Category: 20028-53-9

Computed Properties of C7H6ClNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. Author is Haddadin, Makhluf J.; Zerdan, Raghida M. Bou; Kurth, Mark J.; Fettinger, James C..

A facile, efficient, three-step protocol for the synthesis of quinolino[2,3-c]cinnoline derivatives I [R1 = H, R2 = H, R3 = H, R4 = H; R1 = H, R2 = H, R3 = H, R4 = Me; R1 = H, R2 = H, R3 = Cl, R4 = H; R1 = Br, R2 = H, R3 = Br, R4 = H; R1 = H, R2 = H, R3 = Br, R4 = H; R1 = H, R2 = OMe, R3 = OMe, R4 = H] was introduced. In addition, a new approach for the preparation of the biol. active neocryptolepine I [R3 = H] and its chloro derivative I [R3 = Cl] in good overall yields was described.

Although many compounds look similar to this compound(20028-53-9)Computed Properties of C7H6ClNO, numerous studies have shown that this compound(SMILES:NC1=CC=C(Cl)C=C1C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Godino-Ojer, M.; Martin-Aranda, R. M.; Maldonado-Hodar, F. J.; Perez-Cadenas, A. F.; Perez-Mayoral, E. researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Product Details of 20028-53-9.They published the article 《Developing strategies for the preparation of Co-carbon catalysts involved in the free solvent selective synthesis of aza-heterocycles》 about this compound( cas:20028-53-9 ) in Molecular Catalysis. Keywords: cobalt carbon nanocatalyst preparation friedlander condensation solvent free; condensation reaction aminochlorobenaldehyde beta ketoester. We’ll tell you more about this compound (cas:20028-53-9).

We report herein different series of new zero valent Cobalt nanocarbons, as doped and supported aerogels, able to efficiently catalyze the reaction of 2-amino-5-chlorobenzaldehyde and β-ketoesters, via Friedlander reaction. The reaction works under solvent-free and mild conditions affording yields over 80% in only 30 min of reaction time. The catalysts could be reused almost during two consecutive cycles without almost any activity loss. A comparative study between supported and doped-carbon aerogels, as catalysts highly efficient in the reaction, has allowed to stablish the relationship between the catalyst structure and the catalytic performance. At this regard, different parameters such as carbonization temperature and surface chem. on the aerogels under study have been also explored. As a result, although the carbon matrix is involved in the reaction, the Co(0) nanoparticles on the carbon surface are the predominant active catalytic species. Oxygen functionalities on the oxidized samples in the surroundings of Co(0) nanoparticles probably prevent the access of the reagents, notably decreasing their catalytic performance.

Although many compounds look similar to this compound(20028-53-9)Product Details of 20028-53-9, numerous studies have shown that this compound(SMILES:NC1=CC=C(Cl)C=C1C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Regiodivergent Intramolecular Nucleophilic Addition of Ketimines for the Diverse Synthesis of Azacycles, published in 2020, which mentions a compound: 20028-53-9, mainly applied to indolyloxindole indoleacetate regioselective preparation; tetrahydrospiroquinolineoxindole regioselective diastereoselective enantioselective preparation; nitroethylaniline imine oxindole ketoester regioselective cyclization; sodium catalyst regioselective cyclization nitroethylaniline imine oxindole ketoester; copper catalyst stereoselective spirocyclization nitroethylaniline imine oxindole ketoester; transition state solvent effect regioselective cyclization nitroethylaniline imine oxindole; heterocycles; indoles; organocatalysis; reaction mechanisms; synthetic methods, SDS of cas: 20028-53-9.

Imines generated in situ or prepared from isatins or aryl α-ketoesters and 2-(2-nitroethyl)anilines underwent regioselective, diastereoselective, and enantioselective cyclization reactions to yield indolyloxindoles such as I and indoleacetates or tetrahydrospiroquinolineoxindoles such as II or tetrahydroquinolinecarboxylates. Cyclocondensation of oxindoles with 2-(2-nitroethyl)anilines in MeOH in the presence of p-TsOH followed by treatment with Na2CO3 in MeOH yielded indolyloxindoles such as I, while imines prepared from 2-(2-nitroethyl)anilines and α-ketoesters underwent cyclization in the presence of Na2CO3 and KHCO3 in MeOH to yield indoleacetates. In the presence of Cu(BF4)2 and a nonracemic bisoxazoline, imines prepared from isatins and 2-(2-nitroethyl)anilines underwent regioselective, diastereoselective, and enantioselective cyclization to yield tetrahydrospiroquinolineoxindoles. Selected products were further functionalized; I was converted in three steps to a nonracemic intermediate in the preparation of (-)-psychotrimine. Computational study of the mechanism and of the effect of solvent on the reaction regiochem. indicated that hydrogen-bonding interactions facilitate the nucleophilic attack of imines at the nitrogen atom.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Catalytic Asymmetric Cascade Using Spiro-Pyrrolidine Organocatalyst: Efficient Construction of Hydrophenanthridine Derivatives. Author is Tian, Jin-Miao; Yuan, Yong-Hai; Xie, Yu-Yang; Zhang, Shu-Yu; Ma, Wen-Qiang; Zhang, Fu-Min; Wang, Shao-Hua; Zhang, Xiao-Ming; Tu, Yong-Qiang.

In the presence of a nonracemic azaspirononane and DMAP, ortho-aminoaryl-α,β-unsaturated ketones such as I underwent diastereoselective and enantioselective tandem Michael addition and aldol condensation reactions with α,β-unsaturated aldehydes such as (E)-RCH:CHCHO (R = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 2-thienyl, 2-furanyl, EtO2C, Me) to yield tetrahydrophenanthridinones such as II (R = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 2-thienyl, 2-furanyl, EtO2C, Me) with trans-ring junctions in 36-52% yields and in 88->99% ee. When ortho-aminoaryl-α,β-unsaturated ketones with two substituents ortho to the unsaturated ketone moiety were reacted with α,β-unsaturated aldehydes, tetrahydrophenanthridinones such as III (R1 = Br, Cl, Me) with cis-ring junctions were formed in 35-46% yields and in 78-99% ee. II (R = Ph) was prepared on gram scale using this method.

Compounds in my other articles are similar to this one(2-Amino-5-chlorobenzaldehyde)COA of Formula: C7H6ClNO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 2-Amino-5-chlorobenzaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Molecular Iodine-Catalysed Benzylic sp3 C-H Bond Amination for the Synthesis of 2-Arylquinazolines from 2-Aminobenzaldehydes, 2-Aminobenzophenones and 2-Aminobenzyl Alcohols. Author is Deshmukh, Dewal S.; Bhanage, Bhalchandra M..

Mol. iodine catalyzed benzylic sp3 C-H bond amination has been developed for the synthesis of quinazolines I (R = H, Ph; R1 = H, 6-Cl, 6,8-Br2; R2 = 4-chlorophenyl, pyridin-3-yl, furan-2-yl, etc.) from 2-aminobenzaldehydes such as 2-amino-5-chlorobenzaldehyde, 2-aminobenzaldehyde, 2-amino-3,5-dibromobenzaldehyde and 2-aminobenzophenones such as 2-aminobenzophenone, 2-amino-5-chlorobenzophenone with benzylamines RCH2NH2. The use of oxygen as a green oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodol. economical and greener. The lack of aqueous work up also enhances the efficiency of this protocol. A series of 2-arylquinazolines I was synthesized in good to excellent yields by using the developed protocol. The series of 2-aminobenzyl alc. could also be employed to prepare the corresponding quinazoline derivatives

Compounds in my other articles are similar to this one(2-Amino-5-chlorobenzaldehyde)Recommanded Product: 2-Amino-5-chlorobenzaldehyde, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Regiodivergent Intramolecular Nucleophilic Addition of Ketimines for the Diverse Synthesis of Azacycles, published in 2020, which mentions a compound: 20028-53-9, mainly applied to indolyloxindole indoleacetate regioselective preparation; tetrahydrospiroquinolineoxindole regioselective diastereoselective enantioselective preparation; nitroethylaniline imine oxindole ketoester regioselective cyclization; sodium catalyst regioselective cyclization nitroethylaniline imine oxindole ketoester; copper catalyst stereoselective spirocyclization nitroethylaniline imine oxindole ketoester; transition state solvent effect regioselective cyclization nitroethylaniline imine oxindole; heterocycles; indoles; organocatalysis; reaction mechanisms; synthetic methods, SDS of cas: 20028-53-9.

Imines generated in situ or prepared from isatins or aryl α-ketoesters and 2-(2-nitroethyl)anilines underwent regioselective, diastereoselective, and enantioselective cyclization reactions to yield indolyloxindoles such as I and indoleacetates or tetrahydrospiroquinolineoxindoles such as II or tetrahydroquinolinecarboxylates. Cyclocondensation of oxindoles with 2-(2-nitroethyl)anilines in MeOH in the presence of p-TsOH followed by treatment with Na2CO3 in MeOH yielded indolyloxindoles such as I, while imines prepared from 2-(2-nitroethyl)anilines and α-ketoesters underwent cyclization in the presence of Na2CO3 and KHCO3 in MeOH to yield indoleacetates. In the presence of Cu(BF4)2 and a nonracemic bisoxazoline, imines prepared from isatins and 2-(2-nitroethyl)anilines underwent regioselective, diastereoselective, and enantioselective cyclization to yield tetrahydrospiroquinolineoxindoles. Selected products were further functionalized; I was converted in three steps to a nonracemic intermediate in the preparation of (-)-psychotrimine. Computational study of the mechanism and of the effect of solvent on the reaction regiochem. indicated that hydrogen-bonding interactions facilitate the nucleophilic attack of imines at the nitrogen atom.

Compounds in my other articles are similar to this one(2-Amino-5-chlorobenzaldehyde)SDS of cas: 20028-53-9, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Catalytic Asymmetric Cascade Using Spiro-Pyrrolidine Organocatalyst: Efficient Construction of Hydrophenanthridine Derivatives. Author is Tian, Jin-Miao; Yuan, Yong-Hai; Xie, Yu-Yang; Zhang, Shu-Yu; Ma, Wen-Qiang; Zhang, Fu-Min; Wang, Shao-Hua; Zhang, Xiao-Ming; Tu, Yong-Qiang.

In the presence of a nonracemic azaspirononane and DMAP, ortho-aminoaryl-α,β-unsaturated ketones such as I underwent diastereoselective and enantioselective tandem Michael addition and aldol condensation reactions with α,β-unsaturated aldehydes such as (E)-RCH:CHCHO (R = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 2-thienyl, 2-furanyl, EtO2C, Me) to yield tetrahydrophenanthridinones such as II (R = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-O2NC6H4, 2-thienyl, 2-furanyl, EtO2C, Me) with trans-ring junctions in 36-52% yields and in 88->99% ee. When ortho-aminoaryl-α,β-unsaturated ketones with two substituents ortho to the unsaturated ketone moiety were reacted with α,β-unsaturated aldehydes, tetrahydrophenanthridinones such as III (R1 = Br, Cl, Me) with cis-ring junctions were formed in 35-46% yields and in 78-99% ee. II (R = Ph) was prepared on gram scale using this method.

Compounds in my other articles are similar to this one(2-Amino-5-chlorobenzaldehyde)COA of Formula: C7H6ClNO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 2-Amino-5-chlorobenzaldehyde. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Molecular Iodine-Catalysed Benzylic sp3 C-H Bond Amination for the Synthesis of 2-Arylquinazolines from 2-Aminobenzaldehydes, 2-Aminobenzophenones and 2-Aminobenzyl Alcohols. Author is Deshmukh, Dewal S.; Bhanage, Bhalchandra M..

Mol. iodine catalyzed benzylic sp3 C-H bond amination has been developed for the synthesis of quinazolines I (R = H, Ph; R1 = H, 6-Cl, 6,8-Br2; R2 = 4-chlorophenyl, pyridin-3-yl, furan-2-yl, etc.) from 2-aminobenzaldehydes such as 2-amino-5-chlorobenzaldehyde, 2-aminobenzaldehyde, 2-amino-3,5-dibromobenzaldehyde and 2-aminobenzophenones such as 2-aminobenzophenone, 2-amino-5-chlorobenzophenone with benzylamines RCH2NH2. The use of oxygen as a green oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodol. economical and greener. The lack of aqueous work up also enhances the efficiency of this protocol. A series of 2-arylquinazolines I was synthesized in good to excellent yields by using the developed protocol. The series of 2-aminobenzyl alc. could also be employed to prepare the corresponding quinazoline derivatives

Compounds in my other articles are similar to this one(2-Amino-5-chlorobenzaldehyde)Recommanded Product: 2-Amino-5-chlorobenzaldehyde, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ) is researched.Synthetic Route of C7H6ClNO.Liu, Hu; Tian, Ye; Lee, Kyungae; Krishnan, Pranav; Wang, May Kwang-Mei; Whelan, Sean; Mevers, Emily; Soloveva, Veronica; Dedic, Benjamin; Liu, Xinyong; Cunningham, James M. published the article 《Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies》 about this compound( cas:20028-53-9 ) in Journal of Medicinal Chemistry. Keywords: adamantane dipeptide piperazine preparation antiviral Ebola virus NPC1 inhibitor. Let’s learn more about this compound (cas:20028-53-9).

Previous studies identified an adamantane dipeptide piperazine 3.47 that inhibits Ebola virus (EBOV) infection by targeting the essential receptor Niemann-Pick C1 (NPC1). The physicochem. properties of 3.47 limit its potential for testing in vivo. Optimization by improving potency, reducing hydrophobicity, and replacing labile moieties identified 3.47 derivatives with improved in vitro ADME properties that are also highly active against EBOV infection, including when tested in the presence of 50% normal human serum (NHS). In addition, 3A4 was identified as the major cytochrome P 450 isoform that metabolizes these compounds, and accordingly, mouse microsome stability was significantly improved when tested in the presence of the CYP3A4 inhibitor ritonavir that is approved for clin. use as a booster of anti-HIV drugs. Oral administration of the EBOV inhibitors with ritonavir resulted in a pharmacokinetic profile that supports a b.i.d. dosing regimen for efficacy studies in mice.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Category: tetrahydrofurans. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Iodine-Catalyzed Annulations of 2-Amino Carbonyls for Diverse 1-Azaxanthones, Quinolines, and Naphthyridines. Author is Cai, Hongyun; Datta Khanal, Hari; Rok Lee, Yong.

An efficient and facile iodine-catalyzed reaction of 2-amino carbonyls with β-enamino esters or β-enaminones afforded 1-azaxanthones, quinolines and naphthyridines in good to excellent yields. This novel catalytic [4+2] annulation reaction proceeded through a cascade I2-activation, Michael addition, intramol. aldol reaction and aromatization.

When you point to this article, it is believed that you are also very interested in this compound(20028-53-9)Category: tetrahydrofurans and due to space limitations, I can only present the most important information.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem