Category: 63095-51-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

63095-51-2, (R)-4-propyl-dihydrofuran-2-one 10.0 g (78.1 mmol)Dissolved in 100 mL DMF, followed by the addition of potassium carbonate 11.9 g (85.9 mmol).(S)-2-aminobutyric acid 8.9 g (86.4 mmol), warmed to 50 C,Stir the reaction for 15h, the temperature of the reaction solution dropped to 0-5 C, diluted with water,Adjust the pH to 3 with 2N hydrochloric acid solution and extract three times with dichloromethane.The organic phases were combined, dried and concentrated to give 16.2 g of Intermediate II.The yield was 90.0%.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Beijing Wanquan De Zhong Pharmaceutical Biological Co., Ltd.; Ma Xiang; Zhao Guolei; Zhao Yunping; (7 pag.)CN108947883; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

63095-51-2, To a 250 ml three-necked flask with mechanical stirring function was added compound I (12.8 g, 99.9 mmol), L-2-aminobutyramide (20.4 g, 20.0 mmol), and ethanol (50 ml). Stir at reflux for 24h. The reaction solution was concentrated, purification by column chromatography gave the compound.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Fujian Haixi New Drug Initiative Co., Ltd.; Kang Xinshan; Wang Ruyong; Ye Yizhang; Gong Xuan; Zhang Fengsen; Wang Zhonghong; Li Dandan; Fu Yueli; Feng Yan; (35 pag.)CN110357790; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

A solution of thionyl chloride (200 mL) anhydrous ZnCI2 (10.6 g, 0.078 mol), and the compound of formula I (bOg, 0.78mmol) was heated to 85 C. After the reaction was complete, the solvents were evaporated in vacuo. The crude product was purified by vacuum distillation to obtain the title compound X as a yellow oil. Yield 79.7%.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; WANG, Peng; LI, Pixu; WEI, Qiang; LIU, Yuanhua; (61 pag.)WO2016/191435; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2,63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add phenol (18.8g, 200.0mmol) and tetraisopropyl titanate (2.8g, 10.0mmol) to a 500ml three-necked bottle with stirring function, aan additional 250 ml of toluene was added and the mixture was stirred at reflux for 1 h. The solvent was evaporated under reduced pressure. Toluene (200 ml) and compound (R)-4-propyldihydrofuran-2-one (12.8 g, 10.0 mmol) were added to the reaction system, and the reaction was refluxed for 36 h. Reduce the reaction system to room temperature, add 2M dilute hydrochloric acid to adjust the pH to 5-6, the layers were separated and the organic phase was washed with water. Rotary evaporation to remove toluene, purification by column chromatography gave the compound (R)-3-hydroxymethylhexanoic acid phenyl ester.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Fujian Haixi New Drug Initiative Co., Ltd.; Kang Xinshan; Wang Ruyong; Ye Yizhang; Gong Xuan; Zhang Fengsen; Wang Zhonghong; Li Dandan; Fu Yueli; Feng Yan; (35 pag.)CN110357790; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

63095-51-2, Under the protection of nitrogen, brivaracetam intermediate III (128.1g, 1 mol) was dissolved in 1L in methylene chloride. Lower the temperature to 0 C. Add trimethylsilyl iodide (150 ml). The reaction solution at 20-30 C was stirred for 2 hours. Followed by adding hydrochloric acid solution (1M, 800 ml) and sodium thiosulfate aqueous solution (mass percentage of 10%, the quality percent means that the quality of the sodium thiosulfate with the percentage of the total mass of the aqueous solution of sodium thiosulfate, 400 ml. ), The aqueous phase is 1L dichloromethane extraction, the organic phase with saturated salt water washing twice, dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to obtain brivaracetam intermediate IV (254.6g), yield 99.5%, purity: 95.6% (GC).

63095-51-2 (R)-4-Propyldihydrofuran-2(3H)-one 10997054, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588741; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,willBuvacizine Intermediate III(128.1 g, 1 mol) was dissolved in 1 L of dichloromethane,Cooling to 0 ,Was added trimethylsilyl iodide (150mL),The reaction solution was stirred at 20 to 30 C for 2 hours.Followed by the addition of hydrochloric acid solution (1 M, 800 mL) and aqueous sodium thiosulfate solution (10% by mass) as the percentage of sodium thiosulfate and the total mass of sodium thiosulfate aqueous solution, 400 mL. ,The aqueous phase was extracted with 1 L of dichloromethane,The organic phase was washed twice with saturated brine,Dried over anhydrous sodium sulfate,filter,Concentration under reduced pressure gave hexanoic acid derivative IV (254.6 g, 99.5%),Yield 99.5%Purity: 95.6% (GC)., 63095-51-2

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588740; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2,63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1) Compound 4 (10 g, 78.13 mmol) was dissolved in toluene.A mixed solution of thionyl chloride (11.9 g, 100 mmol) and hydrobromic acid (8.1 g, 100 mmol) was added.Stir at room temperature for 8 h, EtOAc evaporatedThat is, compound 5.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Lizhu Group Xin Beijiang River Pharmaceutical Co., Ltd.; Wang Longshu; Lu Zengjie; Jiang Qiao; Chen Guo; Li Chengbo; Chen Yuechang; (14 pag.)CN109134406; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2,63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add a compound (R)-4-propyldihydrofuran-2-one (12.8g, 100.0mmol) and SOCl2 (12.8ml) to a 250mL three-neck flask with a mechanical stirring function, anhydrous zinc chloride (1.36 g, 10.0 mmol) was added, and the mixture was heated to 80 C and stirred for 15 h. The reaction solution was cooled in an ice bath, then cyclohexanol (50 mL) was added dropwise, and stirring was continued for 3 h. Stop the reaction and remove most of the volatiles under reduced pressure. The residue was separated by column chromatography to obtain the target compound.

63095-51-2 (R)-4-Propyldihydrofuran-2(3H)-one 10997054, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Fujian Haixi New Drug Initiative Co., Ltd.; Kang Xinshan; Wang Ruyong; Ye Yizhang; Gong Xuan; Zhang Fengsen; Wang Zhonghong; Li Dandan; Fu Yueli; Feng Yan; (35 pag.)CN110357790; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem