Category: 51856-79-2

Related Products of 51856-79-2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Selective synthesis of pyrrolo[1,2-a]azepines or 4,6-dicarbonyl indoles via tandem reactions of alkynones with pyrrole derivatives. Author is Zhao, Yulei; Yuan, Yang; Xu, Murong; Zheng, Zhong; Zhang, Runhua; Li, Yanzhong.

Methodologies for the selective synthesis of pyrrolo[1,2-a]azepines or 4,6-dicarbonyl indoles starting from pyrrole derivatives and alkynones were described. When reactions were carried out with 1,2,4-trisubstituted N-propargyl pyrroles using a ZnI2 catalyst, pyrrolo[1,2-a]azepines were obtained. Whereas 4,6-dicarbonyl indoles were produced selectively with 1,2-disubstituted pyrroles in the presence of silica gel. The reaction outcomes were dependent on the substituent pattern of the substrates and the nature of the catalysts chosen. Control reactions suggested that the formation of a conjugated enamine intermediate was crucial for both the processes. With easily accessible starting materials, inexpensive catalysts and an easy-to-handle procedure, this reaction had the potential to become a general protocol for the synthesis of pyrrolo[1,2-a]azepines or indoles.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles.

The electrophilic difluoromethylthiolation of indoles I [R = H, F, OMe; R1 = H, Me; R2 = H, Me; R3 = H, Me; R4 = H, Br, tetramethyl-1,3,2-dioxaborolan-2-yl, 1H-indazol-6-yl, etc.; R5 = H, dimethyl-1,2-oxazol-4-yl, 4-(dimethylamino)piperidin-1-yl, [(propan-2-yl)carbamoyl]oxidanyl, etc.; R6 = H; RR1 = -(CH2)3-] with 2-BTSO2CF2H is developed. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded under mild conditions to give products I [R6 = (difluoromethyl)sulfanyl, (trifluoromethyl)sulfanyl, oxo(trifluoromethyl)sulfanyl, (chlorodifluoromethyl)sulfanyl] in modest to high yields. This is a new application of 2-BTSO2CF2H for electrophilic difluoromethylthiolation.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Sweet sorghum stalk liquefaction in supercritical methanol: Effects of operating conditions on product yields and molecular composition of soluble fraction, published in 2017-01-31, which mentions a compound: 51856-79-2, mainly applied to sweet sorghum stalk liquefaction supercritical methanol yield mol composition, Quality Control of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate.

Liquefaction of sweet sorghum stalk (SSS) in supercritical methanol was carried out under different conditions, including temperature, holding time, and SSS-to-methanol ratio. Each reaction mixture was filtrated to afford residue and bio-oil (BO, i.e., methanol-soluble portion). The optimal conditions were determined to be 300 °C and 30 min based on the BO yield and the maximum yield of BO is 40.5 wt% with higher heating value of 25.1 kJ g- 1. Low SSS-to-methanol ratio, i.e., either more methanol volume or less SSS dose, benefits the BO yield. According to gas chromatograph/mass spectrometric anal., the compounds detected in the BOs can be grouped into hydrocarbons, alcs., phenolic compounds (PCs), methoxybenzenes, ketones, esters, and others. Among them, PCs and esters are the most abundant. Guaiacols and alkylphenols are predominant PCs, which were mainly originated from the decomposition of lignin in SSS. Esters can be further classified into long-chain Me esters (LCMEs), short-chain Me esters (SCMEs), di-Me diesters, and polymethyl benzenepolycarboxylates. The variation of esters mainly relied on LCME and SCME change with varied reaction conditions.

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Tetrahydrofuran – Wikipedia,
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Rush Scaggs, W.; Scaggs, Toya D.; Snaddon, Thomas N. published an article about the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2,SMILESS:O=C(OC)CC1=CC=CN1C ).Safety of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:51856-79-2) through the article.

Herein we describe the direct enantioselective Lewis base/Pd catalyzed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products, e.g., I, and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in a manner which points towards potential applications in target directed synthesis.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Application of 51856-79-2.Pitucha, M.; Wujec, M.; Dobosz, M. published the article 《Synthesis of 4-substituted 3-[(1-methylpyrrol-2-yl)methyl]–1,2,4-triazoline-5-thiones》 about this compound( cas:51856-79-2 ) in Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Chemia. Keywords: pyrrolylacetylthiosemicarbazide preparation heterocyclization; triazolethione pyrrolylmethyl preparation. Let’s learn more about this compound (cas:51856-79-2).

Reaction of 1-methylpyrrole-2-acetic acid hydrazide with RNCS gave thiosemicarbazides I [R = Et, cyclohexyl, (un)substituted Ph, benzyl, CH2COOEt], which were cyclized by 2% NaOH to give title compounds II (same R).

From this literature《Synthesis of 4-substituted 3-[(1-methylpyrrol-2-yl)methyl]–1,2,4-triazoline-5-thiones》,we know some information about this compound(51856-79-2)Application of 51856-79-2, but this is not all information, there are many literatures related to this compound(51856-79-2).

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Formula: C8H11NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about C-thiocarbamoylation of electron-rich heterocycles and enamines with amidophosphonium isothiocyanates. Author is Smalii, R. V.; Koidan, G. N.; Chaikovskaya, A. A.; Marchenko, A. P.; Pinchuk, A. M.; Tolmachev, A. A..

Amidophosphonium isothiocyanates can thiocarbamoylate a series of electron-rich heterocycles and enamines at the nucleophilic carbon atom to form phosphazothiocarbonyl compounds From the most active heterocycles, bis(phosphazothiocarbonyl) derivatives can be obtained.

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Maryanoff, Bruce E. published the article 《Reaction of dimethyl diazomalonate and ethyl 2-diazoacetoacetate with N-methylpyrrole》. Keywords: methylpyrrole alkylation regioselectivity diazomalonate diazoacetoacetate; pyrrole alkylation regioselectivity diazomalonate diazoacetoacetate.They researched the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ).Electric Literature of C8H11NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:51856-79-2) here.

N2CH(CO2Me)2 (I) reacts with N-methylpyrrole (II), under metal “”catalysis””, to give pyrrole-malonate adducts III (R = R1 = COMe) and IV (R = R1 = COMe). Yields of adducts are particularly high with Cu(IPSAL)2, Cu(hfacac)2, and Rh2(OAc)4 as promoting agents. The regioselectivity for 2-position substitution is generally higher for I compared to N2CH2CO2Et; also, yields of adducts are generally better with I. N2CH(COMe)CO2Et reacts with II to furnish good yields of monoadduct, which is exclusively composed of the 2-position isomer III (R = COMe, R1 = CO2Et).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Related Products of 51856-79-2.Youngman, Mark A.; Carson, John R.; Lee, Jung S.; Dax, Scott L.; Zhang, Sui-Po; Colburn, Ray W.; Stone, Dennis J.; Codd, Ellen E.; Jetter, Michele C. published the article 《Synthesis and structure-Activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists》 about this compound( cas:51856-79-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: methylquinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; quinolinyloxymethylphenyl aroylpyrrolylalkylamide preparation human bradykinin B2 receptor antagonist; pyrrolylalkylamide methylquinolinyloxymethylphenyl aroyl preparation human bradykinin B2 receptor antagonist; alkylamide methylquinolinyloxymethylphenyl aroylpyrrolyl preparation human bradykinin B2 receptor antagonist; bradykinin B2 receptor binding affinity aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; antinociception aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation; structure activity bradykinin B2 receptor binding aroylpyrrolylalkylamide methylquinolinyloxymethylphenyl preparation. Let’s learn more about this compound (cas:51856-79-2).

The structure-activity relationships of a novel series of aroylpyrrole alkylamides I (R1 = R2 = R3 = Me, R4 = 4-NCC6H4, 3-pyridyl, 2-thienyl, etc.; R1 = Cl, R2 = Me, H, Et, etc., R3 = Me, Et, n-Bu, etc., R4 = 4-NCC6H4, 4-ClC6H4, 3-pyridyl, etc.; n = 1-2) prepared from 3-[(2-methyl-8-quinolinyl)oxymethyl]benzenamine derivatives, as potent selective bradykinin B2 receptor antagonists are described. Several members of this series display nanomolar affinity at the B2 receptor and show activity in an animal model of antinociception, such as I (R1 = Cl, R2 = R3 = Me, R4 = 6-chloro-3-pyridyl, n = 2).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hegedus, Laszlo; Mathe, Tibor researched the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ).Synthetic Route of C8H11NO2.They published the article 《Hydrogenation of pyrrole derivatives. Part V. Poisoning effect of nitrogen on precious metal on carbon catalysts》 about this compound( cas:51856-79-2 ) in Applied Catalysis, A: General. Keywords: hydrogenation pyrrole derivative poisoning nitrogen precious metal carbon catalyst. We’ll tell you more about this compound (cas:51856-79-2).

Poisoning of different precious metals on carbon catalysts (Pd/C, Ru/C and Rh/C) was observed in the hydrogenation of some pyrrole derivatives, under mild reaction conditions, in non-acidic medium. In all reductions, the catalysts were poisoned by the hydrogenated products (pyrrolidines) more strongly than by the reactants (pyrroles). A comparison concerning poison sensitivity of the catalytic metals was also made.

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Reference:
Tetrahydrofuran – Wikipedia,
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SDS of cas: 51856-79-2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Isotope labelling by reduction of nitriles: application to the synthesis of isotopologues of tolmetin and celecoxib. Author is Ellis-Sawyer, Kate; Bragg, Ryan A.; Bushby, Nick; Elmore, Charles S.; Hickey, Michael J..

The process of cyanation of an aryl halide followed by complete reduction of the nitrile to a Me group was investigated as a route for preparing stable and radiolabeled isotopologues of drug-like compounds Using this methodol., carbon-13, deuterium, carbon-14 and tritium labeled isotopologues of the nonsteroidal anti-inflammatory drug tolmetin were produced as well as carbon-13, deuterium and carbon-14 labeled isotopologues of another nonsteroidal anti-inflammatory drug, celecoxib. The radiolabeled compounds were produced at high specific activity and the stable isotope labeled compounds with high incorporation making them suitable for use as internal standards in mass spectrometry assays. This approach provided a common synthetic route to multiple isotopologues of compounds using inexpensive and readily available labeled starting materials.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem