42417-39-0| Heterocyclic Building Blocks-Tetrahydrofuran

Simple exploration of 42417-39-0

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42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42417-39-0

The reactor was charged with 0.5 g of HSL.HCl and 6.5 g of water as a reactant. An Fe (NO3) 3 catalyst was added to the reactor in the ratio shown in Table 5 below to carry out the deamination reaction of HSL ¡¤ HCl. The reaction conditions were 25 C and 1 atm. The product was partially recovered and the components were analyzed. The results are shown in Table 5 below.

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Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some tips on 42417-39-0

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

The reactor was charged with 1 g of HSL ¡¤ HCl, 40 g of methanol and 0.05 g of Pt (5) / Ac, followed by NO / N2 (15 atm, 1: 1 (v / v) As above, additional H2 (6.5 atm) was added and the desmethylation reaction of HSL.HCl was performed. The product was partially recovered and the components were analyzed. The results are shown in Table 8 below.

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Analyzing the synthesis route of 42417-39-0

42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Under ice bath conditions, 20 g of the amination product white solid was mixed with tetrahydrofuran and water, sodium carbonate was added thereto, and 30 g of benzyl chloroformate was slowly added dropwise to the reaction for half an hour, and then returned to room temperature and then continued. After reacting for 2 hours, the solvent was distilled off under reduced pressure, the pH was adjusted to acidity, and extracted with dichloromethane to give a crude compound of formula IV.Filtration of the product colorless oily liquid 13.54g, yield 90%.

42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Wuhan Institute of Technology; Jia Lihui; Chen Yunfeng; Chen Changan; (10 pag.)CN109232644; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

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The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

The batch reactor was charged with 2 g of each of HSL ¡¤ HCl, HS (homoserine) and HSL (homoserine lactone free salt) as reactants. 40 g of water and 0.1 g of Pt (5) / Ac were placed in the reactor, and the reaction for the homo-serine compound was performed under the conditions shown in Table 4 below. The product was partially recovered according to the elapsed time of the reaction, and the components were analyzed. The results are shown in Table 4 below.

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The autocatalytic reaction of homoserine lactone hydrochloride was performed using a high pressure reaction system. Specifically, 2 g of HSL.HCl, 45 g of chloroform and 1 g of conc. HCl was added to the reactor and reacted with NO / Air (O2) gas at room temperature (25 ) and high pressure (about 14 atm). After 2 hours of reaction, the product was recovered and the components were analyzed as 92.7% of Cl-GBL, 3.3% of HO-GBL, 3.8% of furanone and 0.2% of other components.

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Downstream synthetic route of 42417-39-0

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42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To synthesize 3-oxo-phenylacyl homoserine lactones, 400 mg of PS-carbodiimide resin (Argonaut Technologies) (793.65 g/mol; 0.504 mmol; 2.0 mol equiv) was added to a 10 mL reactivial (Pierce). To the reactivial, phenylacylcarboxylic acid (1.0 mol equiv), 2,2-dimethyl-l,3-dioxane-4,6-dione (Meldrum’s acid; 1.0 mol equiv), and 4,4- dimethylarainopyridine (1.05 mol equiv) were added with ~5 mL dichloromethane. The reaction was allowed to stir overnight at room temperature. Upon completion, the resin was removed by filtration, and the solvents were evaporated. Product was redissolved in ethyl acetate and washed with 0. IN HCl. The organic layer was dried over magnesium sulfate, which was removed by filtration. The solvents were removed in vacuo and the final product was dissolved in ~5 mL acetonitrile and transferred to a 10 mL reactivial (Pierce). To the reactivial, ?-aminobutryolactone HCl (1.0 mol equiv) and triethylamine (1.2 mol equiv) were added. The reaction mixture was then irradiated by microwave for 10 min at IOOW twice. Upon completion of microwave reaction, solvents were removed in vacuo. Crude product was redissolved in ethyl acetate with minimal water to aid solubility and washed once each with saturated Sodium bicarbonate, IM Potassium bisulfate, and saturated Sodium Chloride. The organic layer was dried over magnesium sulfate, which was removed by filtration. Solvents were removed in vacuo and the resulting product was redissolved in a minimal volume of ethyl acetate and loaded onto a 2Og flash chromatography column. The final product was purified by flash chromatography (Flashmaster system; Argonaut Technologies) using the gradient system shown in Table 1. Table 1.Fractions were collected and analyzed by thin layer chromatography (80:20 Ethyl acetate/hexanes). Fractions containing product were collected and solvents were removed in vacuo. The final product was confirmed by H-NMR and mass spectrometry (H-NMR results presented in Example 14).

42417-39-0, The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEALTH RESEARCH INC.; DOLNICK, Bruce, J.; WO2006/110531; (2006); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 42417-39-0

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42417-39-0

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Brief introduction of 42417-39-0

42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of Butoxy-SHL (1) To a solution of 3,4-dibutoxy-cyclobut-3-ene-1,2-dione (0.120 g, 0.53 mmol) in DMF at rt was added alpha-Amino-gamma-butyrolactone-hydrochloride (0.070 g, 0.38 mmol) and triethylamine (1.5 equiv.) and the mixture refluxed overnight. The completion of the reaction was monitored by TLC for the disappearance of starting material. The reaction was quenched with water and extracted with EtOAc (3*100 mL). The organic layers were collected, washed with brine (2*25 mL), dried over Na2SO4 and concentrated in vacuo. Flash column chromatography (SiO2, 100% EtOAc) yielded compound 1 as a brown solid.

42417-39-0, 42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SYRACUSE UNIVERSITY; Luk, Yan-Yeung; Narasimhan, Sri Kamesh; Falcone, Eric; US2014/39195; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Dissolving 3-chloro-4-(5-(4-isopropoxy-3-cyanophenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (200 mg, 0.54 mmol) In 35 ml of dichloromethane,Add to it in orderDL-homoserine lactone hydrochloride(112mg, 0.82mmol), glacial acetic acid (0.12ml, 2.18mmol), N,N-diisopropylethylamine (0.13ml, 0.82mmol), 5ml of methanol, reacted at room temperature for 3h, then added sodium cyanoborohydride (34mg , 0.47 mmol), reacted under argon for 5 h. A saturated sodium hydrogencarbonate solution was added, and the mixture was extracted with dichloromethane (3¡Á30 mL). Concentrated and separated by column chromatography. The eluent was dichloromethane: methanol = 20:1.A white solid 154 mg was obtained in a yield of 62.5%.

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Wang Xiaojian; Liu Tianqi; Jin Jing; Hu Jinping; Chen Xiaoguang; Yin Dali; (70 pag.)CN109956912; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 42417-39-0

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42417-39-0

The reactor was charged with HSL ¡¤ HCl, methanol and / or water as described in Table 9 below. The reactor was charged with Pt (5) / Ac and NO / N2 (15 atm, 1: 1 (v / v)). The reaction was carried out at a reaction time and a reaction temperature as shown in Table 9 below. The product was partially recovered and the components were analyzed. The results are shown in Table 9 below.

42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various fields.