Category: 550-33-4

Method for reducing primer dimer formation and increasing amplification efficiency was written by Lee, Young Jo; Kim, Dae Young. And the patent was published on July 5,2018.Reference of 550-33-4 The following contents are mentioned in the patent:

The present invention relates to a method for amplifying at least three target nucleic acid mols. with reduced primer dimer formation in a multiplex amplification reaction. The method of present invention can inhibit primer dimer formation and hence generation of nonspecific amplification products in an effective manner in a multiplex amplification reaction for at least three target nucleic acid mols. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Reference of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Reference of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Post chemical mechanical polishing formulations and method of use was written by Liu, Jun; Barnes, Jeffrey A.; Zhang, Peng; Sun, Laisheng; Medd, Steven. And the patent was published on August 6,2015.Computed Properties of C10H12N4O4   The following contents are mentioned in the patent:

A cleaning composition and process for cleaning post-chem. mech. polishing (CMP) residue and contaminants from a microelectronic device having said residue and contaminants thereon. The cleaning compositions are substantially devoid of amines and ammonium-containing salts. The composition achieves highly efficacious cleaning of the post-CMP residue and contaminant material from the surface of the microelectronic device without compromising the low-k dielec. material or the copper interconnect material. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Computed Properties of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Computed Properties of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Improving the biological activity of siRNA through modulation of its thermodynamic profile was written by Maier, Martin; Addepalli, Haripriya; Zhang, Ligang; Peng, Paul; Manoharan, Muthiah; Bettencourt, Brian; Hinkle, Greg. And the patent was published on September 9,2011.Related Products of 550-33-4 The following contents are mentioned in the patent:

The present invention describes the combination of thermally stabilizing and destabilizing chem. modifications and sequence alterations incorporated in specific regions of the duplex to optimize the thermodn. profile of a given siRNA duplex and to further improve its silencing activity. The average internal stability profile of highly active siRNAs is highly specific and clearly distinguishable from non-functional ones. With large numbers of possible siRNAs against a given target, it is generally possible to identify potent siRNAs with a close-to-optimal thermodn. profile. However in many cases, the number of possible siRNAs against a given target RNA is limited due to short target RNA sequence or poor sequence homol. across species (for cross-reactive siRNAs). In these cases, modulating the thermal stability of the duplex by selectively placing thermally stabilizing and/or destabilizing modifications could be particularly useful to generate active siRNAs. The choice of modification and their position will depend on the thermodn. profile of the siRNA to be modified. Thermally destabilizing chem. modifications such as abasic residues, universal bases with reduced or abolished capability to form hydrogen bonds with opposing bases (e.g. 2,4-difluorotoluyl, 5-nitroindole), or unlocked nucleic acids in the low thermal stability region of the duplex (e.g., region around the cleavage site or within the 5′-half of the antisense strand), or the placement of one or more mismatches in this low thermal stability region or both, in addition to chem. modifications, such as locked nucleic acid or 2′-modified RNA, to further stabilize the high thermal stability region at or near the 3′-end of the antisense strand will improve the potency of siRNA, including the silencing activity of siRNA. Thus, IC50 values are derived using results from HeLa cell-based PTEN assay is siRNAs targeting firefly luciferase. The results confirm that local destabilization of the central region of the sense strand with mismatch base pairings or modified nucleobases can lead to substantial potency enhancements. For this particular sequence, mismatched base pairings or introduction of 2,4-difluorotoluyl ribonucleotide in positions 9 and 10 were found to significantly enhance potency over the parent unmodified compound This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Related Products of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Copper cleaning and protection formulations was written by Koji, Yukichi; Hirashima, Ryoichi; Saito, Hideaki. And the patent was published on September 19,2013.Category: tetrahydrofurans The following contents are mentioned in the patent:

A cleaning composition for cleaning post-chem. mech. polishing residue and contaminants from a microelectronic device without compromising the low-k dielec. material or the copper interconnect material comprises at least one solvent, at least one corrosion inhibitor, at least one polyamine species, and at least one quaternary base, wherein the at least one polyamine species is at least one of an aliphatic polyamine or a cyclic polyamine. A composition for cleaning copper wire semiconductors (removing benzotriazole residue) comprises 0.7 weight% triethanolamine, 0.03 weight% gallic acid, 0.16 weight% tetramethylammonium hydroxide and 99.1 weight% water. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Category: tetrahydrofurans).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Microneedle compositions and methods of delivery using the same was written by Artzi, Natalie; Dosta, Pere; Puigmal, Nuria. And the patent was published on September 1,2022.SDS of cas: 550-33-4 The following contents are mentioned in the patent:

The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4SDS of cas: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.SDS of cas: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Methods for preparing and using tagged nucleotide compositions for nanopore based sequencing was written by Fuller, Carl W.; Kumar, Shiv; Ju, Jingyue; Davis, Randall; Chen, Roger. And the patent was published on October 1,2015.Formula: C10H12N4O4   The following contents are mentioned in the patent:

This disclosure provides systems and methods for attaching nano pore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides. Provided herein are nucleotides with attached tags and methods for attaching tags to nucleotides. The tags can be attached by chem. reactions, such as click chem. In an aspect, the present disclosure provides a tagged nucleotide, comprising a poly-phosphate moiety having a terminal phosphate and a tag covalently coupled to the terminal phosphate of the nucleotide by a triazole, a 1,2-diazine, a disulfide, a secondary amine, a hydrazone, a thio-acetamide, or a maleimide-thioadduct. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Formula: C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Formula: C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemically modified guide RNAs for genome editing with Cas12b was written by Rajeev, Kallanthottathil G.; Chadwick, Alexandra; Reiss, Caroline. And the patent was published on October 14,2021.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:

Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations thereto. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemically modified guide RNAs for genome editing with Cas9 was written by Chadwick, Alexandra; Rajeev, Kallanthottathil G.; Rohde, Ellen; Cheng, Christopher; Reiss, Caroline. And the patent was published on October 14,2021.Product Details of 550-33-4 The following contents are mentioned in the patent:

Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing PCSK9 and ANGPTL3 gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Product Details of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Enhancement of siRNA silencing activity using universal bases or mismatches in the sense strand was written by Maier, Martin; Addepalli, Haripriya; Manoharan, Muthiah. And the patent was published on January 28,2010.HPLC of Formula: 550-33-4 The following contents are mentioned in the patent:

Double-stranded nucleic acids useful as an siRNAs are provided that have a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified or non-natural nucleobases, or one or more mismatch base pairings with the antisense strand. A method of gene silencing comprises administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases or one or more mismatch base pairings with the antisense strand. The effect of mismatch base pairing and modified nucleobases on siRNA potency is dependent on the mismatched base pair and its position on the sense strand. Apparently, local destabilization in the central region of the sense strand via mismatched base pairs (position 9-12) are more effective in enhancing potency than those outside of this region. The effect of modified nucleobases (e.g., 2,4-difluorotoluyl-ribonucleotide and -deoxyribonucleotide, 5-nitroindole deoxyribonucleotide and ribonucleotide, deoxyribo- and ribonebularine,, deoxy- and riboinosine, and ribo- or deoxyribo-2-aminopurine) to enhance potency over the parent compound is particularly significant in position 10. While there is no significant correlation between activity and thermal stability at positions 9, 11, and 12, the potency of the siRNAs appears to increase with decreased thermal stability due to modifications in position 10. Further, abasic modifications in position 10 and 12 particularly enhance potency over the parent compound This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4HPLC of Formula: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Anti-inflammatory and anti-allergy extracts from nettle was written by Alberte, Randall S.; Roschek, William P., Jr.; Li, Dan. And the patent was published on January 14,2010.Electric Literature of C10H12N4O4   The following contents are mentioned in the patent:

The present invention relates in part to nettle extracts comprising at least one compound useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions. The nettle extracts showed inhibitory activities against COX-1, COX-2, 5-lipoxygenase, and tryptase, as well as H1 antagonistic activity. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Electric Literature of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem