Category: 77341-67-4

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Identification of monomenthyl succinate, monomenthyl glutarate, and dimenthyl glutarate in nature by high performance liquid chromatography-tandem mass spectrometry, published in 2004-06-02, which mentions a compound: 77341-67-4, Name is 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, Molecular C14H24O4, SDS of cas: 77341-67-4.

Menthol, menthone, and other natural compounds provide a cooling effect and a minty flavor and found wide application in chewing gum and oral care products. Monomenthyl succinate, monomenthyl glutarate, and dimenthyl glutarate provide a cooling effect without the burning sensation associated with menthol. Addnl., because they do not have a distinct flavor, they can be used in applications other than mint flavors. Because these menthyl esters were not reported in nature, the authors undertook to identify a natural source for these cooling compounds Using HPLC-tandem mass spectrometry, monomenthyl succinate was identified in Lycium barbarum and Mentha piperita, and monomenthyl glutarate and dimenthyl glutarate were identified in Litchi chinensis. The identifications were based on the correlation of mass spectrometric and chromatog. retention time data for the menthyl esters in the extracts with authentic standards which resulted in a 99.980% confidence in the identifications.

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)SDS of cas: 77341-67-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Koseki, Yoshitaka; Ikuta, Yoshikazu; Cong, Liman; Takano-Kasuya, Mayumi; Tada, Hiroshi; Watanabe, Mika; Gonda, Kohsuke; Ishida, Takanori; Ohuchi, Noriaki; Tanita, Keita; Taemaitree, Farsai; Dao, Anh Thi Ngoc; Onodera, Tsunenobu; Oikawa, Hidetoshi; Kasai, Hitoshi researched the compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ).Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.They published the article 《Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity》 about this compound( cas:77341-67-4 ) in Bulletin of the Chemical Society of Japan. Keywords: prodrug SN38 hydrophobicity cancer antitumor. We’ll tell you more about this compound (cas:77341-67-4).

In the field of drug delivery, controllability of drug release site and duration are among the most important factors to manipulate the drug efficacy and side effects. In this paper, a series of nano-prodrugs (NPs) composed of anticancer agent SN-38 and various substituent groups were synthesized and fabricated. By increasing the hydrophobicity of the prodrug mol. (calculated logP values exceeded ca. 7) through changing the substituent group, the hydrolysis susceptibility of SN-38 NPs in mouse serum was drastically decreased, thus prolonged the blood retention time of the NPs. In light of this knowledge and the dispersion stability in aqueous media, SN-38 NP modified with cholesterol (SN-38-chol NPs) was selected to be the optimal candidate among the screened NPs. The in vivo pharmacol. effect of SN-38-chol NP was about 10 times higher than irinotecan, the clin. used solubilized prodrug analog of SN-38. In addition, SN-38-chol NP has low side effects in evaluating intestinal damage. These NPs possess great potential for clin. application and promise to be a next-generation of drug for cancer treatment.

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The effect of the position of chiral (-)-menthyl on the formation of blue phase and mesophase behavior in biphenyl-benzoate liquid crystals, published in 2020-01-15, which mentions a compound: 77341-67-4, mainly applied to menthyloxyoxoalkanoyloxy biphenylylbutoxybenzoate preparation crystal structure, Electric Literature of C14H24O4.

Eight new chiral liquid crystal compounds 4-(4-menthyloxy-n-oxoalkanoyloxy)biphenyl-4′-yl 4-butoxybenzoates I [n = 1, 2, 3, 4, etc.], were prepared by modifying the position of chiral (-)-menthyl in the menthol based liquid crystal compounds through gradually increasing the alkyl chain length of the dicarboxylic spacer. All compounds were characterized by FT-IR and NMR spectroscopy in order to prove their chem. structures. Differential scanning calorimetry (DSC), polarized optical microscopy (POM) and X-ray diffraction were carried out to systematically investigate their phase transition behaviors. The position of chiral (-)-menthyl in relation to the core effected on the formation of BPs and mesomorphic behaviors. Only CLCs I [n = 1, 2] with short spacer chains presented blue phases. Furthermore, the length and parity of the flexible spacers showed profound influence on phase structures and phase transition behaviors. An odd-even effect was observed for these chiral liquid crystal compounds

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Electric Literature of C14H24O4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Identification of monomenthyl succinate, monomenthyl glutarate, and dimenthyl glutarate in nature by high performance liquid chromatography-tandem mass spectrometry, published in 2004-06-02, which mentions a compound: 77341-67-4, Name is 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, Molecular C14H24O4, SDS of cas: 77341-67-4.

Menthol, menthone, and other natural compounds provide a cooling effect and a minty flavor and found wide application in chewing gum and oral care products. Monomenthyl succinate, monomenthyl glutarate, and dimenthyl glutarate provide a cooling effect without the burning sensation associated with menthol. Addnl., because they do not have a distinct flavor, they can be used in applications other than mint flavors. Because these menthyl esters were not reported in nature, the authors undertook to identify a natural source for these cooling compounds Using HPLC-tandem mass spectrometry, monomenthyl succinate was identified in Lycium barbarum and Mentha piperita, and monomenthyl glutarate and dimenthyl glutarate were identified in Litchi chinensis. The identifications were based on the correlation of mass spectrometric and chromatog. retention time data for the menthyl esters in the extracts with authentic standards which resulted in a 99.980% confidence in the identifications.

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)SDS of cas: 77341-67-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Belkacemi, Fatima Zohra; Merabet-Khelassi, Mounia; Aribi-Zouioueche, Louisa; Riant, Olivier published the article 《Production of L-menthyl acetate through kinetic resolution by Candida cylindracea lipase: effects of alkaloids as additives》. Keywords: lipase kinetic resolution menthyl acetate alkaloid.They researched the compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ).Safety of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:77341-67-4) here.

Abstract: Enzymic transesterification of dL-menthol with vinyl acetate in tert-Bu Me ether (TBME) catalyzed by Candida cylindracea lipase (CCL) was carried out in the presence of cinchona alkaloid as additive. The effects of various reaction parameters, such as lipase nature and loading, acylating agent, mol. sieves, solvents and various additives, on the reactivity as well as on the enantioselectivity were investigated. A significant improvement of CCL reactivity has been recorded after using cinchona alkaloid as additive in TBME. A high enantiomeric ratio (E = 80) was achieved when 30 mol% of quinidine was added, and L-(-)-menthyl acetate was obtained with 93% optical purity and 49% conversion. This process was easily applied to gram-scale quantities, using com. inexpensive lipase, providing high yield optically active menthol under mild exptl. conditions.

As far as I know, this compound(77341-67-4)Safety of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 77341-67-4, is researched, Molecular C14H24O4, about Synthesis and Characterization of a Series of Cholesterol-Based Liquid Crystalline Dimers with a Chiral (-)- Menthyl Terminal Group, the main research direction is cholesterol menthyl dihydroxybiphenyl conjugate preparation esterification; menthyl cholesterol conjugate chiral nematic liquid crystalline dimer dimesogenic.COA of Formula: C14H24O4.

A novel series of cholesterol-based liquid crystalline (LC) dimers with a menthyl terminal group in the biphenyl base side have been synthesized. The chem. structures and LC properties of this series of compounds are characterized by FT-IR, 1H-NMR, elemental anal., hot-stage coupled polarizing microscopy and differential scanning calorimetry. All the dimers exhibit enantiotropic mesophases. These dimesogenic compounds with a short spacer are chiral nematic LCs, while with long spacers, they are SmA and chiral nematic LCs. Some of these LC dimers exhibit iridescent colors in their chiral nematic (N*) states.

As far as I know, this compound(77341-67-4)COA of Formula: C14H24O4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The effect of terminal alkoxy chain on mesophase behaviour, optical property and structure of chiral liquid crystal compounds derived from (-)-menthol, published in 2017, which mentions a compound: 77341-67-4, Name is 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, Molecular C14H24O4, Reference of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.

Herein, the results of the extensive investigations on the synthesis and phase behavior of nine novel (-)-menthol-based chiral liquid crystal compounds is reported. They possess three Ph rings and substituted with (-)-menthyl and varying length of n-alkoxy chains at one end. With the aim of exploring the fundamental relationships between mol. structural features and thermal properties, nine terminal n-alkoxy groups from ethoxy to n-octadecaneloxy group in even numbers have been used. A detailed characterization of their properties was carried out. The characterization results clearly illustrate that all the series compounds show the thermodynamically stable phases; the shorter chain homologues display only the BPI and N* phases, and the middle ones exhibit BPI, N* and SA* phases while the longer chain members show the BPI, N* and SC* phases. Besides, the BPI appeared in a narrow temperature range because of their thermodn. disruption. Temperature range of the N* phase narrows when the length of the n-alkoxy tail increases. The reflection peak is shifted towards short wavelength region with increasing temperature due to the winding of the chiral nematic helix in the N* phase. Furthermore, their inherent reflection peak intensities of reflections were gradually weakened.

As far as I know, this compound(77341-67-4)Reference of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zeitschrift fuer Metallkunde called Density determination of metals and alloys at high temperature with special consideration of the molten state. IV. Measurements according to the buoyancy method. The binary systems antimony-tin and antimony-aluminium, and the metals silver and magnesium, Author is Sauerwald, F., which mentions a compound: 77341-67-4, SMILESS is CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(O)=O, Molecular C14H24O4, Recommanded Product: 77341-67-4.

cf. C. A. 16, 3844. The deviation of sp. volume from the rule of mixture for the Sb-Zn alloys in the molten condition, as well as at high temperatures, is due to Zn3Sb2 which exists in the molten alloys. The sp. volumes of all Sb-Zn alloys over the temperature range 20-800° show a maximum between 35 and 75% Sb. The variation in expansion of the solid Al-Sb alloys observed at high temperatures was not found in the fluid state. The almost complete decomposition of the compound AlSb, beginning at 940°, together with other facts indicates the necessity for a revision of the equilibrium diagram; a temporary revision is offered. The sp. volume of solid and molten silver is a linear function up to 900° and then rises sharply to 1100°. Arguments are given in support of the use of magnesia crucibles in this work as containers for the NaCl-KCl salt bath. The sp.volumeofMg at 780°is 0.566.

This literature about this compound(77341-67-4)Recommanded Product: 77341-67-4has given us a lot of inspiration, and I hope that the research on this compound(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol. Author is Zhang, Tianyuan; Zheng, Shumin; You, Shuyan; Huang, Danling; Cheng, Yong-Xian.

Twelve Novel compounds I[ R1=R2 = H, CH3, Cl etc], II[ R1= R2 = H, CH3, Cl etc] derived from (-)-menthol and (-)-borneol were designed, synthesized and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these novel compounds I and II against Botrytis cinerea, Curvularia lunata and Alternaria alternata were evaluated. The results indicated that II[ R1 = R2 = F] displayed potential fungicidal activities against B. cinerea and C. lunata. Especially, II[ R1 = R2 = F] exhibited IC50 value of 22.9 mg/L against C. lunata, which was higher fungicidal activity than com. product hymexazol and amicarthiazol. In addition, the superficial structure-activity relationship were discussed. This study provided a structural template for the design of novel fungicides.

In addition to the literature in the link below, there is a lot of literature about this compound(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Safety of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, illustrating the importance and wide applicability of this compound(77341-67-4).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Interchange of alcohol radicals in esters. II》. Authors are Shimomura, Akira; Cohen, J. B..The article about the compound:4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acidcas:77341-67-4,SMILESS:CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(O)=O).Quality Control of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid. Through the article, more information about this compound (cas:77341-67-4) is conveyed.

cf. C. A. 16, 2502. The acid nature of an alkyl ester seems to promote the interchange of groups. The introduction of the following groups generally helps the reaction: Ph, Ac, AcO, PhO, CO2H, NO2. Halogens do not materially affect the interchange. In some cases a double bond does. Most of the esters of α-ketonic acids undergo interchange, due, undoubtedly, to the presence of the CO group in the α-position to the CO2H group. The HO group is not favorable to the interchange. In the case of esters of BzH derivatives, o- and p-compounds behave similarly but differ from the m-compound The following new esters are described: l-Menthyl acetylpyruvate, b12 185-92°, [α]D1872.3° ; monoacetylmalonate, long needles, m. 58°, [α]D19 -77.5°; phenoxy-malonate, microneedles, m. 96° [α]D17-55.5°; ethoxymethylevemalonate, b10 215-21°, [α]D20- ; hydrogen succinate, prisms, m. 57-9°, [α]D17 -61.0°.

I hope my short article helps more people learn about this compound(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Quality Control of 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid. Apart from the compound(77341-67-4), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem