Category: 873063-62-8

Simple exploration of 873063-62-8

As the paragraph descriping shows that 873063-62-8 is playing an increasingly important role.

873063-62-8, (R)-3-Iodotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,873063-62-8

To a 1.00 M solution of lithium hexamethyldisilazide in tetrahydrofuran (34.8 mL, 34.8 mmol) under N2 at -78 C. was added a solution of methyl (1R,4S)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylate (4.0 g, 16 mmol) in tetrahydrofuran (20 mL). The resulting brown solution was stirred at -78 C. for 30 min before adding a solution of (3R)-3-iodotetrahydrofuran (3.75 g, 17.4 mmol) in THF (3 mL). The mixture was stirred for 10 min at -78 C. then kept in a freezer reading at -25 C. overnight. The reaction was quenched with saturated ammonium chloride, extracted with ether three times. The combined extracts were dried (MgSO4), filtered, concentrated and purified by flash column chromatography (EtOAc/Hexane) to provide the desired product (1.6 g, 31%). MS calculated for C16H25NO5: (M+H) 312.2; found 312.2.

As the paragraph descriping shows that 873063-62-8 is playing an increasingly important role.

Reference£º
Patent; Xue, Chu-Biao; Zheng, Changsheng; Feng, Hao; Xia, Michael; Glenn, Joseph; Cao, Ganfeng.; Metcalf, Brian W.; US2006/4018; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

New learning discoveries about 873063-62-8

The synthetic route of 873063-62-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873063-62-8,(R)-3-Iodotetrahydrofuran,as a common compound, the synthetic route is as follows.

[0388] N-(3′-Fluoro-5,6′-dimethyl-2,2′-bipyridin-4-yl)-2H-pyrazolo[4,3-b]pyridin-7-amine (43 mg, 0.129 mmol) was dissolved in DMF (2 mL), cooled to 0C and sodium hydride (4.75 mg, 60%), 0.129 mmol) was added. The reaction mixture was stirred for 5 minutes and (R)-3-iodotetrahydrofuran (25.5 mg, 0.129 mmol) was added and further stirred for 5 minutes at room temperature and then heated in a microwave at 65C for 40 minutes. The reaction mixture was then cooled, concentrated in vacuo to give a residue which was combined with MeOH and filtered. The filtrate was purified by preparative HPLC using a Sunfire Prep 5muiotaeta CI 8, 75 X 30 mm column 5 muiotaeta CI 8, 75 X 30 mm column eluting with a gradient of 5-30% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA) to give the title compounds as TFA salts: (S)-N-(3′-fluoro-5,6′-dimethyl-2,2′-bipyridin-4-yl)- l-(tetrahydrofuran-3-yl)-lH-pyrazolo[4,3-b]pyridin-7-amine 1H NMR (400 MHz,CHLOROFORM- ) delta ppm 1.27 – 1.42 (m, 1 H) 2.36 – 2.39 (m, 4 H) 2.39 – 2.51 (m, 2 H) 2.55 (s, 3 H) 3.80 – 3.89 (m, 1 H) 4.01 (dd, J=9.85, 7.33 Hz, 1 H) 4.11 – 4.22 (m, 2 H) 7.01 (d, J=3.54 Hz, 1 H) 7.14 (dd, J=8.46, 3.41 Hz, 1 H) 7.31 – 7.44 (m, 2 H) 8.25 (s, 1 H) 8.41 (br. s., 1 H), MS [M+H] found 405.4; and (S)-N-(3*-fluoro-5,6*-dimethyl-2,2,-bipyridin-4-yl)- l-(tetrahydrofuran-3-yl)-lH-pyrazolo[4,3-b]pyridin-7-amine 1H NMR (400 MHz,CHLOROFORM-;/) delta ppm 2.44 (s, 3 H) 2.46 – 2.56 (m, 1 H) 2.57 – 2.70 (m, 4 H) 4.04 (td, J=8.59, 5.56 Hz, 1 H) 4.18 – 4.31 (m, 3 H) 5.22 – 5.33 (m, 1 H) 7.02 (d, J=5.05 Hz, 1 H) 7.13 – 7.23 (m, 2 H) 7.43 (dd, J=10.48, 8.46 Hz, 1 H) 8.13 (d, J=1.26 Hz, 1 H) 8.26 (s, 1 H) 8.41 (d, J=5.05 Hz, 1 H) 8.62 (s, 1 H), MS [M+H] found 405.4.

The synthetic route of 873063-62-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KWOK, Lily; LARSON, John David; SABAT, Mark; WO2011/146287; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem