Recommanded Product: (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid, Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment.
2,3-Dideoxyribose in suitably protected form was prepared from glutamic acid and coupled with silylated cytosine to give a mixture of the alpha-and beta-anomers of 2′,3′-dideoxycitidine.The anomer ratio depended on the Lewis acid used in the coupling, with EtAlCl2 favoring the beta-anomer ddC, a potent anti-HIV drug.Conjugate addition of cyanide to a 4-<(silyloxy)methyl>butenolide prepared from D-ribonolactone gave a mixture of (racemic) alpha- and beta-3-cyanobutyrolactones.Both isomers were reduced to lactols and coupled with thymine to give alpha/beta-anomer pairs.The alpha-cyano lactone, the struct ure of which was established by X-ray crystallography, afforded an authentic sample of the putative (but in fact inactive) anti-HIV substance known in AIDS research as CNT.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem