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The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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An object of the present invention is to provide a process for producing a 3-cyanotetrahydrofuran derivative in a high yield from inexpensive industrial materials. According to the present invention, a 3-aminomethyltetrahydrofuran derivative is produced by preparing a 3-cyanotetrahydrofuran derivative in a high yield from an inexpensive and industrially easily available malic acid derivative, and reducing the cyano group of the 3-cyanotetrahydrofuran derivative.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Disclosed is a method for highly efficiently producing a 3-aminomethyltetrahydrofuran derivative from a low-cost industrial raw material. Specifically, a 3-cyanotetrahydrofuran derivative is produced at high yield from a low-cost, industrially easily-available malic acid derivative, and then a 3-aminomethyltetrahydrofuran derivative is produced by reducing the cyano group of the 3-cyanotetrahydrofuran derivative.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 165253-31-6

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A tetrahydrofuran – 3 – methylamine synthetic method (by machine translation)

The invention discloses a tetrahydrofuran – 3 – methylamine synthetic method, solved in the prior art tetrahydrofuran – 3 – methylamine synthesis with a route process is complicated, and the cost is high, the problem of harsh reaction conditions. The present invention includes: (1) in the organic solvent in the I, acrylonitrile and ethylene oxide in the presence of a catalyst A produced by the reaction of 3 – cyano – tetrahydrofuran; (2) 3 – cyano – tetrahydrofuran in the organic solvent after the purification catalyst under the condition B II and reduction to obtain tetrahydrofuran – 3 – methylamine. The invention greatly shortens the technological process and production cycle, and is simple, environmental protection, low cost, simple operation, high yield, has significant social and economic benefits and commercial application value. (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase

Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a catalytically important zinc ion in the active site. A series of de novo designed compounds containing a zinc binding group was synthesized and evaluated for antibacterial activity and interaction with IspF from Burkholderia pseudomallei, the causative agent of Whitmore’s disease. The series demonstrated antibacterial activity as well as protein stabilization in fluorescence-based thermal shift assays. Finally, the binding of one compound to Burkholderia pseudomallei IspF was evaluated through group epitope mapping by saturation transfer difference NMR.

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Tetrahydrofuran – Wikipedia,
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A 3 – methyl tetrahydrofuran production process of ammonia (by machine translation)

The invention discloses a 3 – aminomethyl tetrahydrofuran production process, which belongs to the field of agricultural chemical intermediate synthesis process. The craft in order to 2 – butene – 1, 4 – diol as the starting material, dehydration cyclization, hydroformylation and three-step reaction synthesizes the reductive amination of 3 – amino methyl tetrahydrofuran. The present invention production process of mild reaction conditions, low cost, three wastes, is suitable for industrial production. (by machine translation)

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Poly(beta-aminosulfonamides) as gene delivery vectors: Synthesis and in vitro screening

A series of poly(beta-aminosulfonamides) was synthesized and demonstrated to be efficient in vitro transfection reagents. The Royal Society of Chemistry.

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Tetrahydrofuran – Wikipedia,
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AMIDE COMPOUND

A method is provided for producing an amide compound having an excellent control effect on arthropod pests. The method includes an arthropod pest control agent that contains the compound, and a step of applying an effective amount of the compound to control the arthropod pest or an arthropod pest-infested area.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

A non-methionine FT inhibitor lead structure (1) was designed through computer modeling of the peptidomimetic FT inhibitor ABT839. Optimization of this lead resulted in compounds 2e and 2g, with FT IC50 values of 1.3 and 1.8 nM, GGT IC50 of 1400 nM, and EC50 (Ras processing) values of 13 and 11 nM, respectively.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem