Category: 51856-79-2

Product Details of 51856-79-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Homolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of α-heteroarylacetic acids. Author is Baciocchi, Enrico; Muraglia, Ester; Sleiter, Giancarlo.

Efficient and selective homolytic substitutions (55-90% yields) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe2+/H2O2 and α-cyano-, α-carbonyl-, and α,α’-dicarbonylalkyl iodides. The reaction is highly successful with pyrroles substituted by electron-withdrawing groups, which allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described. Thus, homolytic substitution of pyrrole with ICHRR1 (R = H, R1 = CO2Me, cyano; R = R1 = CO2Me) gave 2-substituted pyrroles I.

This compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Product Details of 51856-79-2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N-Arylation Reactions, the main research direction is photoredox aryloxyamide amidyl radical hydroamination cyclization arylation mechanism; aryloxy amide preparation photoredox hydroamination cyclization arylation; electrochem potential aryloxyamide bond dissociation energy; transition metal free photoredox amidyl radical preparation.Application of 51856-79-2.

The development of photoredox reactions of aryloxy-amides for the generation of amidyl radicals and their use in hydroamination-cyclization and N-arylation reactions is reported. Owing to the ease of single-electron-transfer reduction of the aryloxy-amides, the organic dye eosin Y was used as the photoredox catalyst, which results in fully transition-metal-free processes. These transformations exhibit a broad scope, are tolerant to several important functionalities, and have been used in the late-stage modification of complex and high-value N-containing mols.

This compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Application of 51856-79-2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 51856-79-2, is researched, Molecular C8H11NO2, about Replacement of aromatic or heteroaromatic groups in nonsteroidal antiinflammatory agents with the ferrocene group, the main research direction is antiinflammatory agent ferrocene analog; tolmetin ferrocene analog; fenbufen ferrocene analog.Formula: C8H11NO2.

Ferrocene analogs of the antiinflammatory agents tolmetin, fenbufen, flurbiprofen and fenclofenac were synthesized and tested for biol. activity. The derivatives exhibited little or no antiarthritic or platelet antiaggregatory activity, indicating that the ferrocene moiety is a poor bioisostere for aromatic or heteroaromatic groups in nonsteroidal antiinflammatory agents.

This compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Formula: C8H11NO2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Friedel-Crafts Acylation of Pyrroles and Indoles using 1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) as a Nucleophilic Catalyst. Author is Taylor, James E.; Jones, Matthew D.; Williams, Jonathan M. J.; Bull, Steven D..

1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) has been shown to be an effective catalyst for the regioselective Friedel-Crafts C-acylation of pyrroles and indoles in high yields. A detailed mechanistic study implies that DBN is acting as a nucleophilic organocatalyst, and the X-ray crystal structure of a key N-acyl-amidine intermediate have been determined for the first time.

《Friedel-Crafts Acylation of Pyrroles and Indoles using 1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) as a Nucleophilic Catalyst》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Quality Control of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C8H11NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Reaction of substituted N-methylbenzimidoyl chlorides with pyrrole-2-acetate esters. Author is Mills, John E.; Cosgrove, Robin M.; Shah, Rekha D.; Maryanoff, Cynthia A.; Paragamian, Vasken.

4-RC6H4CCl:NMe (I; R = H, Me, OMe, Cl, NO2) react with pyrroleacetates II (R1 = H, Me) to give 30-69% ketimines III. The acid-catalyzed substitution is enhanced by electron-withdrawing substituents and retarded by electron-donating substituents on I.

《Reaction of substituted N-methylbenzimidoyl chlorides with pyrrole-2-acetate esters》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Synthetic Route of C8H11NO2.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application In Synthesis of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity. Author is Mai, Antonello; Massa, Silvio; Cerbara, Ilaria; Valente, Sergio; Ragno, Rino; Bottoni, Patrizia; Scatena, Roberto; Loidl, Peter; Brosch, Gerald.

Previous SAR studies performed on some portions (pyrrole-C4, pyrrole-N1, and hydroxamate group) of 3-(4-benzoyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide (I) highlighted the I-4-phenylacetyl and I-4-cinnamoyl analogs as more potent compounds in inhibiting maize HD2 activity in vitro. In the present paper, we investigated the effect on anti-HD2 activity of chem. substitutions performed on the pyrrole-C2 ethene chains of I and analogs, which were replaced with methylene, ethylene, substituted ethene, and 1,3-butadiene chains. Biol. results clearly indicated the unsubstituted ethene chain as the best structural motif to get the highest HDAC inhibitory activity, the sole exception to this rule being the introduction of the 1,3-butadienyl moiety into the I chem. structure. IC50 values of compounds prepared as I homologues revealed that between benzene and carbonyl groups at the pyrrole-C4 position a hydrocarbon spacer length ranging from two to five methylenes is well accepted by the APHA template, while the introduction of a higher number of methylene units decreased the inhibitory activities of the derivatives Conformationally constrained forms of I analogs, prepared with the aim to obtain some information potentially useful for a future 3D-QSAR study, showed the same or higher HD2 inhibiting activities in comparison with those of the reference drugs. Mol. modeling and docking calculations on the designed compounds performed in parallel with the chem. work fully supported the synthetic effort and gave insights into the binding mode of the more flexible APHA derivatives

The article 《3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity》 also mentions many details about this compound(51856-79-2)Application In Synthesis of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Reaction of pyrroles with naphthoquinones. Synthesis of new pyrrolylnaphthoquinone dyes.Synthetic Route of C8H11NO2.

The reaction of 1,4-naphthoquinone with N-alkylpyrroles gives a mixture of 2-(pyrrol-2-yl)-1,4-naphthoquinones and 2,5-bis(1,4-naphthoquinon-2-yl)pyrroles. The yields and the ratios of these two products depend greatly on the exptl. conditions. The reaction has been extended to 5-hydroxy-1,4-naphthoquinone and 1,2-naphthoquinone. New pyrrolylnaphthoquinone dyes are obtained.

The article 《Reaction of pyrroles with naphthoquinones. Synthesis of new pyrrolylnaphthoquinone dyes》 also mentions many details about this compound(51856-79-2)Synthetic Route of C8H11NO2, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Product Details of 51856-79-2.Reddy, Lekkala Amarnath; Chakraborty, Saurya; Swapna, Rodda; Bhalerao, Dinesh; Malakondaiah, Golla China; Ravikumar, Mylavarapu; Kumar, Abhijeet; Reddy, Gade Srinivas; Naram, Jyothirmayi; Dwivedi, Namrata; Roy, Arnab; Himabindu, Vurimidi; Babu, Bangaru; Bhattacharya, Apurba; Bandichhor, Rakeshwar published the article 《Synthesis and Process Optimization of Amtolmetin: An Antiinflammatory Agent》 about this compound( cas:51856-79-2 ) in Organic Process Research & Development. Keywords: amtolmetin intermediate tolmetin preparation electrophilic substitution reduction optimization. Let’s learn more about this compound (cas:51856-79-2).

Efforts toward the synthesis and process optimization of amtolmetin guacil (1) are described. High-yielding electrophilic substitution followed by Wolff-Kishner reduction are the key features in the synthesis of tolmetin, which is an advanced intermediate of 1.

After consulting a lot of data, we found that this compound(51856-79-2)Product Details of 51856-79-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C8H11NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands. Author is Crawforth, James; Atack, John R.; Cook, Susan M.; Gibson, Karl R.; Nadin, Alan; Owens, Andrew P.; Pike, Andrew; Rowley, Michael; Smith, Alison J.; Sohal, Bindi; Sternfeld, Francine; Wafford, Keith; Street, Leslie J..

A series of tricyclic pyridones has been evaluated as benzodiazepine site ligands with functional selectivity for the α3 over the α1 containing subtype of the human GABAA receptor ion channel. This investigation led to the identification of a high affinity, functionally selective, orally bioavailable benzodiazepine site ligand that demonstrated activity in rodent anxiolysis models and reduced sedation relative to diazepam.

After consulting a lot of data, we found that this compound(51856-79-2)Computed Properties of C8H11NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C8H11NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Hydrogenation of pyrrole derivatives. Part VI. An exception: catalytically unhydrogenatable pyrroles. Author is Hegedus, Laszlo; Mathe, Tibor; Keglevich, Gyorgy.

Pyrrole derivatives I (R = Me, H) and II were found to be catalytically unhydrogenatable during the systematic investigation of heterogeneous catalytic hydrogenation of several pyrroles. These compounds cannot be hydrogenated over precious metal (Pd, Ru, Rh) or Raney nickel catalysts, even under extreme reaction conditions (130°, 100 bar), in the liquid phase.

Although many compounds look similar to this compound(51856-79-2)Synthetic Route of C8H11NO2, numerous studies have shown that this compound(SMILES:O=C(OC)CC1=CC=CN1C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem