Category: 77341-67-4

Synthetic Route of C14H24O4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about The effect of various functional groups on mesophase behavior and optical property of blue phase liquid crystal compounds based on (-)-menthol. Author is Luo, Cong-Cong; Sun, Shu-Li; Wang, Yi-Su; Meng, Fan-Bao; Hu, Jian-She; Jia, Ying-Gang.

In order to explore the effect of various functional groups on the mesomorphic properties, a series of menthol-based blue phase liquid crystal compounds (A, B1, B2, C1, C2, D1, D2) with various core structures in the mols. were synthesized. Their chem. structures and phase behavior were characterized with FT-IR, 1H NMR, differential scanning calorimeter (DSC) and polarizing optical microscopy (POM). The selective reflection and photoisomerization were investigated with UV/visible (UV/VIS) spectrometer. In our case, all BPLCs showed oily streak texture with selectively reflection and blue phase (BP), irresp. of the structure of mesogenic cores. This demonstrated that (-)-menthol had high chirality, and via succinyloxy spacer group could drive mols. to arrangement in double twist cylinders of BP. The length-to-diameter ratio, the bridge bond in the aryl rings and the conjugate action in the mesogenic core had a significant effect on Tm, Ti and temperature range of BP. BPLC A without conjugated structure in three-benzene mesogenic core revealed a larger temperature range of BP than other BPLCs with conjugated structure.

Different reactions of this compound(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Synthetic Route of C14H24O4 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ) is researched.Electric Literature of C14H24O4.Omata, Tetsuo; Iwamoto, Noritada; Kimura, Tomio; Tanaka, Atsuo; Fukui, Saburo published the article 《Stereoselective hydrolysis of dl-menthyl succinate by gel-entrapped Rhodotorula minuta var. texensis cells in organic solvent》 about this compound( cas:77341-67-4 ) in European Journal of Applied Microbiology and Biotechnology. Keywords: heptane menthol succinate Rhodotorula; polyurethane menthol succinate Rhodotorula; resolution menthol succinate Rhodotorula. Let’s learn more about this compound (cas:77341-67-4).

The compound dl-menthyl succinate [75363-56-3] was hydrolyzed stereoselectively by R. minuta texensis cells trapped in photo-crosslinked or polyurethane resin gels in water-saturated n-heptane [142-82-5]. The hydrolyzed product was pure l-menthol [2216-51-5]. The catalytic activity of the immobilized cells, especially those trapped in urethane polymers, was far more stable than that of the free cells. The 1/2-life of the polyurethane-entrapped cells was 55-63 days in the organic solvent.

Different reactions of this compound(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Electric Literature of C14H24O4 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C14H24O4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about On-line investigation of the pyrolysis behavior of monomenthyl succinate by pyrolysis-gas chromatography-mass spectrometry. Author is Wu, Yi-Qin; Yang, Liu; Liu, Fang; Miao, Ming-Ming; Zhu, Hong-You.

The pyrolysis behavior of monomenthyl succinate was investigated by online pyrolysis-gas chromatog.-mass spectrometry (PyGC-MS) in the presence of helium. GC-MS was used for the qual. and semi-quant. anal. of the pyrolysis products of the compound at 300°, 400°, 500°, 600°, 700°, 800°, and 900°. There are altogether 75 pyrolysis products were detected, including menthol, p-menth-3-ene and succinic acid. Flavorous and refreshing substances, such as menthol, p-menth-3-ene and 3-methyl-6-isopropyl-cyclohexene, were released from parent compound under 700°. However, above this temperature, flavor was not found in the pyrolysis products. Moreover, with the raise of pyrolysis temperature, complicated pyrolysis products appeared, and the content of harmful substances, such as benzene, anthracene, and fluoranthene, were also increased. This method possesses the merits of easy operation and good repeatability (RSD < 2.0%). According to the relative content and category of the pyrolysis products, the possible pyrolysis mechanism of monomenthyl succinate was also discussed. The article 《On-line investigation of the pyrolysis behavior of monomenthyl succinate by pyrolysis-gas chromatography-mass spectrometry》 also mentions many details about this compound(77341-67-4)COA of Formula: C14H24O4, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid(SMILESS: CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(O)=O,cas:77341-67-4) is researched.Reference of 8-Bromoguanine. The article 《Tuning the colour of glassy cholesteric liquid crystals using copolymerization of two left-handed menthyl- and cholesteryl-based mesogenic monomers》 in relation to this compound, is published in Liquid Crystals. Let’s take a look at the latest research on this compound (cas:77341-67-4).

A new series of polysiloxane glassy cholesteric liquid crystal copolymers with menthyl- and cholesteryl-based mesogenic units in the side chains, P-MtxChy denoted as (x, y expresses the molar ratio of monomers and in Mt and Ch copolymeric synthesis, and x + y = 7.) were successfully synthesized by hydrosilylation reaction. The mesomorphic properties and phase behaviors were studied by differential scanning calorimetry, polarising optical microscopy and X-ray diffraction. Optical properties were investigated by the UV-VIS spectrum. Using the volume-excluding action of mesogenic units in side chains, we obtained glassy cholesteric liquid crystal copolymers. By varying molar ratio of Mt and Ch in copolymers, the helical pitch was adjusted into visible light region. With the increase of Mt, the maximum reflection wavelength off normal 8° shifted from 548 nm of P-Mt3Ch4 to 650 nm of P-Mt4Ch3 to 872 nm of P-Mt5Ch2, and the reflected colors changed from green to red. These well-oriented glassy films have shown good morphol. stability below the glass-transition temperature (Tg) for more than a year.

After consulting a lot of data, we found that this compound(77341-67-4)HPLC of Formula: 77341-67-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhongguo Tiaoweipin called A new method for synthesis of monomenthyl succinate, Author is Chen, Lei; Yan, Rian; Du, Shuxia; Huang, Caihuan; Duan, Hanying; Liu, Yanqiong, which mentions a compound: 77341-67-4, SMILESS is CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(O)=O, Molecular C14H24O4, Recommanded Product: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.

The method is dissolving menthol and succinic anhydride in chloroform according to some proportion, and reacting under catalyzing by 4-DMAP at 50°C for 12 h, washing the product with saturated NaCl solution, then drying with anhydrous bitter salt and concentrating Monomenthyl succinate was obtained when the condensate was purified with silica gel chromatog. It’s m.p. is 61-63°C. Monomenthyl succinate was proved by IR spectrum and MS. New method for synthesis of monomenthyl succinate is provided by this research.

After consulting a lot of data, we found that this compound(77341-67-4)Recommanded Product: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C14H24O4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about A molecular approach to flavor synthesis. I. Menthol esters of varying size and polarity. Author is Jabloner, H.; Dunbar, B. I.; Hopfinger, A. J..

For a series of menthol esters of increasing size and polarity, mintyness decreased rapidly as mol. weight increased. For mol. weights above ∼700, the compounds were tasteless to a significant proportion of the taste panel. As polarity increased, the sweet minty taste of hydrophobic menthol esters became increasingly bitter, until water-soluble menthol esters were strongly bitter. Bitterness was still apparent in quite high-mol.-weight water-soluble esters; a different receptor may be involved for bitterness than for mint. An overall hypothesis relating flavor to mol. solubility parameters is proposed.

After consulting a lot of data, we found that this compound(77341-67-4)Computed Properties of C14H24O4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ) is researched.COA of Formula: C14H24O4.Puetzer, Bruno; Moran, Wm. J. published the article 《Separation of l-menthol from racemic menthol U.S.P.》 about this compound( cas:77341-67-4 ) in Journal of the American Pharmaceutical Association (1912-1977). Keywords: MENTHOL. Let’s learn more about this compound (cas:77341-67-4).

Purel-menthol was obtained in an overall yield of 61% of the theoretical from dl-menthol employing l-ephedrine (I) as the resolving agent for the acid succinate, essentially as follows. Convert dl-menthol to dl-menthyl H succinate (II) by Arth’s method (Ann. 1, 483 (1832)). Dissolve 75.5 g. II and 50.0 g. I in 500 ml. iso-PrOAc by stirring at 75°, allow to cool slowly, let stand 4 hrs. at room temperature, filter with suction, wash with the solvent, recrystallize twice from b. iso-PrOAc to obtain 46.1 g. l-ephedrine l-menthyl succinate (III), [α]D25 -57.5° (in 95% alc.). The use of other solvents (e.g., acetone, water) resulted in appreciably lower yields. Dissolve 35.5 g. III in 200 ml. CHCl3, extract successively with 100, 100, 50 and 50 ml. 10% HCl, dry the CHCl3 solution over anhydrous Na2SO4, and remove the solvent under reduced pressure leaving 18.7 g. l-menthyl H succinate (IV), m. 60-2°. Dissolve 18.7 g. IV in 150 ml. 10% NaOH, and steam distil to obtain 10 g. l-menthol; filter, dry over H2SO4, and distil at atm. pressure to obtain 9.5 g. l-menthol, b. 212°, m. 41-2°, [α]D25 -50° (in 95% alc.). The odor of this material lacks the aromatic qualities imparted to natural menthol by impurities carried over from oil of peppermint.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C14H24O4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about Synthesis and properties of new (-)-menthol-derived chiral liquid crystal compounds with alkyl or alkoxy terminal groups. Author is Jia, Ying-Gang; Luo, Cong-Cong; Zhu, Zhao-Xia; Hu, Jian-She.

Two series of chiral mesogenic compounds derived from (-)-menthol with varying length of alkyl or alkoxy terminal groups resp. were designed and synthesized. Their chem. structures were characterized by FT-IR and 1H-NMR spectra. The thermal properties and optical textures were investigated by differential scanning calorimetry and polarizing optical microscopy. Bragg selective reflection spectra of the compounds with the alkoxy chain in the N* phase were measured by UV/visible spectrometer. The results showed that the alkyl series homologues melt directly to the isotropic phase on heating and display cubic blue phase and focal conic textures of chiral nematic phase on cooling, whereas the alkoxy series displayed oily streak textures with iridescent colors on heating, and platelet textures of blue phase and focal conic textures were observed on cooling cycles. The chain structure and length of the terminal groups have profound influence on the isotropic temperature and a large odd-even effect is observed for the compounds The selective reflection colors of alkoxy series shifted to longer wavelength with the increasing of temperature

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The effect of the position of chiral (-)-menthyl on the formation of blue phase and mesophase behavior in biphenyl-benzoate liquid crystals, published in 2020-01-15, which mentions a compound: 77341-67-4, mainly applied to menthyloxyoxoalkanoyloxy biphenylylbutoxybenzoate preparation crystal structure, Electric Literature of C14H24O4.

Eight new chiral liquid crystal compounds 4-(4-menthyloxy-n-oxoalkanoyloxy)biphenyl-4′-yl 4-butoxybenzoates I [n = 1, 2, 3, 4, etc.], were prepared by modifying the position of chiral (-)-menthyl in the menthol based liquid crystal compounds through gradually increasing the alkyl chain length of the dicarboxylic spacer. All compounds were characterized by FT-IR and NMR spectroscopy in order to prove their chem. structures. Differential scanning calorimetry (DSC), polarized optical microscopy (POM) and X-ray diffraction were carried out to systematically investigate their phase transition behaviors. The position of chiral (-)-menthyl in relation to the core effected on the formation of BPs and mesomorphic behaviors. Only CLCs I [n = 1, 2] with short spacer chains presented blue phases. Furthermore, the length and parity of the flexible spacers showed profound influence on phase structures and phase transition behaviors. An odd-even effect was observed for these chiral liquid crystal compounds

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Koseki, Yoshitaka; Ikuta, Yoshikazu; Cong, Liman; Takano-Kasuya, Mayumi; Tada, Hiroshi; Watanabe, Mika; Gonda, Kohsuke; Ishida, Takanori; Ohuchi, Noriaki; Tanita, Keita; Taemaitree, Farsai; Dao, Anh Thi Ngoc; Onodera, Tsunenobu; Oikawa, Hidetoshi; Kasai, Hitoshi researched the compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ).Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.They published the article 《Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity》 about this compound( cas:77341-67-4 ) in Bulletin of the Chemical Society of Japan. Keywords: prodrug SN38 hydrophobicity cancer antitumor. We’ll tell you more about this compound (cas:77341-67-4).

In the field of drug delivery, controllability of drug release site and duration are among the most important factors to manipulate the drug efficacy and side effects. In this paper, a series of nano-prodrugs (NPs) composed of anticancer agent SN-38 and various substituent groups were synthesized and fabricated. By increasing the hydrophobicity of the prodrug mol. (calculated logP values exceeded ca. 7) through changing the substituent group, the hydrolysis susceptibility of SN-38 NPs in mouse serum was drastically decreased, thus prolonged the blood retention time of the NPs. In light of this knowledge and the dispersion stability in aqueous media, SN-38 NP modified with cholesterol (SN-38-chol NPs) was selected to be the optimal candidate among the screened NPs. The in vivo pharmacol. effect of SN-38-chol NP was about 10 times higher than irinotecan, the clin. used solubilized prodrug analog of SN-38. In addition, SN-38-chol NP has low side effects in evaluating intestinal damage. These NPs possess great potential for clin. application and promise to be a next-generation of drug for cancer treatment.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem