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The methanolic extract of saffron was separated with the aid of multilayer coil countercurrent chromatography. After purification by HPLC, the following seven novel carotenoid metabolites were identified on the basis of their spectral (UV, FTIR, MS, NMR, CD) data: (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-enecarbaldehyde O-beta-D-gentiobioside (1), (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-enecarboxylic acid O-beta-D-glucopyranoside (2), 6-hydroxy-3-(hydroxymethyl)-2,4,4-trimethylcyclohexa-2,5-dienone 6-O-beta-D-glucopyranoside (3), (2Z)-3-methylpent-2-enedioic acid 1-[1-(2,4,4-trimethyl-3,6-dioxocyclohexenyloxy)-O-beta-D-glucopyranosid-6-yl] ester (4), (5S)-5-hydroxy-7,7-dimethyl-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one O-beta-D-glucopyranoside (5), (1R,5S,6R)-5-(hydroxymethyl)-4,4,6-trimethyl-7-oxabicyclo[4.1.0]heptan-2-one O-beta-D-glucopyranoside (6), and (1R)- 3,5,5-trimethylcyclohex-3-enol O-beta-D-glucopyranoside (7).

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Tetrahydrofuran – Wikipedia,
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A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.

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Tetrahydrofuran – Wikipedia,
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High concentrations of the acid-insoluble residue (AIR, also known as “Klason lignin”) in decomposing litter are considered to indicate high resistance to decomposition; however, the chemical composition of AIR in different types of litter and soil organic matter is poorly understood. In the present study, we characterized samples of common litter (L) types in boreal forests (needle, coarse tree, and moss), as well as fragmented litter (F), and humus (H) layers in two south boreal forest sites using a combination of sequential fractionation and pyrolysis-GC-MS. The results showed that the unfractionated samples were composed of cellulose-derived carbohydrates, guaiacyl-type lignin and other polyphenolic compounds, and that there was little variation among samples. However, pyrolysis-GC-MS analyses of AIR demonstrated that the composition of the AIR fraction differed among the analyzed litter materials as well as between the layers in the soil organic horizon. In the F and H layers, the AIR fraction contained guaiacyl-type lignin and other polyphenolics, as well as lipophilic compounds, which were indicated by the pyrolysis product methyldehydroabietate and short-chain fatty acids. In the AIR fraction, only small amounts of carbohydrate-derived compounds were detected, confirming that the sequential fractionation method efficiently removes soluble polysaccharides. The AIR fraction was poorly soluble in all solvents. The results presented here confirm that the sequential fractionation method efficiently separates water-, chloroform-, and acid-soluble (72% H2SO4) compounds from acid-insoluble compounds (AIR). However, AIR was shown to be a mixture of polyphenolic (mainly lignin-derived) and lipophilic (including fatty acids and resin acid) structures, and may therefore be a poor indicator of lignin and phenolic compounds when investigating the F and H layers in the organic horizon.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Numerous biologically active natural products contain furanoses and pyranoses with mono- and dihydroxylated substituents. However, much of the structure-activity studies on such molecules is gathered on the aglycons without attention to the corresponding carbohydrate components. Consequently, there are few synthetic procedures that enable the rapid preparation of mono- and dihydroxyfuranoses and mono- and dihydroxypyranoses and no report for a 3,4-dihydroxyoxepanose. In this article we report the practical synthesis of orthogonally protected five-, six-, and seven-membered carbohydrate derivatives. The succinct manner in which these molecules were synthesized allows the rapid preparation of analogues aimed at discovering the role of ring size and individual hydroxyl moieties on the pyranose skeleton.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Authenticity assessment of flavoured strawberry foods was performed using headspace-solid phase microextraction (HS-SPME) coupled to gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS). An authenticity range was achieved, investigating on the carbon isotope ratio of numerous selected aroma active volatile components (methyl butanoate, ethyl butanoate, hex-(2E)-enal, methyl hexanoate, buthyl butanoate, ethyl hexanoate, hexyl acetate, linalool, hexyl butanoate, octyl isovalerate, gamma-decalactone and octyl hexanoate) of organic Italian fresh strawberries. To the author’s knowledge, this is the first time that all these components were investigated simultaneously by GC-C-IRMS on the same sample. The results were compared, when applicable, with those obtained by analyzing the HS-SPME extracts of commercial flavoured food matrices. In addition, one Kenyan pineapple and one fresh Italian peach were analyzed to determine the delta13CVPDB of the volatile components common to strawberry. The delta13CVPDB values are allowed to differentiate between different biogenetic pathways (C3 and CAM plants) and more interestingly between plants of the same CO2 fixation group (C3 plants). Additional analyses were performed on all the samples by means of Enantioselective Gas Chromatography (Es-GC), measuring the enantiomeric distribution of linalool and gamma-decalactone. It was found that GC-C-IRMS and Es-GC measurements were in agreement to detect the presence of non-natural strawberry aromas in the food matrices studied.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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In this paper, the rapid liquefaction of a corncob was achieved by plasma electrolysis, providing a new method for cellulosic biomass liquefaction. The liquefaction rate of the corncob was 95% after 5 min with polyethylene glycol and glycerol as the liquefying agent. The experiments not only showed that H+ ions catalyzed the liquefaction of the corncob, but also that using accelerated H+ ions, which were accelerated by an electric field, could effectively improve the liquefaction efficiency. There was an obvious discharge phenomenon, in which the generated radicals efficiently heated the solution and liquefied the biomass, in the process of plasma electrolytic liquefaction. Finally, the optimum parameters of the corncob liquefaction were obtained by experimentation, and the liquefaction products were analyzed.

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Tetrahydrofuran – Wikipedia,
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A three-step supercritical CO2 extraction was used for selective fractionation of fast pyrolysis bio-oil. Oxygen-containing compounds in bio-oil and its fractions were characterized using infrared spectroscopy (IR), 1H nuclear magnetic resonance spectroscopy (NMR), gas chromatography-mass spectrometry (GC-MS) and negative-ion electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). With appropriate optimization of extraction parameters, lipids, hemicellulose, lignin and condensed aromatics were found enriched in three different fractions. The molecular composition and compound classes were identified by combined analytical techniques, and the selectivity of the fractionation was proved. The compound-type-specific fractionation also facilitated the following characterization and provided insights into the chemical composition of bio-oil. Results indicated that CO2 supercritical fluid extraction was potential for bio-oil preprocessing.

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Tetrahydrofuran – Wikipedia,
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A practical, efficient and general method was developed for the deprotection of a variety of aromatic and aliphatic acetals to their corresponding catechol or diol derivatives using thiol immobilized on silica gel. This is an application for the well-known commercial solid-supported thiol (SiliaMetS Thiol). The procedure is mild and amenable to scale-up. It does not require inert atmosphere and clean conversions were observed. This method is applicable to substituted 1,3-benzodioxole and aliphatic acetals with different functionalities. It offers the advantage of a general route with high yield, which can be undertaken at ambient temperature.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Catalytic fast pyrolysis (CFP) is an attractive approach to convert biomass to high-quality bio-oil through the deoxygenation of pyrolysis vapors in the form of H2O, CO, and CO2. However, the deoxygenation process comes at the expense of bio-oil yield. This review begins with recent progress on lignocellulosic biomass pyrolysis chemistry and techniques, and then focuses on the latest improvements to the design of advanced catalysts and novel CFP processes. It was found that basic metal oxides (e.g., MgO and CaO) are promising alternative catalysts to zeolites (such as ZSM-5) with respect to the preferred decarboxylation reaction, which merits additional investigation on their structure-function relationships in the future. Additionally, catalytic co-pyrolysis of biomass with waste plastics or waste tires over zeolites is an attractive approach from the viewpoint of preferred dehydration reactions and the high-value utilization of solid wastes. However, the physicochemical properties of the catalysts should be further adjusted. Furthermore, in spite of many interesting results reported in the literature, quantitatively analysis and uniform data presentation format is necessary for the further development of CFP techniques.

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Reference:
Tetrahydrofuran – Wikipedia,
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Sodium nitroprusside under mildly basic conditions has been found to effect the conversion of nitrogen to oxygen at saturated carbon centers.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem