Category: 3066-84-0

Garel, Jean Pierre; Filliol, Dominique; Mandel, Paul published an article about the compound: 8-Bromoguanine( cas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O ).Application In Synthesis of 8-Bromoguanine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3066-84-0) through the article.

The behavior of 64 nucleic compounds (bases, nucleosides, nucleoside-mono-, -di-, and triphosphates) and 18 amino acids was studied in a saline solvent system used for counter-current distribution of transfer RNA based on 1.50M K phosphate pH 7.0, 2-methoxyethanol and 2-butoxyethanol. From the values of partition isotherms and partition coefficients K, measured in standard conditions at 20° and for 20% 2-butoxyethanol, it can be concluded that: (1) thiolation of bases decreases K, (2) phosphorylation of nucleosides accounts for neg., but additive effect on K, and (3) aliphatic lengthening of amino acids residues, N-alkylation, O-methylation, halogenation, C → N intracyclic substitution of bases, ribose → 3′-deoxyribose transformation increase K. The effect of these base or nucleoside substitutions is discussed and related to the mobility of tRNA separated by counter-current distribution.

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Tetrahydrofuran – Wikipedia,
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Recommanded Product: 3066-84-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Chemically Modified Oligonucleotides.

A variety of chem. modified oligonucleotides was studied by the title method (MALDI-TOFMS) in the neg. ion mode. These include oligonucleotides containing modified bases, such as uracil glycol, bromoguanine, O6-butylguanine, as well as oligonucleotides in which the phosphodiester groups had been replaced by other functional groups, such as phosphorothioates. With the linear TOF mass spectrometer, there is no or very little fragmentation observed, and the determination of the mol. weight by MALDI-TOFMS offers a convenient way for identifying/confirming the presence of the modification. With internal calibration, a mass accuracy of 0.01% can be achieved. Such mass accuracy makes it possible to directly differentiate a small uridine-containing oligonucleotide from its cytidine-containing analog. Because of factors such as sample inhomogeneity, laser output fluctuation, and the dynamic range of the detector, quantitation by MALDI-TOFMS has been difficult. Nevertheless, semiquant. information can be obtained for those analytes that are closely related in structure. Monitoring the products of the synthesis of monophosphorothioated oligoribonucleotide 16-mers by MALDI-TOFMS revealed that the sulfur atom in the phosphorothioate group can be replaced by an oxygen atom during the succeeding introduction of phosphodiester groups. The earlier the phosphorothioate group is introduced during the synthesis of the 16-mer, the greater is the extent of sulfur to oxygen replacement.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Irreversible enzyme inhibitors. LXXIII. Inhibitors of guanine deaminase. 1. Mode of binding of guanine, published in 1967, which mentions a compound: 3066-84-0, mainly applied to GUANINE BINDING GUANINE DEAMINASE; SUBSTRATE BINDING GUANINE DEAMINASE; BINDING GUANINE GUANINE DEAMINASE; GUANINE DEAMINASE GUANINE BINDING, HPLC of Formula: 3066-84-0.

cf. preceding abstract Investigation of guanine and 17 related compounds as substrates or inhibitors of guanine deaminase led to a suggested mode of binding of guanine. The 1- and 9-hydrogens of guanine are probably complexed to the enzyme as electron acceptors and the 6-oxo and 7-nitrogen are complexed as electron donors. It appears that the π cloud, as well as the 2-NH2 group of guanine do not complex to the enzyme. It is possible that the 3-nitrogen of guanine as an electron donor is complexed to the enzyme.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromoguanine( cas:3066-84-0 ) is researched.Application of 3066-84-0.Guerra, Celia Fonseca; van der Wijst, Tushar; Bickelhaupt, F. Matthias published the article 《Substituent Effects on Hydrogen Bonding in Watson-Crick Base Pairs. A Theoretical Study》 about this compound( cas:3066-84-0 ) in Structural Chemistry. Keywords: hydrogen bond Watson Crick nucleic acid base pair; nucleic acid base pair halogen substituent effect hydrogen bond. Let’s learn more about this compound (cas:3066-84-0).

We have theor. analyzed Watson-Crick AT and GC base pairs in which purine C8 and/or pyrimidine C6 positions carry a substituent X = H, F, Cl or Br, using the generalized gradient approximation (GGA) of d. functional theory at BP86/TZ2P. The purpose is to study the effects on structure and hydrogen bond strength if X = H is substituted by a halogen atom. Furthermore, we wish to explore the relative importance of electrostatic attraction vs. orbital interaction in the above multiply hydrogen-bonded systems, using a quant. bond energy decomposition scheme. We find that replacing X = H by a halogen atom has relatively small yet characteristic effects on hydrogen bond lengths, strengths and bonding mechanism. In general, it reduces the hydrogen-bond-accepting- and increases the hydrogen-bond-donating capabilities of a DNA base. The orbital interaction component in these hydrogen bonds is found for all substituents (X = H, F, Cl, and Br) to contribute about 41% of the attractive interactions and is thus of the same order of magnitude as the electrostatic component, which provides the remaining 59% of the attraction.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogenation of nucleic acids. I. Action of bromine on bases and nucleosides in dimethylformamide medium》. Authors are Duval, J.; Ebel, J. P..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Safety of 8-Bromoguanine. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

The reaction of Br2 at 0-50° with the purine and pyrimidine bases and their ribonucleosides dissolved in dimethylformamide completely free of moisture gives 5-bromouracil, 5-bromocytosine, 8-bromoguanine, and their corresponding nucleosides in good yield; but adenine and its nucleosides are not brominated. If a small amount of water is present in the reaction mixture, the reaction proceeds further and dibrominated derivatives are formed which do not show uv absorption.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Excess electron transfer in G-quadruplex, published in 2004, which mentions a compound: 3066-84-0, mainly applied to electron transfer guanine bromoguanine DNA, Reference of 8-Bromoguanine.

The excess electron transfer in a G-quadruplex is successfully probed by using the reaction of hydrated electrons with quadruplex complex of pentamers and the 8-bromoguanine moieties as the detection system.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromoguanine( cas:3066-84-0 ) is researched.Computed Properties of C5H4BrN5O.Olaru, Niculae; Simon, Zeno published the article 《Electronic structure and reactivity indexes for a series of purine derivatives, inhibitors of guanine phosphoribosyltransferase from Escherichia coli》 about this compound( cas:3066-84-0 ) in Revue Roumaine de Chimie. Keywords: structure activity purine derivative guanine phosphoribosyltransferase; Escherichia guanine phosphoribosyltransferase inhibition purine structure; electron structure purine guanine transferase inhibition. Let’s learn more about this compound (cas:3066-84-0).

The reactivity indexes and electronic structure for a series of 62 purinic derivatives, tested as inhibitors of guanine phosphoribosyltransferase (GPRT) from E. coli, were calculated using HMO and Del Re methods. Some quant. structure activity relationships (QSAR) for a set of 13 compounds with similar steric structure are given. The correlational equations obtained show the importance of electronic control in the inhibition of GPRT.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3066-84-0, is researched, Molecular C5H4BrN5O, about Effect of Different Z-Inducers on the Stabilization of Z Portion in BZ-DNA Sequence: Correlation Between Experimental and Simulation Data, the main research direction is B Z DNA conformation free energy mol dynamics simulation; B-Z junction; DNA; chirality index; circular dichroism; free energy calculation.Quality Control of 8-Bromoguanine.

In this study we show the outstanding agreement between simulation and exptl. data concerning the efficient stabilization effect by NaCl of Z conformation. We demonstrate by CD (CD) experiments that Na+ not only is able to induce a B to Z form transition in a short (GC)3 alternated portion of a sequence having 17 basis, but also is the best stabilizer in comparison with other Z inducers used (spermine and NiCl2). This result was confirmed by free energy calculations

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Tetrahydrofuran – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Inhibition profile of Leishmania mexicana arginase reveals differences with human arginase I, published in 2011-04-30, which mentions a compound: 3066-84-0, mainly applied to Leishmania arginase inhibition, Application In Synthesis of 8-Bromoguanine.

Arginase (ARG), the enzyme that catalyzes the conversion of arginine to ornithine and urea, is the first and committed step in polyamine biosynthesis in Leishmania. The creation of a conditionally lethal Δarg null mutant in Leishmania mexicana has established that ARG is an essential enzyme for the promastigote form of the parasite and that the enzyme provides an important defense mechanism for parasite survival in the eukaryotic host. Furthermore, human ARGI (HsARGI) has also been implicated as a key factor in parasite proliferation. Thus, inhibitors of ARG offer a rational paradigm for drug design. To initiate a search for inhibitors of the L. mexicana ARG (LmARG), recombinant LmARG and HsARGI enzymes were purified from Escherichia coli. Both LmARG and HsARGI were specific for L-arginine and exhibited no activity with either D-arginine or agmatine as possible substrates. LmARG exhibited a Km of 25 ± 4 mM for L-arginine, a pH optimum ∼9.0, and was dependent upon the presence of a divalent cation, preferentially manganese. A Km of 13.5 ± 2 mM for L-arginine was calculated for the HsARGI. A collection of 37 compounds was evaluated against both enzymes. Twelve of these compounds were identified as being either strong inhibitors of both LmARG and HsARGI or differential inhibitors between the two enzymes. Of the 12 compounds, six were selected for further anal. and the type and extent of inhibition determined

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromoguanine(SMILESS: NC(N1)=NC(NC(Br)=N2)=C2C1=O,cas:3066-84-0) is researched.Electric Literature of C10H10Cl2N2Pt. The article 《Effects of Site-Specific Guanine C8-Modifications on an Intramolecular DNA G-Quadruplex》 in relation to this compound, is published in Biophysical Journal. Let’s take a look at the latest research on this compound (cas:3066-84-0).

Understanding the fundamentals of G-quadruplex formation is important both for targeting G-quadruplexes formed by natural sequences and for engineering new G-quadruplexes with desired properties. Using a combination of exptl. and computational techniques, we have investigated the effects of site-specific substitution of a guanine with C8-modified guanine derivatives, including 8-bromo-guanine, 8-O-methyl-guanine, 8-amino-guanine, and 8-oxo-guanine, within a well-defined (3+1) human telomeric G-quadruplex platform. The effects of substitutions on the stability of the G-quadruplex were found to depend on the type and position of the modification among different guanines in the structure. An interesting modification-dependent NMR chem.-shift effect was observed across basepairing within a guanine tetrad. This effect was reproduced by ab initio quantum mech. computations, which showed that the observed variation in imino proton chem. shift is largely influenced by changes in hydrogen-bond geometry within the guanine tetrad.

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