Category: 3066-84-0

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about The new models of the human telomere DNA in K+ solution revealed by NMR analysis assisted by the incorporation of 8-bromoguanines, the main research direction is model human telomere DNA bromoguanine potassium.Reference of 8-Bromoguanine.

The structure of human telomeric DNA has been controversial: the solution structure in the presence of Na+ has been reported to be antiparallel basket-type quadruplex by NMR, while the crystal structure in the presence of K+ has been reported to be parallel propeller-type quadruplex. The solution structure in the presence of K+ has drawn intense interest, as the intracellular K+ concentration is higher than that of Na+, but the structure is still open to address. Recently Sugiyama et al. has suggested that the DNA exists as a mixture of mixed-parallel/antiparallel quadruplex and antiparallel chair-type quadruplex on the basis of the combination of a series of 8-bromoguanine mutations and CD anal. Here, we have started NMR anal. of the DNAs with the mutations to evaluate the proposed model. So far, NMR anal. is qual. consistent with the proposal. The structure determination is in progress to evaluate the model at at. resolution

In addition to the literature in the link below, there is a lot of literature about this compound(8-Bromoguanine)Reference of 8-Bromoguanine, illustrating the importance and wide applicability of this compound(3066-84-0).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Physical changes and mutagenesis》. Authors are Setlow, R. B..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Recommanded Product: 8-Bromoguanine. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

Uv (280 mμ) irradiation of DNA in vitro and in vivo results in dimerization of adjacent thymines in the same polynucleotide chain. These dimers are split by short wave uv (240 mμ) and by enzymic action plus visible light. In either case the decrease in the number of dimers is correlated with the increase in the biol. activity of DNA or increase in colony-forming ability of irradiated cells. In an in vitro polymerase system there was slow polymerization around thymine dimers, the product was deficient in adenine, and the base composition was not complementary to the irradiated primer. In Escherichia coli the dimers were removed from the DNA in the form of small oligonucleotides.

In addition to the literature in the link below, there is a lot of literature about this compound(8-Bromoguanine)Recommanded Product: 8-Bromoguanine, illustrating the importance and wide applicability of this compound(3066-84-0).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The role of purine and pyrimidine bases and their analogs in radiation sensitivity》. Authors are Kaplan, Henry S.; Earle, John D.; Howsden, F. L..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Category: tetrahydrofurans. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

A high guanine and cytosine content confers increased sensitivity of DNA to x-rays and mustards and increased resistance to uv light. Purine or thymine starvation or incubation with some purine and pyrimidine analogs may alter bacterial responsiveness to radiation. Possible mol. mechanisms of radiosensitization phenomena are reviewed.

In addition to the literature in the link below, there is a lot of literature about this compound(8-Bromoguanine)Category: tetrahydrofurans, illustrating the importance and wide applicability of this compound(3066-84-0).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Negative chemical ionization mass spectrometry of nucleosides, published in 1983-09-30, which mentions a compound: 3066-84-0, Name is 8-Bromoguanine, Molecular C5H4BrN5O, Application In Synthesis of 8-Bromoguanine.

The title study, using H2/N2O mixed gas reagent, showed that each base fragment ion [b]- peak was strong, that the [m-H]- peak was weak or nonexistent, and that a significant [b + O]- ion was present. The formation of this latter in correlates with the LUMO energy of the corresponding base. A group of low mass ions, due to sugar moiety cleavages, was observed for ribonucleosides but not in 2′-deoxyribonucleosides. The neg. chem. ionization spectra of halonucleosides had prominent (often base peaks) halogen ion peaks; M- was always formed from these compounds The mechanism of neg ion production from nucleosides was discussed.

In addition to the literature in the link below, there is a lot of literature about this compound(8-Bromoguanine)Application In Synthesis of 8-Bromoguanine, illustrating the importance and wide applicability of this compound(3066-84-0).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

SDS of cas: 3066-84-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Quantitative analysis of single-molecule FRET signals and its application to telomere DNA. Author is Okamoto, Kenji; Terazima, Masahide.

Quant. anal. of single-mol. FRET signals and its application to telomere DNA was examined This chapter initially describes a definition of the FRET efficiency, followed by the exptl. methods for accurate determination of the efficiency. The method based on the cumulative distribution function (CDF) style plots is explained with a comparison with the traditional methods. Some advances in FRET measurements are described and an example using the CDF method to determine the conformation of telomere DNA is presented.

There are many compounds similar to this compound(3066-84-0)SDS of cas: 3066-84-0. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C5H4BrN5O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Complex sequence dependence by excess-electron transfer through DNA with different strength electron acceptors. Author is Manetto, Antonio; Breeger, Sascha; Chatgilialoglu, Chryssostomos; Carell, Thomas.

An independent jump: Excess electrons move through DNA by using a hopping-type mechanism in which the pyrimidine bases dT and dC act as ‘stepping stones’. It was shown that GC base pairs, in contrast to AT base pairs, lower the efficiency of the excess-electron transfer through the duplex. Through the use of the shown DNA hairpins, three different electron acceptors (□) were investigated with the electron donor, reduced flavin (character omitted).

There are many compounds similar to this compound(3066-84-0)Computed Properties of C5H4BrN5O. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogenation of nuclei acids. II. Bromination of yeast ribonucleic acids in dimethylformamide solution》. Authors are Duval, J.; Ebel, J. P..The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Formula: C5H4BrN5O. Through the article, more information about this compound (cas:3066-84-0) is conveyed.

cf. CA 62, 6716b. The reaction of Br2 on the RNA’s dissolved in moisture-free dimethylformamide (I) as quaternary ammonium salts produces mainly 8-bromoguanine, 5-bromouracil, and 5-bromocytosine. Adenine is not brominated. A secondary reaction takes place, mainly with guanine, leading to formation of compounds having lost their uv absorption. In the ease of the soluble RNA, bromination in I leaves the polynucleotide chain intact, but an alteration of the secondary structure occurs; this alteration increases with the degree of bromination. In the case of ribosomal RNA, the treatment causes a progressive decrease of the sedimentation constants of both the 26S and 16S components. The reasons for the difference in behavior of soluble RNA and ribosomal RNA toward bromination are discussed. 38 references.

There are many compounds similar to this compound(3066-84-0)Formula: C5H4BrN5O. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C5H4BrN5O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Electronic spectra of adenine and guanine: assignments and effects of solution environment. Author is Santhosh, C.; Mishra, P. C..

The results obtained on the UV absorption and fluorescence spectra of adenine and guanine and partially those of 8-azaguanine and 8-bromoguanine are discussed and interpreted with the help of MO calculations Effects of oxygenation and nitrogenation on the spectra and possible tautomerizations of mols. induced by oxygen and UV irradiation have mainly been the subjects of interest. Oscillations observed in the absorption spectra of guanine in aqueous solutions under UV irradiation are interpreted in terms of the tautomerism of the mol. following its slow complexation with the dissolved oxygen. This complexation of oxygen with guanine in DNA may cause lethal damage to biol. systems including carcinogenesis.

There are many compounds similar to this compound(3066-84-0)Synthetic Route of C5H4BrN5O. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about A study of the interactions that stabilize DNA frayed wires.Category: tetrahydrofurans.

Oligodeoxyribonucleotides (ODNs) with long, terminal runs of consecutive guanines, and either a dA or dT tract at the other end form higher-order structures called DNA frayed wires. These aggregates self-assemble into species consisting of 2, 3, 4, 5, … associated strands. Some of the remarkable features of these structures are their extreme thermostability and resistance to chem. denaturants and nucleases. However, the nature of the mol. interactions that stabilize these structures remains unclear. Based on di-Me sulfate (DMS) methylation results, our group previously proposed DNA frayed wires to be a unique set of nucleic-acid assemblies in which the N7 of guanine does not participate in the guanine-guanine interactions. To probe the hydrogen bonding involved in the stabilization of d(A15G15) frayed wires, we used Raman spectroscopy in which the DNA sample is held in photonic crystal fibers. This technique significantly enhances the signals thus allowing the use of very low laser power. Based on our results for d(A15G15) and those of incorporating the isoelectronic guanine analog pyrazolo[3,4,-d]pyrimidine or PPG, into a frayed wire-forming sequence, we provide evidence that these structures are based on the G-quadruplex model. Furthermore, from the Raman spectrum, we observed markers that are consistent with the presence of deoxyguanosine residues in the syn conformation, this suggests the presence of anti-parallel G-quadruplexes. To identify the species that contain syn guanine residues, we used CD and gel electrophoresis to study an ODN in which all of the guanine residues were brominated, d(A15 8-BrG15). In the presence of potassium, d(A15 8-BrG15) forms what appears to be an anti-parallel dimeric G-quadruplex. To our knowledge, this is the first report of a DNA sequence having all its guanine residues replaced by 8-bromo-guanine and maintaining its ability to form a G-quadruplex structure.

There are many compounds similar to this compound(3066-84-0)Category: tetrahydrofurans. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Quantitative structure-activity relations for the inhibition of guanine phosphoribosyltransferase from Escherichia coli.HPLC of Formula: 3066-84-0.

Electronic parameters calculated by HMO and Del Re methods and steric parameters calculated by the minimal steric difference (MTD) method are correlated with biol. activities for a series of 39 purinic derivatives tested as inhibitors of guanine phosphoribosyltransferase (GPRT) from E. coli. The best correlational equations thus obtained were tested on a series of 23 purinic derivatives for which inhibition constants are quoted as <3 by R. L. Miller et al. (1972). The correlational equations show that interactions between inhibitors and the active site of GPRT are controlled by both electronic and steric factors. I hope my short article helps more people learn about this compound(8-Bromoguanine)HPLC of Formula: 3066-84-0. Apart from the compound(3066-84-0), you can read my other articles to know other related compounds.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem