Category: 4221-99-2

Application In Synthesis of (S)-Butan-2-ol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Decarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)-Boron Lewis Acid Catalysis.

Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochem. or electrochem. methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in mols. Herein, Author report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF3. The synthetic utility of decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical mols. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic anal. and control experiments suggest two mechanistic pathways.

This compound((S)-Butan-2-ol)Application In Synthesis of (S)-Butan-2-ol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 4221-99-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Tunable Cis-Cisoid Helical Conformation of Poly(3,5-disubstibuted phenylacetylene)s Stabilized by n→π* Interaction. Author is Wang, Sheng; Cai, Si-Liang; Zhang, Jie; Wan, Xin-Hua.

A series of novel cis poly(phenylacetylene)s (PPAs) substituted at meta-position(s) by two alkoxycarbonyl pendants, i.e., sP-Me-C8/rP-Me-C8, P-Me-C12, sP-Et-C4, sP-2C4 and sP-Oct-C4, were synthesized under the catalysis of [Rh(nbd)Cl]2. The dependence of elongation, screw sense, and stimuli response of helical polyene backbone on the structure of pendant, solvent, and temperature was systematically investigated in both solution and solid states. Because of n→π* interaction between vicinal carbonyl groups, sP-Me-C8/rP-Me-C8 could adopt contracted cis-cisoid helix in THF, toluene, CH2Cl2, and CHCl3. In poly(3-methoxycarbonyl-5-alkoxycarbonylphenylacetylene), the longer the chiral alkyl chain was, the easier the stable cis-cisoid helix could be achieved. However, when the methoxycarbonyl was changed to ethoxycarbonyl, sec-butyloxycarbonyl, and octyloxycarbonyl pendant groups, only cis-transoid helix was obtained at room temperature due to the increased steric hindrance. Moreover, lowering temperature was found to facilitate the stabilization of n→π* interactions, and reversible temperature-dependent stereomutations were achieved in sP-Me-C8 and sP-Et-C4 depending on the solvent where they were dissolved. These results suggested that the long alkyl chain, small pendant size, and lower temperature favored the stabilization of intramol. n→π* interactions and the formation of contracted, cis-cisoid helixes for poly(3,5-diester substituted phenylacetylene)s.

《Tunable Cis-Cisoid Helical Conformation of Poly(3,5-disubstibuted phenylacetylene)s Stabilized by n→π* Interaction》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-Butan-2-ol)Recommanded Product: 4221-99-2.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Butan-2-ol( cas:4221-99-2 ) is researched.Safety of (S)-Butan-2-ol.Saito, Ryo; Sennari, Goh; Nakajima, Asuka; Kimishima, Aoi; Iwatsuki, Masato; Ishiyama, Aki; Hokari, Rei; Hirose, Tomoyasu; Sunazuka, Toshiaki published the article 《Discoveries and syntheses of highly potent antimalarial troponoids》 about this compound( cas:4221-99-2 ) in Chemical & Pharmaceutical Bulletin. Keywords: troponoid preparation antimalarial activity. Let’s learn more about this compound (cas:4221-99-2).

Novel derivatives of puberulic acid were synthesized as RC(O)OR1 (R = 3,4,6-trihydroxy-5-oxocyclohepta-1,3,6-trien-1-yl, 3,4,6-tris(benzyloxy)-5-oxocyclohepta-1,3,6-trien-1-yl; R1 = Me, cyclopentyl, thian-4-yl, etc.), RC(O)N(CH3)R2 (R2 = Me, i-Pr), RC(O)R3 (R3 = Me, cyclohexyl Me, pentane-3-yl Me, etc.) and their antimalarial properties were evaluated in vitro against the Plasmodium falciparum K1 parasite strain, cytotoxicity was evaluated against a human diploid embryonic cell line MRC-5, and in vivo efficacy was evaluated using a Plasmodium berghei-infected mouse model. Based on the previous information the three hydroxy groups on the tropone framework, which were essential for antimalarial activity, were used to convert the carboxylic acid moiety into the corresponding esters, amides, and ketones. These derivatives showed antimalarial activity against chloroquine-resistant Plasmodium in vitro equivalent to puberulic acid. The pentane-3-yl ester, cyclohexyl ester, iso-Bu ketone, and cyclohexyl Me ketone all show an especially potent antiparasitic effect in vivo at an oral dose of 15 mg/kg without any apparent toxicity. These esters were more effective than the existing commonly used antimalarial drug, artesunate.

Different reactions of this compound((S)-Butan-2-ol)Safety of (S)-Butan-2-ol require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Guo, Yongxian; Wu, Aoli; Qiu, Changkun; Ge, Fayuan; Jiang, Yifei; Gong, Yanjun; Hu, Qiongzheng published an article about the compound: (S)-Butan-2-ol( cas:4221-99-2,SMILESS:C[C@H](O)CC ).Reference of (S)-Butan-2-ol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4221-99-2) through the article.

Multicolor luminescent segmented materials have attracted tremendous research interest due to their potential applications as barcoding materials in information security and anti-counterfeiting. Although much effort has been devoted to the preparation of photonic barcodes based on different light-emitting materials, the rational design of barcoding materials with well-controlled emission color and length at desired position remains a challenge. Here, a novel strategy to fabricate multicolor luminescent segmented 1D mol. crystals is reported by manipulating the mol. conformation and intermol. interactions of the mechanochromic crystals, which are assembled from a rationally designed twisting conjugated mol. The emission color of these mechanochromic crystals changes from green to orange with the mechanism of synergy effect of force-induced mol. isomerization from trans to cis state and mol. packing changes from cross to parallel, which is revealed by single crystal X-ray diffraction. Multicolor luminescent segmented 1D microribbons are fabricated by applying precisely controlled forces by tapping mode at. force microscope, which shows the encoding capability. These findings provide a new method that allows the controllable fabrication of segmented materials with tunable emission color and length at desired position toward barcoding applications.

Different reactions of this compound((S)-Butan-2-ol)Reference of (S)-Butan-2-ol require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 4221-99-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Stability Tuning of Vapor-Adsorbed State of Vapochromic Pt(II) Complex by Introduction of Chiral Moiety. Author is Shigeta, Yasuhiro; Kobayashi, Atsushi; Yoshida, Masaki; Kato, Masako.

New luminescent Pt(II) complexes with chiral ester chains, [PtCl2(R,R-bpybe)] (R-1; bpybe = 2,2′-bipyridine-4,4′-dicarboxylic acid di-Bu ester) and its racemic mixture (rac-1) with the chiral isomer, S-1, were synthesized, and their vapochromic behavior was investigated. Single-crystal x-ray structural anal. revealed that the rac-1 crystal was composed of only one crystallog. independent column formed by alternating stacking of R-1 and S-1 by the effective intermol. Pt···Pt interaction. In contrast, three types of columnar structures with different Pt···Pt interactions were found for the R-1 crystal, probably because of the different packing of the chiral ester chains between the columns. Consequently, the estimated mol. volume of R-1 was slightly larger than that in the racemic crystal rac-1, although they have the same chem. formula. The x-ray structure of the toluene-adsorbed rac-1 (rac-1·toluene) also indicated that the intermol. Pt···Pt interaction, which was effective for unsolvated rac-1, was completely canceled out by adsorption of toluene vapor. Both the rac-1 and R-1 crystals exhibited similar vapochromism driven by toluene vapor adsorption/desorption that switched the emission origin between the strongly emissive 3MMLCT (metal-metal-to-ligand charge transfer) to the weakly emissive 3π-π* phosphorescence. Although both crystals had the same chem. formula, the toluene vapor desorption temperature of R-1·toluene (84°) was obviously lower than that of rac-1·toluene (107°), suggesting that the binding interaction with toluene mols. was weaker in R-1·toluene than in rac-1·toluene.

Different reactions of this compound((S)-Butan-2-ol)Related Products of 4221-99-2 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-Butan-2-ol(SMILESS: C[C@H](O)CC,cas:4221-99-2) is researched.Safety of 2-Amino-5-chlorobenzaldehyde. The article 《Interfacial acidity on oxide surfaces: a scaling paradigm and the role of the hydrogen bond》 in relation to this compound, is published in ChemRxiv. Let’s take a look at the latest research on this compound (cas:4221-99-2).

A fundamental understanding of acidity at an interface, as mediated by structure and mol.-surface interactions, is essential to elucidate the mechanisms of a range of chem. transformations. While the strength of an acid in the gas and solution phases is conceptually well understood, how acid-base chem. works at an interface is notoriously more complicated. Using d. functional theory and nonlinear vibrational spectroscopy, we have developed a method to determine the interfacial Bronsted-Lowry acidity of aliphatic alcs. adsorbed on the {100} surface of the model perovskite, strontium titanate. Here we show that, while shorter and less branched alkanols are less acidic as a gas and more acidic in solution, shorter alcs. are less acidic whereas less substituted alkanols are more acidic at the gas-surface interface. Hydrogen bonding plays a critical role in defining acidity, whereas structure-acidity relationships are dominated by van der Waals interactions between the alc. and the surface.

After consulting a lot of data, we found that this compound(4221-99-2)Related Products of 4221-99-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Butan-2-ol( cas:4221-99-2 ) is researched.Category: tetrahydrofurans.Kilic, Ahmet; Balci, Tugba Ersayan; Arslan, Nevin; Aydemir, Murat; Durap, Feyyaz; Okumus, Veysi; Tekin, Recep published the article 《Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation》 about this compound( cas:4221-99-2 ) in Applied Organometallic Chemistry. Keywords: diol chiral ligand dioxaborinane preparation radical scavenging antibacterial; reducing power DNA binding cleavage diol chiral ligand dioxaborinane; chiral stereoselective transfer hydrogenation ketone diol chiral ligand dioxaborinane. Let’s learn more about this compound (cas:4221-99-2).

Two cis-1,2-diol-type chiral ligands (T1 and T2) and their tri-coordinated chiral dioxaborinane (T(1-2)B(1-2)) and four-coordinated chiral dioxaborinane adducts with 4-tert-Bu pyridine sustained by N → B dative bonds (T(1-2)B(1-2)-N) were synthesized and characterized by various spectroscopic techniques such as NMR (1H, 13C, and 11B), FT-IR and UV-Vis spectroscopy, LC-MS/MS, and elemental anal. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biol. studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermol. interactions. To assess the biol. activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asym. transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.

After consulting a lot of data, we found that this compound(4221-99-2)Category: tetrahydrofurans can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kemper, Michael; Engelage, Elric; Merten, Christian published an article about the compound: (S)-Butan-2-ol( cas:4221-99-2,SMILESS:C[C@H](O)CC ).Electric Literature of C4H10O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4221-99-2) through the article.

Chiral mol. propeller conformations have been induced to various triaryl structures including trityl derivatives and triaryl boranes. For borane-amine adducts, such induced propeller chirality has not been reported yet due to the low energy barrier for racemization in common triarylboranes such as B(C6H5)3 or B(C6F5)3. Herein, we demonstrate that point chirality in side chains of chiral triarylborane-ammonia adducts, which feature intramol. hydrogen bonds in addition to the dative N→B bond, can efficiently be transferred to triarylborane propeller chirality. Employing X-ray crystallog. and ECD/VCD spectroscopy for structural characterizations, we investigate three examples with different steric demands of the incorporated chiral alkoxy side groups. We elucidate the conformational preferences of the mol. propellers. Furthermore, we show that computationally predicted conformational preferences obtained for the isolated, only implicitly solvated mols. are actually opposite to the exptl. observed ones.

After consulting a lot of data, we found that this compound(4221-99-2)Electric Literature of C4H10O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Recognition in Chiral Ionic Liquids: The Achiral Cation Makes the Difference!, Author is Blasius, Jan; Zaby, Paul; Holloczki, Oldamur; Kirchner, Barbara, which mentions a compound: 4221-99-2, SMILESS is C[C@H](O)CC, Molecular C4H10O, COA of Formula: C4H10O.

By simulating butan-2-ol dissolved in the chiral ionic liquid 1-ethyl-3-methylimidazolium (S)-alaninate, we investigate the chiral recognition of butan-2-ol in the ionic liquid The hydrogen bonding between the chiral anion and both enantiomers of butan-2-ol is similar; however, both chiral mols. (anion and alc.) induce an asymmetry in the achiral cation which leads to a more favorable environment for the alc. in the heterochiral system as compared to the homochiral system and hence provides an energetic stabilization of the former.

After consulting a lot of data, we found that this compound(4221-99-2)COA of Formula: C4H10O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 4221-99-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Visible-Light-Mediated C-I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator. Author is Yue, Fuyang; Dong, Jianyang; Liu, Yuxiu; Wang, Qingmin.

Herein, a protocol for direct visible-light-mediated C-I difluoroallylation reactions of α-trifluoromethyl arylalkenes RC(=CH2)CF3 [R = 4-(benzyloxy)phenyl, 3,4,5-trimethoxyphenyl, naphthalen-2-yl, etc.] with alkyl iodides R1I (R1 = Et, cyclohexyl, oxetan-3-yl, etc.) at room temperature with an α-aminoalkyl radical as a mediator was reported. The protocol permits efficient functionalization of various α-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.

Although many compounds look similar to this compound(4221-99-2)Recommanded Product: 4221-99-2, numerous studies have shown that this compound(SMILES:C[C@H](O)CC), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem