Category: 5455-94-7

Nazarski, Ryszard B. published the artcile< Physical image vs structure relation: part 12 - structure of 2,2,5,5-tetramethyl-dihydro-furan-3-one oxime and its protonated forms through isomerization and NMR spectra>, Product Details of C8H14O2, the main research area is structure methyldihydrofuranone oxime protonated form thermal isomerization NMR GIAO.

The study of an isomeric A/B mixture of the title oxime 1, by photolytic or thermal E,Z-isomerization and NMR measurement including 1H{1H}-NOE difference spectra, led to assignment of the E configuration to its predominating form A. The 1H/13C data were interpreted in terms of steric overcrowding of both forms, especially of the thermolabile photoproduct B. Four classical (empirical) NMR methods of elucidating the oxime geometry were critically tested on these results. Unexpected vapor-phase photoconversion A→B in the window glass-filtered solar UV and spectroscopic findings on their protonated states were discussed, as well. The kinetically controlled formation of the N-protonated species (Z)-5+ was proved exptl. In addition, some 1H NMR assignments reported for structurally similar systems were rationalized (3 and 4) or revised (1 and 7-9) with the GIAO-DFT(B3LYP) and/or GIAO-HF calculational results.

Journal of Physical Organic Chemistry published new progress about Cis-trans thermal isomerization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Netto-Ferreira, J. C.; Wintgens, V.; Scaiano, J. C. published the artcile< Lifetimes of biradicals produced in the Norrish Type I reaction of methyl-substituted 2-tetralones>, Synthetic Route of 5455-94-7, the main research area is Norrish photolysis biradical lifetime tetralone.

The Norrish Type I biradicals derived from 2-tetralones decay by a competition of recyclization to the starting material, intramol. disproportionation to yield aldehydes and decarbonylation. The last path is only favored in the case of 3,3-dimethylated derivatives while, in the other extreme, the parent 2-tetralone is essentially photostable. The biradical lifetimes are around 140 ns in benzene and 40 ns or less in nonaromatic solvents; they show little sensitivity to the solvent polarity and hydrogen bonding ability. The remarkable stabilization of the biradical in benzene is probably due to specific interactions between the acyl center in the biradical and benzene, since similar effects have not been observed in other biradicals.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Biradicals Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Synthetic Route of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wappes, Ethan A.; Vanitcha, Avassaya; Nagib, David A. published the artcile< β C-H di-halogenation via iterative hydrogen atom transfer>, SDS of cas: 5455-94-7, the main research area is geminal dihalide regioselective preparation; imidate preparation photochem tandem dihalogenation hydrogen transfer.

A radical relay strategy for mono- and di-halogenation (iodination, bromination, and chlorination) of sp3 C-H bonds was developed. This is the first example of β C-H di-halogenation is achieved through sequential C-H abstraction by iterative, hydrogen atom transfer (HAT). A double C-H functionalization was enabled by in-situ generated imidate radicals, which facilitate selective N to C radical translocation and tunable C-X termination. The versatile, geminal di-iodide products were further elaborated to β ketones and vinyl iodides. Mechanistic experiments explained the unique di-functionalization selectivity of this iterative HAT pathway, wherein the second C-H iodination is twice as fast as the first.

Chemical Science published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, SDS of cas: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bennett, Gregory B.; Houlihan, William J.; Mason, Robert B.; Engstrom, Robert G. published the artcile< Synthesis and biological evaluation of substituted 2,2'-oxybis(propionic acid) derivatives and related compounds>, Application In Synthesis of 5455-94-7, the main research area is hypolipidemic oxybispropionic acid derivative; propionic acid derivative hypolipidemic; furan derivative hypolipidemic.

A series of 2,2′-oxybis(propionic acid) derivatives, cyclic imides, and other analogs was prepared and hypolipidemic activity measured. The lipid-lowering activity of various 2,2,5,5-tetrasubstituted furan derivatives was also measured. No significant hypolipidemic activity was observed Structure-activity relationships are discussed.

Journal of Medicinal Chemistry published new progress about Lipids Role: BIOL (Biological Study). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Application In Synthesis of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harrison, Carrie-Ann; Jackson, P. Mark; Moody, Christopher J.; Williams, Jonathan M. J. published the artcile< Cyclopenta[b]indoles. Part 2. Model studies towards the tremorgenic mycotoxins>, Product Details of C8H14O2, the main research area is cyclopentaindole; tremorgenic mycotoxin cyclopentindole.

The 7-bromocyclopenta[b]indole I has been converted into the hydroxybutenyl derivatives and a tetrahydrofuranylidene derivative in model studies towards the elaboration of paspalitrem and lolitrem type side chains. In a parallel approach, the cyclopentapyrrole II was converted into the fused α-pyrone III which acted as a pyrrole-2,3-quinodimethane, and underwent Diels-Alder reaction to give, after loss of carbon dioxide, the cyclopentaindoles, e.g. IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistrypublished new progress about Indole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rodina, Liudmila L.; Galkina, Olesia S.; Maas, Gerhard; Platz, Matthew S.; Nikolaev, Valerij A. published the artcile< A New Method for C-H Functionalization of Aliphatic Compounds by an Unusual Photochemical Reaction of Diazoketones without Elimination of Nitrogen>, Reference of 5455-94-7, the main research area is diazotetrahydrofuranone aliphatic compound Wolff rearrangement photochem; hydrazone diazotetrahydrofuranyl preparation; aliphatic compound diazotetrahydrofuranone Wolff rearrangement photochem; bisfuranylhydrazonoethane preparation.

Benzophenone-sensitized reactions of 4-diazotetrahydrofuran-3(2H)-ones with H-donors such as THF, 1,4-dioxane, cyclohexane and di-Et ether, occur without elimination of nitrogen and give rise to the corresponding N-substituted hydrazones or bis-hydrazonoethanes due to a formal insertion of the terminal N atom of diazo group into α-C-H bonds of ethers and aliphatic hydrocarbons, with yields of up to 78 %. Long-wavelength UV irradiation (λ>310 nm) was most suitable for this process, whereas oxygen mols. adequately quench the triplet excited state of the diazoketone and reduce the preparative yields of C-H-insertion products. Hence this photochem. reaction of diazoketones could be used for C-H functionalization of different aliphatic compounds

Asian Journal of Organic Chemistrypublished new progress about Aliphatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Lin; Badea, Beth Ann; Enyeart, Debra; Berger, Elaine M.; Mais, Dale E.; Boehm, Marcus F. published the artcile< Synthesis of isotopically labeled 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective Ligand>, Electric Literature of 5455-94-7, the main research area is isotopically labeled retinoid preparation binding receptor; benzoic acid naphthylethenyl preparation binding receptor; naphthylethenylbenzoic acid preparation binding receptor.

LGD1069, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid, is the first retinoid X receptor (RXR)-selective retinoid to enter clin. trials for treatment of dermatol. diseases and cancer. In order to exam. biol. properties such as receptor binding, metabolism and bioavailability, [13C]-, [14C]-, and [3H]-labeled LGD1069 is required. Herein, the authors describe synthetic methods for preparing isotopically labeled homologs of LGD1069 and [3H]-9-cis-retinoic acid with RXR active retinoids. The final radiolabeled products, [6,7-3H]-LGD1069 and 3-[14C]-LGD1069 have specific activities of 56 Ci/mmol and 49 mCi/mmol, resp. Radiochem. purities are 99.5% for [6,7-3H]-LGD1069 and 99.0% for 3-[14C]-LGD1069. The chem. purity is 99.0% for 3-[13CD3]-LGD1069. Competition binding studies with known retinoids show similar Kd values when either [6,7-32H]-LGD1069 or [3H]-9-cis-retinoic acid as the radioligand.

Journal of Labelled Compounds & Radiopharmaceuticalspublished new progress about Receptors Role: BSU (Biological Study, Unclassified), BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Electric Literature of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lauer, Matthew G.; Henderson, William H.; Awad, Amneh; Stambuli, James P. published the artcile< Palladium-Catalyzed Reactions of Enol Ethers: Access to Enals, Furans, and Dihydrofurans>, Name: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is palladium catalyzed oxidation alkyl enol ether enal furan hydrofuran.

The palladium-catalyzed oxidation of alkyl enol ethers to enals, which employs low loadings of a palladium catalyst, is described. The mild oxidation conditions tolerate a diverse array of functional groups, while allowing the formation of di-, tri-, and tetrasubstituted olefins. The application of this methodol. to intramol. reactions of alkyl enol ethers containing pendant alcs. provides furan and 2,5-dihydrofuran products.

Organic Letterspublished new progress about Acetalization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Name: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. Quality Control of 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one

LGD1069, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl] benzoic acid, is the first retinoid X receptor (RXR) selective retinoid to enter clinical trials for treatment of dermatological diseases and cancer. In order to examine biological properties such as receptor binding, metabolism and bioavailability, [13C]-, [14C]-, and [3H]-labeled LGD1069 is required. Herein, we describe synthetic methods for preparing isotopically labeled homologs of LGD 1069 as well as comparative competition binding data for [6,7-3H]-LGD1069 and [3H]-9-cis retinoic acid with RXR active retinoids. The final radiolabeled products, [6,7-3H]-LGD1069 and 3-[14C]-LGD1069 have specific activities of 56 Ci/mmol and 49 mCi/mmol, respectively. Radiochemical purities are 99.5% for [6,7-3H]-LGD1069 and 99.0% for 3-[14C]-LGD1069. The chemical purity is 99.0% for 3-[13CD3]-LGD1069. Competition binding studies with known retinoids show similar K(d) values when either [6,7-3H]-LGD1069 or [3H]-9-cis retinoic acid is used as the radioligand.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 5455-94-7 is helpful to your research. Quality Control of 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 5455-94-7, Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment.

The present invention relates to a compound of formula (I) wherein: R1 is C1-C3alkoxy, C1-C2alkoxy-C1-C3alkoxy, C1-C2fluoroalkoxy, ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl; R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, C1-C3alkoxy, C1-C3fluoroalkyl, C1-C2fluoroalkoxy, C1-C2alkoxy-C1-C3alkoxy-, or C1fluoroalkoxy-C1-C3alkoxy-; provided that when R1 is ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl, then R2 is hydrogen, ethyl, n-propyl, cyclopropyl, vinyl or ethynyl; and Y is O, S, S(O), S(O)2, N(C1-C2alkyl), N(C1-C2alkoxy), C(O), CR8R9 or -CR10R11CR12R13-; and and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem