Category: 52079-23-9

52079-23-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9

Homochiral 2,4-Disubstituted 1,3-Dioxanes from (S)-(-)-Malic Acid: Stereoselective Synthesis and Investigation of the NMDA Receptor Affinity of All Four Stereoisomers

Starting from a single enantiomerically pure compound, (S)-(-)-malic acid, all four stereoisomeric 4-dimethylaminomethyl-2-phenyl-1,3-dioxanes (S,S)-15, (R,R)-15 (S,R)-16, and (R,S)-16 are prepared: Transacetalisation of benzaldehyde dimethyl acetal (6b) with (S)-(-)-methyl 2,4-dihydroxybutyrate (7a), which is obtained by chemoselective BH3 reduction of (S)-(-)-malic acid monoester 8b, yields the diastereomeric 1,3-dioxane derivatives (S,S)-10 and (R,S)-11 in a 85:15 ratio.LDA deprotonation of (S,S)-10 followed by protonation leads to C-4 epimerisation <(S,S)-10:(S,R)-11 = 30;70>.The thermodynamically controlled 88:12 equilibrium of (R,R)-10 and (S,R)-11 is reached by treatment of (S,R)-11 with acid.Aminolysis with dimethylamine and subsequent LiAlH4 reduction transform the four stereoisomeric esters (S,S)-10, (R,R)-10, (S,R)-11 and (R,S)-11 to give the amines (S,S)-15, (R,R)-15, (S,R)-16 and (R,S)-16, respectively.In the 3H-(+)-MK 801 displacement experiment (S,S)-15, (R,R)-15, (S,R)-16 and (R,S)-16 show a very little affinity to the phencyclidine binding site in the cation channel associated with the NMDA receptor. – Key Words: Butyric acid derivatives, (S)-(-)-24-dihydroxy-/ 1,3-Dioxanes/ NMDA antagonists, noncompetitive

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 52079-23-9 is helpful to your research. 52079-23-9

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 52079-23-9, Name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, molecular formula is C4H6O3. In a Article, authors is Mori, Kenji£¬once mentioned of 52079-23-9

SYNTHESIS OF THE OPTICALLY ACTIVE FORMS OF 4,10-DIHYDROXY-1,7-DIOXASPIRO<5.5>UNDECANE AND THEIR CONVERSION TO THE ENANTIOMERS OF 1,7-DIOXASPIRO<5.5>UNDECANE, THE OLIVE FLY PHEROMONE

Both the enantiomers of 1,7-dioxaspiro<5.5>undecane, the major component of the pheromone of the olive fly (Dacus oleae), were synthesized from (S)-malic acid.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 52079-23-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 52079-23-9, in my other articles.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 52079-23-9, molcular formula is C4H6O3, introducing its new discovery. 52079-23-9

EPOTHILONE DERIVATIVES, METHOD FOR PRODUCING SAME AND THEIR PHARMACEUTICAL USE

This invention relates to the new epothilone derivatives of general formula I, 1in which substituents Y, Z R2a, R2b, R3, R4a, R4b, D?E, R5, R6, R7, R8 and X have the meanings that are indicated in more detail in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanomas, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (psoriasis, arthritis). To avoid uncontrolled proliferation of cells and for better compatibility of medical implants, they can be applied or introduced into polymer materials. The compounds according to the invention can be used alone or to achieve additive or synergistic actions in combination with other principles and classes of substances that can be used in tumor therapy.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 52079-23-9, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 52079-23-9

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52079-23-9

To a suspension of NaH (60% in mineral oil, 552 mg, 12.0 mmol) in THF (5 mL) was added a solution of (S)-3-hydroxydihydrofuran-2(3H)-one (46a, 1.02 g, 10.0 mmol) in TetaF (5 mL) slowly drop wise at 0 0C under N2 atmosphere. The reaction mixture was stirred for 30 minutes and dimethylsulphate (1.4 mL, 15.0 mmol) was added. The reaction mixture was stirred at r.t. overnight and the TLC shows completion of the reaction. Cold water (25 mL) was added to the reaction mixture and extracted with ethyl acetate. Organic layer washed with brine, dried over anhydrous Na2SO4 and filtered. Concentrated to provide (S)-3-hydroxydihydrofuran-2(3H)- one (46a) as yellow oil, which was dissolved in MeOH. Catalytic amount of K2CO3 (50 mg) was added at 0 0C and the reaction mixture stirred for Ih. TLC shows completion of the reaction. Cold water (25 mL) was added to the reaction mixture and extracted with ethyl acetate. Organic layer washed with brine, dried over anhydrous Na2SO4 and filtered. Concentrated to provide (S)- methyl 4-hydroxy-2-methoxybutanoate (46b, 1.5g, 99%) as yellow oil. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 2.07 – 2.28 (m, 1 H) 2.36 – 2.58 (m, 1 H) 3.36 (s, 3 H) 3.49 (s, 3 H) 3.85 – 4.07 (m, 1 H) 4.29 – 4.42 (m, 2 H).

52079-23-9 (S)-(-)-alpha-Hydroxy-gamma-butyrolactone 357853, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/97578; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52079-23-9,(S)-(-)-alpha-Hydroxy-gamma-butyrolactone,as a common compound, the synthetic route is as follows.,52079-23-9

5- (2-aminoethoxy)-N- [3-chloro-4- (pyridin-2-ylmethoxy) phenyl] quinazolin-4-amine (obtained as described in Example 2.6, preparation of starting materials, 0.5 g, 1.19 mmol) was heated to 130C in xylene (20 ml) until it had dissolved. (S)- (-)-a-hydroxy-y- butyrolactone (0.10 ml, 1.31 mmol) was added and the mixture was stirred at 130C for 3 hours. More (S)-(-)-oc-hydroxy-y-butyrolactone (0.05 ml, 0.66 mmol) was added and the mixture was heated for a further 2 hours. The resultant precipitate was filtered off while the mixture was hot, washed with diethyl ether (3 x 10 ml) and dried to give the title compound as a solid (430 mg, 69%) ; NMR spectrum (DMSO-d6) 1.38-1. 55 (m, 1H), 1.69-1. 85 (m, 1H), 3.37-3. 50 (m, 2H), 3.61-3. 77 (m, 2H), 3.89-4. 00 (m, 1H), 4. 28-4. 45 (m, 3H), 5.29 (s, 2H), 5.51 (d, 1H), 7.13 (d, 1H), 7.22 (d, 1H), 7.28-7. 41 (m, 2H), 7.49-7. 62 (m, 2H), 7.71 (t, 1H), 8.01 (d, 1H), 8.14-8. 25 (m, 1H), 8.45 (s, 1H), 8. 59 (d, 1H), 9. 82 (s, 1H) ; Mass spectrum MU 523.9

As the paragraph descriping shows that 52079-23-9 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/51923; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52079-23-9, Example 2 Synthesis of (R)-2-{3-[N-(benzoxazole-2-yl)-N-(3-(4-methoxyphenoxy)propyl)aminomethyl]phenyloxy}butyrolactone (Compound (3)) In an argon atmosphere, N-(benzoxazole-2-yl)-N-(3-(4-methoxyphenoxy)propyl)-3-hydroxybenzylamine (2.0 g), (S)-2-hydroxybutyrolactone (1.0 g), and triphenylphosphine (2.6 g) were dissolved in toluene (30 mL), and a solution of di-tert-butyl azodicarboxylate (2.3 g) in toluene (10 mL) was dropwise to the solution at 0C, followed by stirring for 24 hours at 40C. Subsequently, triphenylphosphine (1.3 g) and di-tert-butyl azodicarboxylate (1.1 g) were added to the mixture at 40C, followed by stirring for 24 hours at the same temperature. The reaction mixture was returned to room temperature. Water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine. The washed mixture was dried over sodium sulfate anhydrate. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified through silica gel column chromatography (n-hexane/ethyl acetate = 1/1), to thereby yield a colorless oil (2.2 g, 92%, 98% ee). Optical purity: Measurement conditions: HPLC Column: CHIRALPAK AS Column temperature: 35C Solvent: n-hexane/EtOH = 60/40 Flow rate: 1 mL/min Retention time: 9.37 min (S-form; 6.86 min) 1H-NMR(400MHz, CDCl3) delta ppm: 2.14(quintet, J=7Hz, 2H), 2.36-2.44(m, 1H), 2.60-2.67(m, 1H), 3.71(t, J=7Hz, 2H), 3.76(s, 3H), 3.96(t, J=6Hz, 2H), 4.25-4.31(m, 1H), 4.43-4.49(m, 1H), 4.77(s, 2H), 4.89(t, J=8Hz, 1H), 6.81(s, 4H), 6.95-7.03(m, 4H), 7.17(t, J=8Hz, 1H), 7.22-7.28(m, 2H),7.37(d, J=8Hz, 1H). Example 6; Chemical yield and optical purity; Tables 1 and 2 show chemical yield and optical purity of Compound (3x) produced through the process of the present invention (Nos. 1 and 2 in Table 1), of Compound (3x) produced from sulfonate derivatives of optically active 2-hydroxybutyrolactone (Nos. 3 to 8 in Table 1), and of Compounds (5y) and (6y) produced through a process disclosed in Patent Document 1 (Table 2). As is clear from Tables 1 and 2, the process of the present invention (Nos. 1 and 2 in Table 1) is remarkably excellent in the production of an optically active butyric acid compound and a production intermediate therefor at high yield and high purity.

As the paragraph descriping shows that 52079-23-9 is playing an increasingly important role.

Reference£º
Patent; Kowa Co., Ltd.; EP1887005; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonic acid 2-oxo-tetrahydro-furan-3S-yl ester Methanesulfonyl chloride (1.67 ml, 21.56 mmol) was added to a stirred solution of (S)-3-hydroxy-2-oxo-tetrahydrofuran (2 g, 19.6 mmol), 4-N,N-dimethylaminopyridine (240 mg, 1.96 mmol) and diisopropylethylamine (3.76 ml, 21.56 mmol) in dry dichloromethane (20 ml), under nitrogen, at -40 C. The mixture was stirred for 30 minutes and then allowed to warm up to room temperature, then it was washed with 2M hydrochloric acid solution (50 ml), dried and evaporated to a solid. The crude product was purified by flash chromatography on silica gel, eluding with ethyl acetate-cyclohexane (1:1). Trituration with diethylether and drying in vacuo afforded the title compound as a crystalline white solid (2.23 g, 63%): mp. 70-75 C.; NMR delta (CDCl3) 5.33 (1H, t, J 8 Hz), 4.53 (1H, dt, J 9 and 2 Hz), 4.34 (1H, dt, J 10 and 6 Hz), 3.28 (3H, s), 2.86-2.72 (1H, m), 2.65-2.47 (1H, m)., 52079-23-9

The synthetic route of 52079-23-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Glaxo Wellcome Inc.; US6197761; (2001); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (2-aminoethoxy)-N- [3-chloro-4- (pyridin-2-ylmethoxy) phenyl] quinazolin-4-amine (obtained as described in Example 2.6, preparation of starting materials, 0.5 g, 1.19 mmol) was heated to 130C in xylene (20 ml) until it had dissolved. (S)- (-)-a-hydroxy-y- butyrolactone (0.10 ml, 1.31 mmol) was added and the mixture was stirred at 130C for 3 hours. More (S)-(-)-oc-hydroxy-y-butyrolactone (0.05 ml, 0.66 mmol) was added and the mixture was heated for a further 2 hours. The resultant precipitate was filtered off while the mixture was hot, washed with diethyl ether (3 x 10 ml) and dried to give the title compound as a solid (430 mg, 69%) ; NMR spectrum (DMSO-d6) 1.38-1. 55 (m, 1H), 1.69-1. 85 (m, 1H), 3.37-3. 50 (m, 2H), 3.61-3. 77 (m, 2H), 3.89-4. 00 (m, 1H), 4. 28-4. 45 (m, 3H), 5.29 (s, 2H), 5.51 (d, 1H), 7.13 (d, 1H), 7.22 (d, 1H), 7.28-7. 41 (m, 2H), 7.49-7. 62 (m, 2H), 7.71 (t, 1H), 8.01 (d, 1H), 8.14-8. 25 (m, 1H), 8.45 (s, 1H), 8. 59 (d, 1H), 9. 82 (s, 1H) ; Mass spectrum MU 523.9, 52079-23-9

52079-23-9 (S)-(-)-alpha-Hydroxy-gamma-butyrolactone 357853, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/51923; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem