Properties and Exciting Facts About 2,2-Dimethylsuccinicanhydride

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The invention relates to novel betulinic acid derivatives and related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases. These compounds are esterified in position 3 and are substituted in position 17 of the betulinic acid structure, via a linking group W, by a saturated 5-7 membered nitrogen-heterocycle.

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Tetrahydrofuran – Wikipedia,
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Lipase Amano P irreversibly catalyzed a ring-opening of alpha-substituted cyclic acid anhydrides 1 preferentially at the less hindered carbonyl group to give monoesters with high regioselectivity.

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Tetrahydrofuran – Wikipedia,
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A nickel-catalyzed alkylation of succinic and glutaric anhydrides with alkyl- and arylzinc reagents has been developed. A dramatic olefin effect has been investigated resulting in the identification of several styrene-based promoters which show pronounced enhancements in reaction rate. The substrate scope with respect to electrophilic and nucleophilic coupling partners has been examined and found to be remarkably broad, allowing for rapid introduction of molecular complexity through the use of functionalized coupling partners. Regioselective alkylation of an unsymmetrical succinic anhydride and a profound effect of pendent coordinating olefins on reaction rate suggest a mechanism involving discrete oxidative addition of the nickel complex into the cyclic anhydride followed by a transmetalation event.

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Tetrahydrofuran – Wikipedia,
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Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

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Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, aza-substituted triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula (I). These compounds are useful for the treatment of HIV and AIDS.

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Screening of the Maybridge compound collection identified 4-arylphthalazinones as micromolar inhibitors of PARP-1 catalytic activity. Subsequent optimisation of both inhibitory activity and metabolic stability led to a novel series of meta-substituted 4-benzyl-2H-phthalazin-1-ones with low nanomolar, cellular activity as PARP-1 inhibitors and promising metabolic stability in vitro.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C6H8O3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 17347-61-4, name is 2,2-Dimethylsuccinicanhydride. In an article,Which mentioned a new discovery about 17347-61-4

The present invention relates to ethynyl derivatives of formula (I) as allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5). The variables in formula (I) are defined in the specification.

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Archives for Chemistry Experiments of 2,2-Dimethylsuccinicanhydride

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Abstract: We present the design and synthesis of Br°nsted-basic ionic liquids and investigate their application in the microwave-assisted esterification of betulinic acid, aiming towards a benign and pyridine-free manufacturing process of the anti-HIV drug, bevirimat. Graphical abstract: [Figure not available: see fulltext.]

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On the basis of the electron-impact mass spectra of a series of 1-diazo-4-methoxycarbonyl-2-butanones, the data from high-resolution mass spectrometry, and the spectrum of the deuterated analog it was shown that the +. ions formed at the first stage in the fragmentation of the molecular ions of these compounds are partly stabilized with the formation of pseudomolecular ions of oxolanones.The molecular ions of the diazo ketones themselves can dissociate in various directions.The many-path dissociation makes it possible to suppose that the yield of oxolanones formed during cyclization in solution under the influence of acidic agents is small.

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Compounds having the formula I: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem