Category: 4221-99-2

HPLC of Formula: 4221-99-2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Integrative self-assembly of covalent organic frameworks and fluorescent molecules for ultrasensitive detection of a nerve agent simulant. Author is Gong, Yanjun; Guo, Yongxian; Qiu, Changkun; Zhang, Zongze; Zhang, Fenghua; Wei, Yanze; Wang, Shuping; Che, Yanke; Wei, Jingjing; Yang, Zhijie.

Binding of fluorescent mols. to the porous matrix through noncovalent interactions will synergistically expand their application spectrum. In this regard, we report an integrative self-assembly of mol. 1 with benzothiadizole and 9,9-dihexyl fluorene units, and covalent organic frameworks (COFs) via an emulsion-modulated polymerization process, within which mols. of 1 are able to interact with the scaffolds of COFs through CH-π interactions. Thus the π-π interactions between the fluorescent mols. are largely suppressed, giving rise to their remarkable monomer-like optical properties. Of particular interest is that, given by the specific interaction between COFs and a nerve agent simulant di-Et chlorophosphite (DCP), these assembled composites show the ability of ultrasensitive detection of DCP with a detection limit of ~40 ppb. Moreover, the present integrative assembly strategy can be extended to encapsulate multiple fluorescent mols., enabling the assemblies with white light emission. Our results highlight opportunities for the development of highly emissive porous materials by mol. self-assembly of fluorophores and mol. units of COFs.

From this literature《Integrative self-assembly of covalent organic frameworks and fluorescent molecules for ultrasensitive detection of a nerve agent simulant》,we know some information about this compound(4221-99-2)HPLC of Formula: 4221-99-2, but this is not all information, there are many literatures related to this compound(4221-99-2).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C4H10O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Important Phase Control of Indium Sulfide Nanomaterials by Choice of Indium(III) Xanthate Precursor and Thermolysis Temperature. Author is Masikane, Siphamandla C.; McNaughter, Paul D.; Lewis, David J.; Vitorica-Yrezabal, Inigo; Doyle, Bryan P.; Carleschi, Emanuela; O’Brien, Paul; Revaprasadu, Neerish.

Four In(III) xanthate complexes, [In(S2COR)3] where R = Me, Et, iPr and sBu, resp., were synthesized, characterized and subsequently used as single source mol. precursors via a solventless thermolysis route to obtain In sulfide materials. By choice of precursor and reaction temperature crystalline powders of tetragonal In2S3, cubic In2S3 and cubic In2.77S4 were acquired. The phase identification and purity were conducted through examination of the exptl. powder x-ray diffraction patterns relative to the simulated patterns for single X-ray crystal diffraction.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC)COA of Formula: C4H10O, and with the development of science, more effects of this compound(4221-99-2) can be discovered.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Butan-2-ol(SMILESS: C[C@H](O)CC,cas:4221-99-2) is researched.Category: pyrazines. The article 《Supramolecular organogel formation through three-dimensional α-cyclodextrin nanostructures: solvent chirality-selective organogel formation》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:4221-99-2).

Novel supramol. organogels were efficiently formed by mixing a 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solution of α-cyclodextrin (α-CD) with 1- or 2-butanol via the formation of three-dimensional hexagonal nanostructures composed of head-to-tail α-CD channel assemblies. Mixing (R)- and (S)-2-butanol with an α-CD/HFIP solution realized (S)-2-butanol-selective organogel formation.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC)Product Details of 4221-99-2, and with the development of science, more effects of this compound(4221-99-2) can be discovered.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4221-99-2, is researched, SMILESS is C[C@H](O)CC, Molecular C4H10OJournal, Article, Angewandte Chemie, International Edition called Controlling the Multiple Chiroptical Inversion in Biphasic Liquid-Crystalline Polymers, Author is Cheng, Xiaoxiao; Miao, Tengfei; Ma, Yafei; Zhu, Xiaoyan; Zhang, Wei; Zhu, Xiulin, the main research direction is chirality self assembly liquid crystalline aggregation supramol stacking chiroptical; azobenzene; chirality; liquid-crystalline polymers; polymerization-induced self-assembly; supramolecular chemistry.Quality Control of (S)-Butan-2-ol.

While controlling the chirality and modulating the helicity is a challenging task, it attracts great research interest for gaining a better understanding of the origin of chirality in nature. Herein, structurally similar azobenzene (Azo) vinyl monomers were designed in which the alkyl chains comprised the chiral stereocenter with different achiral tail lengths. Combining the synchronous polymerization, supramol. stacking and self-assembly, the multiple chiroptical inversion of the Azo-polymer supramol. assemblies can be modulated by the tail length and DP of Azo blocks during in situ polymerization The DP-, UV light-, temperature-, aging time-dependent chiroptical properties and liquid-crystalline (LC) characterization indicated that the amorphous-to-LC phase transition and biphasic LC interconversion allow the transcription of intra-chain π-π stacking, inter-chain H- and J-aggregation, thereby controlling the dynamic multiple reversal of supramol. chirality.

There is still a lot of research devoted to this compound(SMILES：C[C@H](O)CC)Quality Control of (S)-Butan-2-ol, and with the development of science, more effects of this compound(4221-99-2) can be discovered.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fernandez-Maestre, Roberto; Doerr, Markus published an article about the compound: (S)-Butan-2-ol( cas:4221-99-2,SMILESS:C[C@H](O)CC ).SDS of cas: 4221-99-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4221-99-2) through the article.

Racemic mixtures of twelve common α-amino acids and three chiral drugs were tested for the separation of their enantiomers by ion mobility spectrometry (IMS)-quadrupole mass spectrometry (MS). Separations were tested by introducing chiral selectors in the mobility spectrometer buffer gas. (R)-α-(trifluoromethyl) benzyl alc., (R)-tetrahydrofuran-2-carbonitrile, (L)-Et lactate, Me (S)-2-chloropropionate, and the R and S enantiomers of 2-butanol and 1-Ph ethanol were evaluated as chiral selectors. Exptl. conditions were varied during the tests including buffer gas temperature, concentration, and type of chiral selectors, analyte concentration, electrospray voltage, electrospray (ESI) solvent pH, and buffer gas flow. The individual enantiomers yielded different drift times for periods of up to 8 h in a few experiments; such drift times were sufficiently different (~0.3 ms) to partially resolve the enantiomers in racemic mixtures, but these mixtures always yielded a single mobility peak at the exptl. conditions tested with a drift time similar to that of one of the enantiomers. Energy calculations of the chiral selector-ion interactions showed that these separations are unlikely using 2-butanol as chiral selector but they might be feasible depending on the nature of chiral selectors and the type of enantiomers.

From this literature《On the separation of enantiomers by drift tube ion mobility spectrometry》,we know some information about this compound(4221-99-2)SDS of cas: 4221-99-2, but this is not all information, there are many literatures related to this compound(4221-99-2).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Butan-2-ol( cas:4221-99-2 ) is researched.Category: tetrahydrofurans.Larsen, Jens; Lambert, Maja; Pettersson, Henrik; Vifian, Thomas; Larsen, Mogens; Ollerstam, Anna; Hegardt, Pontus; Eskilsson, Cecilia; Laursen, Steen; Soehoel, Anders; Skak-Nielsen, Tine; Hansen, Lene M.; Knudsen, Nina Oe.; Eirefelt, Stefan; Soerensen, Morten D.; Stilou, Tatiana G.; Nielsen, Simon F. published the article 《Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “”Dual-Soft”” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis》 about this compound( cas:4221-99-2 ) in Journal of Medicinal Chemistry. Keywords: isobutyl methoxyoxo isobenzofuranyl triazolopyridinyl cyclopropanecarboxylate LEO 39652 preparation; PDE4 inhibitor topical stability atopic dermatitis LEO 39652 metabolism. Let’s learn more about this compound (cas:4221-99-2).

We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft) while being stable in human skin. Compound 40 was selected as a clin. candidate as it was potent and rapidly degraded by blood and liver to inactive metabolites and because in preclin. studies it showed high exposure at the target organ: the skin. Preclin. and clin. data are presented confirming the value of the dual-soft concept in reducing systemic exposure.

From this literature《Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “”Dual-Soft”” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis》,we know some information about this compound(4221-99-2)Category: tetrahydrofurans, but this is not all information, there are many literatures related to this compound(4221-99-2).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Category: tetrahydrofurans. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Ultrasensitive Detection of Sulfur Mustard via Differential Noncovalent Interactions. Author is Qiu, Changkun; Liu, Xiaoling; Cheng, Chuanqin; Gong, Yanjun; Xiong, Wei; Guo, Yongxian; Wang, Chen; Zhao, Jincai; Che, Yanke.

In this work, we fabricate two types of hierarchical microspheres, i.e., one coassembled from two fluorene-based oligomers (I and II) and one self-assembled from a fluorene-based oligomer (I), for ultrasensitive and selective detection of trace sulfur mustard (SM) vapor. On the basis of distinct fluorescence responses of I-II coassembled and individual I hierarchical microspheres that originate from differential noncovalent interactions between analytes and these sensors, SM vapor can be ultrasensitively detected (30 ppb) and easily discriminated from various sulfides and other potential interferents. Our work that utilizes differential noncovalent interactions to give sensitive and selective fluorescence response patterns represents a new detection approach for SM and other hazardous chems.

From this literature《Ultrasensitive Detection of Sulfur Mustard via Differential Noncovalent Interactions》,we know some information about this compound(4221-99-2)Category: tetrahydrofurans, but this is not all information, there are many literatures related to this compound(4221-99-2).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Emergent Self-Assembly Pathways to Multidimensional Hierarchical Assemblies using a Hetero-Seeding Approach, the main research direction is self assembly multidimensional hierarchy nanostructure seeding perylenediimide; hetero-seeding; hidden self-assembly pathways; hierarchical structures; perylenediimide-based molecules; self-assembly.Application of 4221-99-2.

The controlled formation of complex and functional 1-, 2-, and 3-dimensional hierarchical assemblies from mol. building blocks represents a key current challenge. Herein, the authors report the use of a seeded growth approach for perylenediimide-based mols. (PDIs 1-4) to access otherwise inaccessible self-assembly pathways that yield complex hierarchical structures. The key to the new approach is to use hetero-seeds which possess a different composition and morphol. from that of the mol. building block. For example, a nanotube seed (from PDI 3) and a microribbon seed (from PDI 4) initiate different self-assembly pathways for PDI 1, which normally assembles to yield nanocoils. This gave unprecedented 3-dimensional scroll-like and scarf-like hierarchical nanostructures, resp. Also, the hetero-seeds from PDI 3 initiate hidden self-assembly pathways of PDI 2 to generate 1-dimensional tubular heterojunctions. Significantly, this new strategy offers new opportunities to create emergent and functional hierarchical and complex structures from small mol. precursors.

In some applications, this compound(4221-99-2)Application of 4221-99-2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application In Synthesis of (S)-Butan-2-ol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Ultrafast gas chromatography coupled to electronic nose to identify volatile biomarkers in exhaled breath from chronic obstructive pulmonary disease patients: A pilot study. Author is Rodriguez-Aguilar, Maribel; Ramirez-Garcia, Sofia; Ilizaliturri-Hernandez, Cesar; Gomez-Gomez, Alejandro; Van-Brussel, Evelyn; Diaz-Barriga, Fernando; Medellin-Garibay, Susanna; Flores-Ramirez, Rogelio.

An anal. method to identify volatile organic compounds (VOCs) in the exhaled breath from patients with a diagnosis of chronic obstructive pulmonary disease (COPD) using a ultrafast gas chromatog. system equipped with an electronic nose detector (FGC eNose) has been developed. A prospective study was performed in 23 COPD patients and 33 healthy volunteers; exhalation breathing tests were performed with Tedlar bags. Each sample was analyzed by FCG eNose and the identification of VOCs was based on the Kovats index. Raw data were reduced by principal component anal. (PCA) and canonical discriminant anal. [canonical anal. of principal coordinates (CAP)]. The FCG eNose technol. was able to identify 17 VOCs that distinguish COPD patients from healthy volunteers. At all stages of PCA and CAP the discrimination between groups was obvious. Chem. prints were correctly classified up to 82.2%, and were matched with 78.9% of the VOCs detected in the exhaled breath samples. Receiver operating characteristic curve anal. indicated the sensitivity and specificity to be 96% and 91%, resp. This pilot study demonstrates that FGC eNose is a useful tool to identify VOCs as biomarkers in exhaled breath from COPD patients. Further studies should be performed to enhance the clin. relevance of this quick and ease methodol. for COPD diagnosis.

In some applications, this compound(4221-99-2)Application In Synthesis of (S)-Butan-2-ol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Non-covalently bonded diastereomeric adducts of amino acids and (S)-1-phenylethanol in low-energy dissociative collisions, published in 2020, which mentions a compound: 4221-99-2, Name is (S)-Butan-2-ol, Molecular C4H10O, Formula: C4H10O.

We have studied the collision induced dissociation reactions of proton-bound diastereomeric adducts of S-1-phenylethanol and enantiomers of three different amino acids (tryptophan, phenylalanine, methionine). In all cases, the loss of S-1-phenylethanol from the adduct ion is the only observed process, and the relative abundance is found to be independent of the chirality of the amino acid. This is in contrast to earlier experiments on the dissociation of protonated tryptophan-2-butanol adducts, where chirality affected the results. Results obtained from quantum chem. computations support and provide a rationale for the exptl. observations and highlight temperature as a possible factor of importance for the chiral effect in these types of systems.

In some applications, this compound(4221-99-2)Formula: C4H10O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem