Category: 3066-84-0

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Regulation of One-Electron Oxidation Rate of Guanine by Base Pairing with Cytosine Derivatives, published in 2002-04-10, which mentions a compound: 3066-84-0, Name is 8-Bromoguanine, Molecular C5H4BrN5O, Category: tetrahydrofurans.

Effects of base pairing on the one-electron oxidation rate of guanine derivatives, guanine, 8-bromoguanine, and 8-oxo-7,8-dihydroguanine have been studied. The one-electron oxidation rate of guanine derivatives was determined by triplet-quenching experiments, using N,N’-dibutylnaphthaldiimide (NDI) in the triplet excited state (3NDI*) and fullerene (C60) in the triplet excited state (3C60*) as oxidants. In all three guanine derivatives studied here, acceleration of the one-electron oxidation was observed upon hydrogen bonding with cytosine, which demonstrates lowering of the oxidation potential of guanine derivatives by base pairing with cytosine. When a Me or bromo group was introduced to the C5 position of cytosine, acceleration or suppression of the one-electron oxidation relative to the guanine:cytosine base pair was observed, resp. The results demonstrate that the one-electron oxidation rate of guanine in DNA can be regulated by introducing a substituent on base pairing cytosine.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Oxidation of guanine and guanosine by bromine》. Authors are Shapiro, Robert; Agarwal, Satish C..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).HPLC of Formula: 3066-84-0. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

In order to establish the chem. basis for the mutagenic effect of brominating agents, guanine (I) and guanosine (II) were subjected to the action of Br, and the reaction products were investigated. Treatment of I with excess Br in H2O at room temperature for several days afforded 38% oxalylguanidine (III), m. >300°. Alternate routes to III were: (1) CrO3 oxidation of 2amino-4,6-dihydroxypyrimidine, or (2) condensation of EtO2CCO2Et with H2NC(NH2): NH.H2CO3. The latter reaction also yielded oxalylbiguanide (IV), m. 232-4°. In addition to III, the following degradation products were formed from I upon reaction with Br (method of isolation and percent yield given): oxaluric acid (NH4+ salt, 32); guanidine (picrate, 26); and oxalic acid (Ca++ salt, 24). The presence of urea was also demonstrated chromatographically and estimated spectrophotometrically. Reaction of I with Br in a limited amount of H2O gave rise to 8-bromoguanine, from which the same degradation products were produced upon further treatment with aqueous Br. When II was allowed to react with excess Br in H2O the initial product (65% yield) was identified as 8-bromoguanosine (V). Upon further reaction, V was degraded to the following products: oxalic acid, guanidine, urea, ribose, D-ribosylurea, and D-ribosyloxaluric acid. Paper chromatography and electrophoresis were used for the separation and identification of these products. The mutagenic action of Br is attributed to destruction of the guanine residues in nucleic acids. The loss of guanine would result in disruption of H bonds and a weakening of the secondary structure of the nucleic acid chains.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reaction of guanine with glycidol, published in 2009-02-28, which mentions a compound: 3066-84-0, Name is 8-Bromoguanine, Molecular C5H4BrN5O, Quality Control of 8-Bromoguanine.

Reaction of guanine with glycidol regiospecifically gave 2-amino-6-oxo-9-(2,3-dihydroxypropyl)purine. Reaction of 8-bromoguanine with glycidol gave a mixture of 2-amino-6-oxo-8-bromo-3- and 9-(2,3-dihydroxypropyl)purine.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Low spin ferric hemoglobin complexes》. Authors are Harris, Gilda.The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Electric Literature of C5H4BrN5O. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

A calculation has been made of the energy eigenfunctions and eigenvalues of low-spin ferric ion in complexes with a strong cubic crystal field including the effects of tetragonal and rhombic distortions and of spin-orbit coupling among the ground state components and with excited states. Using the resultant, spin-orbit coupled eigenfunctions as a basis set, the magnetic susceptibility, the components of magnetic field energy, and the lattice and valence contributions to an elec. field gradient at the iron nucleus were all calculated as a function of rhombic, tetragonal, and spin-orbit coupling strength used as parameters: R, u, and δ. All of the calculated results agree reasonably well with exptl. for the values of parameters R = 1000 cm.-1 u = 2000 cm.-1, and the free ion value δ= 420 cm.-1 These values of parameters were selected for the excellent fit they gave of the calculated values of gx, gy, and gz compared with the exptl. ones obtained from single crystal ESR of ferriHb azide. With them, a value of 2.29 μB was calculated for the effective magnetic moment compared to the exptl. value of 2.35. The total field gradient calculated under the same conditions predicts a nuclear quadrupole moment Q in the range of 0.107-0.127 barns, which is smaller than the range predicted from the high spin ferric ion results. Reasons for the discrepancy are discussed. 16 references

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3066-84-0, is researched, Molecular C5H4BrN5O, about Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase, the main research direction is oxoguanine DNA glycosylase substrate recognition cleavage kinetics.Reference of 8-Bromoguanine.

Human 8-oxoguanine-DNA glycosylase (hOgg1) excises 8-oxo-7,8-dihydroguanine (8-oxoG) from damaged DNA. The authors report a pre-steady-state kinetic anal. of hOgg1 mechanism using stopped-flow and enzyme fluorescence monitoring. The kinetic scheme for hOgg1 processing an 8-oxoG:C-containing substrate was found to include at least three fast equilibrium steps followed by two slow, irreversible steps and another equilibrium step. The second irreversible step was rate-limiting overall. By comparing data from Ogg1 intrinsic fluorescence traces and from accumulation of products of different types, the irreversible steps were attributed to two main chem. steps of the Ogg1-catalyzed reaction: cleavage of the N-glycosidic bond of the damaged nucleotide and β-elimination of its 3′-phosphate. The fast equilibrium steps were attributed to enzyme conformational changes during the recognition of 8-oxoG, and the final equilibrium, to binding of the reaction product by the enzyme. HOgg1 interacted with a substrate containing an aldehydic AP site very slowly, but the addition of 8-bromoguanine (8-BrG) greatly accelerated the reaction, which was best described by two initial equilibrium steps followed by one irreversible chem. step and a final product release equilibrium step. The irreversible step may correspond to β-elimination since it is the very step facilitated by 8-BrG.

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Tetrahydrofuran – Wikipedia,
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