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Synthesis and anticancer activity of 4-aza-daurinol derivatives

Daurinol, a natural aryl naphthalene lactone, has been reported to have antiproliferative activity against various cell lines, and has also been shown to be efficacious in an in vivo xenograft mouse model. In this study, we tried to discover a new scaffold that enables both rapid structure-activity relationship study of daurinol and scalable synthesis of active compounds. 4-Aza-daurinol, a bioisosterism-based scaffold of daurinol, was designed and 17 analogues were synthesized and evaluated against five representative cancer cell lines. Among them, the 2,3-dihydrobenzo[b][1,4]dioxinyl derivative was found to be the most potent and showed similar activity and tendency as daurinol.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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[bmIm]OH catalyzed coupling: Green and efficient synthesis of 2,8 dioxacyclopenta [a] inden-3-one derivatives in an aqua media

An efficient recyclable [bmIm]OH catalyzed and aqua mediated eco-compatible synthesis of biologically versatile 2,8 dioxacyclopenta [a] inden-3-one derivatives. Combination of ionic liquid and water has emerged out as a powerful synthetic tool for constructing C?C, C?S and C?O bonds. Disclosed methodology for introducing broad range of 2-iodophenols, 2-iodothiophenols and tetronic acid in basic ionic liquid with predictable high yield will catch the attention of synthetic chemists. This protocol has documented the notable advances and the applications of ionic liquid in heterocyclic synthesis. The chosen strategy illustrates important issues regarding scope, reactivity, product yield, reaction time, reuse and recyclability that will help in designing new synthetic routes for other heterocyclic synthesis.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C4H4O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4971-56-6, in my other articles.

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Synthesis and bio-evaluation of phenothiazine derivatives as new anti-tuberculosis agents

Abstract Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Multiclass method for pesticides quantification in honey by means of modified QuEChERS and UHPLC-MS/MS

Bee products can be produced in an environment contaminated by pesticides that can be transported by honey bees to the hive and incorporated into the honey. Therefore, rapid and modern methods to determine pesticide residues in honey samples are essential to guarantee consumers’ health. In this study, a simple multiresidue method for the quantification of 116 pesticides in honey is proposed. It involves the use of a modified QuEChERS procedure followed by UHPLC-MS/MS analysis. The method was validated according to the European Union SANCO/12571/2013 guidelines. Acceptable values were obtained for the following parameters: linearity, limit of detection (0.005 mg/kg) and limit of quantification (0.010 and 0.025 mg/kg), trueness (for the four tested levels the recovery assays values were between 70 and 120%), intermediate precision (RSD < 20.0%) and measurement uncertainty tests (<50.0%). The validated method was applied for determination of 100 honey samples from five states of Brazil. One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Furan-2,4(3H,5H)-dione, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4971-56-6

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A direct ylide transfer to carbonyl derivatives and heteroaromatic compounds

Power transfer: The title reaction proceeds under mild conditions (room temperature, short reaction times) and directly affords sulfonium ylides from active methylene compounds and heteroaromatics in a single step and in high yields. A detailed comparative structural analysis of a variety of ylides is presented and the implications of structure on the reactivity of these compounds are discussed.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Ionic liquid promoted eco-friendly and efficient synthesis of six-membered N-polyheterocycles

Background: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the literature related to the total synthesis of six-membered N-polyheterocycles. Objective: Ionic liquids not only acted as environmentally benign reaction media but also as catalysts which afforded the very promising replacements of traditional molecular solvents in organic chemistry due to their stability, non-flammability, non-volatility and ease of recyclability. Ionic liquids are utilized in metal catalyzed reactions in place of organic solvents in the last years. It has attracted considerable attention in recent years. Ionic liquids acted as alternatives of organic solvents and these ILs are environment friendly. Conclusion: In the area of green chemistry ionic liquid assisted synthesis is a very promising technique which afforded a flexible platform for the formation of heterocycles. The influence of ILs on the development of efficient and new synthetic protocols over the last decade for the construction of N-polyheterocycles is featured in this review article. These synthetic strategies will continue to attract more attention and will find a wide range of applications in organic synthesis. In conclusion, ionic liquids assisted syntheses have become an efficient and powerful tool in organic chemistry quickly.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis and Antifungal Activity of Novel Furan-2,4-dione Derivatives Containing Substituted Phenylhydrazine Moiety

A series of novel 3-(2-(substituted phenyl)hydrazinylmethylidene)furan-2,4(3H,5H)-diones were designed and synthesized with ethyl 4-chloroacetoacetate as the starting material. Their structures were confirmed by FT-IR, 1H NMR, 13C NMR, EI-MS and elemental analysis. Bioassay data demonstrated that these compounds exhibited remarkable antifungal activity against Fusarium graminearum, Botrytis cinerea, Rhizoctonia cerealis and Colletotrichum capsici. Compound 3-(2-(4-bromophenyl)hydrazinylmethylidene)furan-2,4(3H,5H)-dione (5g) had excellent bioactivity against Botrytis cinerea with an EC50 value of 0.18 mug/mL – markedly lower than the 0.24 mug/mL of the commercial fungicide procymidone. The result revealed that introducing the halogenated phenylhydrazine at the 3-position of furan-2,4(3H, 5H)-dione was an effective way to design new tetronic acid derivatives as new fungicides. A series of novel furan-2,4-dione derivatives containing a substituted phenylhydrazine moiety were designed and synthesized. These compounds exhibited remarkable antifungal activity against Fusarium graminearum, Botrytis cinerea, Rhizoctonia cerealis and Colletotrichum capsici. Compound 5g showed significantly better bioactivity than the control fungicides.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Application of 4971-56-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4971-56-6, molcular formula is C4H4O3, introducing its new discovery.

Marine fungal substances

This review concerns substances produced by fungi isolated from the marine environment (seas, estuaries, brackish waters, salt marshes) which are capable of reproducing in a salt medium. Enzymatic activities and known primary or secondary metabolites are discussed in chemical, biochemical and biological terms. The potential industrial and pharmaceutical applications of these substances are considered as well as their potential toxic incidence for aquaculture and public health.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to Tetrahydrofurans compound, is a common compound. Recommanded Product: Furan-2,4(3H,5H)-dioneIn an article, once mentioned the new application about 4971-56-6.

Methods of treating hypertension and pharmaceutical compositions comprising 1-tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents

This invention relates to methods of treating hypertension and pharmaceutical compositions comprising a class of 1-tertiary-alkyl-3-(substituted furyl)ureas that exhibit antihypertensive activity in warm-blooded animals. A representative compound is 1-tert-butyl-3-(2,5-dihydro-5-oxo-3-furyl)urea.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Synthesis of new stable crystalline zwitterionic products from the reactions of 1-methylimidazole, acetylenic esters and strong cyclic CH-acids

The reactive 1:1 intermediate produced in the reaction between 1-methylimidazole and dialkyl acetylenedicarboxylates was trapped by strong cyclic CH-acids such as N,N?-dimethylbarbituric acid, Meldrum’s acid, cyclohexan-1, 3-dione, indan-1,3-dione, cyclopentan-1,3-dione and tetronic acid to yield stable 1,4-diionic imidazolium betaines in excellent yields.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem