DUBANCHET, Barbara; (234 pag.)WO2016/16238; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem