Category: 76632-23-0

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The rearrangement of 2,4-dimethylthiazole 3-oxide with acetic anhydride》. Authors are Anderson, Hugh J.; Barnes, Douglas J.; Khan, Zahir M..The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Name: (2-Methylthiazol-4-yl)methanol. Through the article, more information about this compound (cas:76632-23-0) is conveyed.

The rearrangement in Ac2O of 2,4-dimethylthiazole 3-oxide produced 2-acetoxymethyl-4-methylthiazole and 4-acetoxymethyl-2-methylthiazole in the ratio of about 4.5 to 1. The same type of rearrangement with 4-methylthiazole 3-oxide gave both 4-acetoxymethylthiazole and 2-acetoxy-4-methylthiazole, but in poor yields. The structure of the sulfate salt of 2,4-dimethylthiazole 3-oxide was established.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and cytotoxic evaluation of some structural fragments of epothilone A, published in 2002-09-30, which mentions a compound: 76632-23-0, mainly applied to epothilone A fragment preparation cytotoxicity, Recommanded Product: 76632-23-0.

The epothilones are a series of macrocyclic lactones with cytotoxic activity. Fragments of epothilone A were prepared and evaluated for cytotoxic activity in order to try to determine the active part of the epothilone structure. The fragments prepared, I [R = HOCHMe, tetrahydro-2-pyranyl, HOCHMeCH2CO2CH2, Me2CH(CH2)3CH:CH(CH2)2 (5)] and 5 diepoxide, did not display bioactivity.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new meso-ionic compounds by the reaction of N-substituted thioamides with α-halo carboxylic acids》. Authors are Ohta, Masaki; Chosho, Hirohide; Shin, Chungi-Gi; Ichimura, Kunihiro.The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Computed Properties of C5H7NOS. Through the article, more information about this compound (cas:76632-23-0) is conveyed.

The reaction between N-substituted thioamides and α-halo carboxylic acids has been described. For the purpose of synthesizing new meso-ionic compounds having a ring system of monocyclic 4-thiazolone, thiobenzanilide and bromoacetic acid were heated in C6H6 according to Holmberg’s paper (CA 45, 581d). The product which was considered to be 2,3-diphenylthiazolium hydroxide was found to be S-benzoylthioglycolanilide by infrared (IR) spectrum and by mixed melting point method. When the reaction was carried out in the presence of Et3N in C6H6 an oily product was obtained. On treatment of this product with Ac2O, a meso-ionic compound was obtained, the structure of which was deduced from considerations of its analysis, IR spectrum, and chem. properties. Compounds having the same ring system can be obtained from other N-substituted thioamides and α-halo carboxylic acids.

In some applications, this compound(76632-23-0)Computed Properties of C5H7NOS is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2-Methylthiazol-4-yl)methanol, is researched, Molecular C5H7NOS, CAS is 76632-23-0, about Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.Recommanded Product: (2-Methylthiazol-4-yl)methanol.

Improved, streamlined total syntheses of natural tubulysins such as V and U, I (R = β-OH, β-OAc, resp.), and pretubulysin D I (R = H), and their application to the synthesis of designed tubulysin analogs, are described. Cytotoxicity evaluation of the synthesized compounds against certain cancer cell lines revealed a number of novel analogs with exceptional potencies [e.g., II: IC50 = 40 pM against MES SA (uterine sarcoma) cell line; IC50 = 6 pM against HEK 293T (human embryonic kidney cancer) cell line; and IC50 = 1.54 nM against MES SA DX (MES SA with marked multidrug resistance) cell line]. These studies led to a set of valuable structure-activity relationships that provide guidance to further mol. design, synthesis, and biol. evaluation studies. The extremely potent cytotoxic compounds discovered in these investigations are highly desirable as potential payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2-Methylthiazol-4-yl)methanol(SMILESS: OCC1=CSC(C)=N1,cas:76632-23-0) is researched.Recommanded Product: 16400-32-1. The article 《Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:76632-23-0).

N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for human African trypanosomiasis (HAT) or sleeping sickness. The authors have previously validated T. brucei NMT as a promising druggable target for the treatment of HAT in both stages 1 and 2 of the disease. The authors report on the use of the previously reported DDD85646 as a starting point for the design of a class of potent, brain penetrant inhibitors of T. brucei NMT.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application In Synthesis of (2-Methylthiazol-4-yl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2-Methylthiazol-4-yl)methanol, is researched, Molecular C5H7NOS, CAS is 76632-23-0, about Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385. Author is Miller, John F.; Andrews, C. Webster; Brieger, Michael; Furfine, Eric S.; Hale, Michael R.; Hanlon, Mary H.; Hazen, Richard J.; Kaldor, Istvan; McLean, Ed W.; Reynolds, David; Sammond, Douglas M.; Spaltenstein, Andrew; Tung, Roger; Turner, Elizabeth M.; Xu, Robert X.; Sherrill, Ronald G..

A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clin. candidate GW0385.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem