Category: 87392-05-0

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SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1

The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treating fungal infections, for example, with a compound or composition described herein. The antifungal compositions can include antifungal adjuvants such as essential oils or essential oil extracts, which adjuvants further improve the antifungal activity of the compositions.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Design, synthesis and SAR study of novel trisubstituted pyrimidine amide derivatives as CCR4 antagonists

The design, synthesis and structure-Activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibition assay. Compound 1, which we have previously reported as a potent antagonist of CCR4, was employed as the positive control. The results indicated that most of the synthesized compounds exhibited some chemotaxis inhibition activity against CCR4. Of these new compounds, compounds 6c, 12a and 12b, with IC50 values of 0.064, 0.077 and 0.069 muM, respectively, showed higher or similar activity compared with compound 1 (IC50 of 0.078 muM). These compounds provide a basis for further structural modifications. The systematic structure-Activity relationship of these trisubstituted pyrimidine amide derivatives was discussed based on the obtained experimental data. The results from the SAR study may be useful for identifying more potent CCR4 antagonists.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Preparative and Structural Chemistry of Diastereomeric Derivatives of 3-PhosphanylpyrroIidine and Their Palladium(II) Complexes -Asymmetric Grignard Cross-Coupling Reaction

The preparation of both diastereomeric derivatives of 3-(diphenylphosphanyljpyrrolidine with chiral (tetrahydrofuran2-yl}methyl and [(/V-neopentyl)pyrrolidin-2-yl]methyl groups as substituents on the pyrrolidine nitrogen atom and of (2S,4S)-l-benzyl-4-(diphenylphosphanyl)-2-(methoxymethyljpyrrolidine is reported. [3S,P(fiS)]-3-(phenylphosphanyljpyrrolidine, bearing an additional chiral center on phosphorus, is the starting material for the preparation of phosphanes, in which one phenyl group of the PPh2 moiety is substituted by an 2-methoxyphenyl (= An) or 2,4,6-trimethoxyphenyl (= TMP) group. PdI2 complexes of these ligands were separated into diastereomers by chromatography on silica gel columns. The structural chemistry of these novel phosphane diastereomers and their PdI2 complexes is investigated by X-ray crystallography and NMR. At the P,N-coordinated palladium center displacement of an iodide anion is found for P,N,N’ ligands only. In the nickel complex catalysed cross-coupling reaction, yielding 3-phenyl-l-butene, we obtain the highest enantioselectivities in the case of simple l-alkyl-3-(diphenylphosphanyl)pyrrolidine ligands. The enantioselectivity obtained with diastereomeric derivatives, bearing additional ether or amine ligating sites is mainly determined by the chiral center in 3-position of the 3-(phosphanyl)pyrrolidine part of these ligands. Optimisation of enantioselectivity with these ligands can be carried out by a variation of the ligand to nickel ratio and by the choice of the vinyl halide used as starting compound. The catalytic cycle must contain at least one catalytically active species, bearing more than one ss-aminoalkylphosphane ligand. VCH Verlagsgesellschaft mbH,.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A scalable chemoenzymatic preparation of (R)-tetrahydrofuran-2-carboxylic acid

To develop a practical scalable approach to (R)-tetrahydrofuran-2-carboxylic acid (THFC) 1, a chiral building block for furopenem 2, enantioselective hydrolysis of its esters is explored: When ethyl (¡À)-tetrahydrofuran-2-carboxylate 3d (2 M, 288 g/L) is digested by an Aspergillus melleus protease {0.2% (w/v)} in a 1.5 M potassium phosphate buffer (pH 8) for 20 h, enantioselective hydrolysis proceeds with E=60 to give (R)-THFC 1 in 94.4% ee. On separation from the left-over antipodal ester (S)-3d by partition, (R)-THFC 1 is treated with N,N-dicyclohexylamine (DCHA) in methyl ethyl ketone/methanol (5:1) to precipitate the crystalline salt 4 that contains (R)-THFC 1 of >99% ee in 22% overall yield from (¡À)-3d.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: (R)-(+)-2-Tetrahydrofuroic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 87392-05-0, name is (R)-(+)-2-Tetrahydrofuroic acid. In an article£¬Which mentioned a new discovery about 87392-05-0

SPIROPIPERIDINE DERIVATIVES

Described herein are spiropiperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described spiropiperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described spiropiperidine compounds and synthetic intermediates that are useful in those syntheses.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 87392-05-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 87392-05-0, Name is (R)-(+)-2-Tetrahydrofuroic acid, molecular formula is C5H8O3

Synthesis of 3-Azabicyclo[3.2.0]heptane-Derived Building Blocks via [3+2] Cycloaddition

An efficient approach to synthesis of various substituted 3-azabicyclo[3.2.0]heptane-derived building blocks based on [3+2] cycloaddition of cyclobut-1-eneraboxylic acid ester and in situ generated azomethine ylide was developed and applied on multigram scale. The utility of 1,3-disubstituted 3-azabicyclo[3.2.0]heptane scaffold was demonstrated by additional structural analysis using exit vector plot (EVP) tool, and tested in parallel synthesis of compound library.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 87392-05-0, name is (R)-(+)-2-Tetrahydrofuroic acid, introducing its new discovery. category: Tetrahydrofurans

Potent hepatitis C virus NS5A inhibitors containing a benzidine core

Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 87392-05-0, and how the biochemistry of the body works.category: Tetrahydrofurans

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (R)-(+)-2-Tetrahydrofuroic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 87392-05-0, Name is (R)-(+)-2-Tetrahydrofuroic acid, molecular formula is C5H8O3

2-OXO-3,4-DIHYDROPYRIDINE-5-CARBOXYLATES AND THEIR USE

The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H8O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 87392-05-0, Name is (R)-(+)-2-Tetrahydrofuroic acid, molecular formula is C5H8O3

TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS

The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza- benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists

Combination of structural elements from a potent Y5 antagonist (2) with thiazole fragments that exhibit weak Y5 affinities followed by lead optimisation led to the discovery of (5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen-2-yl)- piperidin-4-ylmethyl-amino and (4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2- yl)-piperidin-4-ylmethyl-amino derivatives. Both classes of compounds are capable of delivering potent and selective orally and centrally bioavailable NPY Y5 receptor antagonists.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem