Simple exploration of 3-Methyldihydrofuran-2,5-dione

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A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors from TE85 osteosarcoma cells but > 1 muM binding affinity to the progesterone receptors from T47D and ZR75 human breast carcinpma cells.Structure-activity relationships were developed for a set of these compounds, and a representative analog 1-(3,4-dichlorobenzoyl)-3-phenyl-1,4,5,6-tetrahydropyridazine (1i, RWJ 25333) was chosen for further evaluation.RWJ 25333 stimulated the in vitro proliferation of human osteoblast-like cells but not human breast cells.

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Referenceï¼?br>Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Compounds of the formula I in which A-B, X, R 1 and R2 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and are suitable for the prophylaxis or treatment of schizophrenia, depression, anxiety states, dementia, Alzheimer’s disease, Lewy bodies dementia, neurodegenerative disorders, Parkinson’s disease, Huntington’s disease, Tourette’s syndrome, learning and memory restrictions, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Compounds of the formula I in which A-B, X, R 1 and R2 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and are suitable for the prophylaxis or treatment of schizophrenia, depression, anxiety states, dementia, Alzheimer’s disease, Lewy bodies dementia, neurodegenerative disorders, Parkinson’s disease, Huntington’s disease, Tourette’s syndrome, learning and memory restrictions, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Reference of 4100-80-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4100-80-5, 3-Methyldihydrofuran-2,5-dione, introducing its new discovery.

17O NMR spectra were recorded for several series of anhydrides (.The 17O NMR data were found to be sensitive to ring size and conformation.Substituent effects on a series of maleic anhydrides could be rationalized in terms of electronic effects.In contrast, the 17O NMR data for polycyclic succinic anhydrides showed that the chemical shifts of the carbonyl oxygens were roughly constant, while those of the central oxygens were sensitive to structure.The 17O NMR data for homophthalic anhydride were consistent with those for 2 and 27; the data for pyridine-2,3-dicarboxylic anhydride could be rationalized in terms of electronic effects, and those for 3,4-dihydronaphthalene-1,2-dicarboxylic anhydride were explained by compressional and electronic effects.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Recent work on the graft polymerization of vinyl monomers to polyolefins and model hydrocarbons is reviewed. For practical reasons, these reactions are performed at high temperatures, typically 160-200 C, with tertiary peroxides such as di-tert-butyl peroxide (DBP) as initiators. Vinyl monomers of particular interest include maleic anhydride, vinyl silanes and methacrylates. These monomers have low ceiling temperatures and are less prone to undergo concurrent homopolymerization at 160-200 C than monomers such as acrylates and styrene which have normal enthalpies of polymerization. Initiation of grafting typically involves hydrogen abstraction from the hydrocarbon/polyolefin by tert-butoxy radicals. At high temperatures, beta-scission of tert-butoxy radicals also occurs to give alkyl radicals which primarily react with monomers to initiate homopolymerization. There are two graft propagation steps – addition of monomer to a hydrocarbon/polyolefin radical, R and hydrogen abstraction by the resulting RM adduct to yield a singly attached monomer unit and a new R type radical. It is argued that the otherwise slow hydrogen abstraction occurs readily in these grafting systems for two reasons. One is the high temperature, which favors the process of higher activation energy. The second is intramolecular hydrogen abstraction with linear and branched hydrocarbons. The grafting of a number of vinyl monomers to hydrocarbon substrates is described in terms of the proposed mechanisms. The recently developed application of living free radical polymerization to the preparation of block copolymers is discussed. At temperatures above 100 C, polymer radical-nitroxide complexes partly dissociate thus enabling addition of the same or a different vinyl monomer. Some recent applications are described.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 3-Methyldihydrofuran-2,5-dione

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A synthetic route to 4-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one (2), a valuable synthon to etretinate (1), a potent antipsoriatic drug is described.The keto acids (3a) and (3b) obtained from 2,5-dimethylanisole by acylation with methylsuccinic and succinic anhydrides, respectively are elaborated separately to the identical methoxytrimethyldihydronaphthalene (7a) which on ozonolysis furnishes the ring opened arylketoaldehyde (8).Strategic manipulation of the keto and aldehyde functions of 8 leads to the arylbutanone (14).Side chain bromination of 14 gives the bromoketone (15) which provides on dehydrobromination the key synthon (2).

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Tetrahydrofuran – Wikipedia,
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A variety of trans-6-[2-(substituted-1-naphthyl)ethyl(or ethyl)]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones were prepared and, upon conversion to their 3,5-dihydroxy carboxylates, were found to have good inhibitory activity against the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-determining enzyme in cholesterogenesis. The most active compounds are 2,4,6- and 2,4,7-trichloro derivatives and would be expected to display about the same potency as the standard compactin (1a) upon resolution.

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Tetrahydrofuran – Wikipedia,
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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4100-80-5, name is 3-Methyldihydrofuran-2,5-dione, introducing its new discovery. SDS of cas: 4100-80-5

The zeolite-catalysed acylation of anisole with methylsuccinic anhydride gave a mixture of products. The main component was 4-hydroxy-4,4-bis-(4-methoxyphenyl)-2-methyl-gamma-butyrolactone, which was isolated in 25% yield; the expected keto acids were not formed. In the zeolite-catalysed reaction between 3-(4-methoxybenzoyl)-2-methylpropionic acid and anisole, the gamma-butyrolactone was isolated in 82% yield, indicating that the initially formed keto acid undergoes cyclisation to the lactone. When these reactions were performed with a zeolite deactivated with triphenylphosphine, the lactone was not formed, suggesting that acid sites on the external surface of the zeolite catalyse these reactions. Acta Chemica Scandinavica 1997.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Lithium trialkylborohydrides reduce cyclic anhydrides to the corresponding lactones in good to excellent isolated yields.With unsymmetrical anhydrides, increasing the steric requirements of the trialkylborohydride dramatically enhances the regioselectivity of the reduction of the less hindered carbonyl group of the anhydride.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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A novel methodology based on fluorescence quenching measurements is introduced to determine quantitatively the amine content of polyisobutylene succinimide (PIBSI) dispersants used as engine oil-additives. To this end, a series of five PIBSI dispersants were prepared by reacting 2 mol equiv of polyisobutylene succinic anhydride (PIBSA) with 1 mol equiv of hexamethylenediamine (HMDA), diethylenetriamine, triethylenetetramine, tetraethylenepentamine, and pentaethylenehexamine to yield the corresponding b-PIBSI dispersants. After having demonstrated that the presence of hydrogen bonds between the polyamine linker and the succinimide carbonyls of the dispersants prevents the quantitative analysis of the 1H NMR and FTIR spectra of the dispersants to determine their chemical composition, alternative procedures based on gel permeation chromatography (GPC) and fluorescence quenching were implemented to estimate the amine content of the b-PIBSI dispersants. Taking advantage of the doubling in size that occurs when 2 mol of PIBSA are reacted with 1 mol of HMDA, a combination of GPC and FTIR was employed to follow how the chemical composition and molecular weight distribution of the polymers produced evolved with the reaction of PIBSA and HMDA mixed at different molar ratios. These experiments provided the PIBSA-to-HMDA molar ratio yielding the largest b-PIBSI dispersants and this molar ratio was then selected to prepare the four other dispersants. Having prepared five b-PIBSI dispersants with well-defined secondary amine content, the fluorescence of the succinimide groups was found to decrease with increasing number of secondary amines present in the polyamine linker. This result suggests that fluorescence quenching provides a valid method to determine the chemical composition of b-PIBSI dispersants which is otherwise difficult to characterize by standard 1H NMR and FTIR spectroscopies. A 2014 American Chemical Society.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem