Category: 42417-39-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

(1) Under ice water bath conditions, 169 mg (0.93 mM) of (R)-(+)-alpha-amino-gamma-butyrolactone hydrochloride and 0.93 mM of p-bromobenzylsulfonyl chloride were placed in 10 mL of dry CH2Cl2 solution and mixed evenly. Afterwards, add 267 mg (1.5 mM) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 68 mg (0.6 mM) of 4-dimethylaminopyridine (DMAP). After stirring for 30 min, the ice bath was removed and the reaction was continued for 20 h at room temperature.(2) The solution after the reaction was diluted to CH2Cl2 to a final volume of 100 mL, and the solution was washed three times with an equal volume of 10% (v / v) HCl solution and saturated NaCl solution in a separatory funnel. After the organic phase solution was collected, the residual water in the organic phase was removed by addition of anhydrous MgSO4 and dried at 50 C by rotary evaporator to give the crude product. The crude product was purified by SiO2 column chromatography, TLC, ethyl acetate: petroleum ether = 1.5: 1. The eluate was rotated by rotary evaporator at 50 C and the oil pump was decompressed under reduced pressure to obtain the desired product.

42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; Lanzhou University; Li, Hongyu; Zhao, Yang; Liu, Yingqian; (9 pag.)CN106146432; (2016); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

As shown in FIG. 3, a desamination reaction (second reaction) of homoserine lactone hydrochloride using water as a solvent was carried out.A portion of the upper layer recovered in the first reaction (80.2 mL)And 120 g of HSL ¡¤ HCl were placed in a reactor and reacted while injecting NO / Air (O 2) gas at room temperature (25 C.) and atmospheric pressure (1 atm). GC analysis was performed to confirm the presence of unreacted HSL ¡¤ HCl, and the product was placed in a separating funnel and allowed to stand until it was separated.64.04 g of the bottom layer was recovered from the layered solution and the recovered bottom layer was evaporated under reduced pressure (2-4 torr) to 50 & lt; 0 & gt; C to recover 58.28 g of product. As a result of analyzing the components of the product, Cl-GBL contained 91.34%, HO-GBL contained 5.04%, and furanone contained 2.62%.After separating the lower layer, the upper layer was 154.05 g, and 80 mL (94.25 g) was used as a solvent for the tertiary reaction. The residue (59.8 g) was extracted three times with chloroform (60 mL / 60 mL / 60 mL) and the combined extracts were evaporated under reduced pressure to recover 18.57 g of product. As a result of analyzing the components of the product, 87.36% of Cl-GBL, 4.11% of HO-GBL and 7.37% of furanone were contained.After the chloroform extraction, the solvent was evaporated under reduced pressure to recover 7.8 g of the product. As a result of analyzing the components of the product, Cl-GBL was contained in 2.28%, HO-GBL in 91.44%, and furanone in 0.92%.

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4-(5-(substituted phenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (0.53mmol)in 10mL DCM was added methyl glycinate hydrochloride (0.80mmol), acetic acid (2.12mmol), and N,N-diisopropylethylamine (0.80mmol), and 10mL MeOH. After the reaction was stirred for 3h, sodium cyanoborohydride (0.53mmol) was added. The reaction mixture was quenched with saturated aqueous NaHCO3 solution and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4, then filtered and concentrated. The residue was purified by silica gel flash column chromatography (DCM:MeOH=20:1) to afford compound 15-1a?15-3n (except for 15-1l).

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Tianqi; Jin, Jing; Chen, Yonghui; Xi, Qiumu; Hu, Jinping; Jia, Wenqiang; Chen, Xiaoguang; Li, Yan; Wang, Xiaojian; Yin, Dali; Bioorganic Chemistry; vol. 82; (2019); p. 41 – 57;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem