Category: 160709-02-4

HPLC of Formula: 160709-02-4On March 15, 2015, Jin, Feng-min; Zhang, Jing published an article in Zhongguo Xinyao Zazhi. The article was 《Synthesis of posaconazole》. The article mentions the following:

Objective: To improve the synthesis process of posaconazole. Methods: Posaconazole was synthesized from 1-(1-bromomethyl-vinyl)-2,4-difluoro-benzene by several reactions such as esterification, reduction and enzymic acetylation. Results: The overall yield was 27.7%. Conclusion: This synthetic process had the advantages of simpler purifying operation, lower cost and mild condition, so it could be used in industrial manufacturing In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4HPLC of Formula: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 160709-02-4On March 13, 1995, Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Lovey, Raymond G.; Pike, Russell E.; Wang, Haiyan; Ganguly, Ashit K.; Morgan, Brian; Zaks, Alesey; Puar, Mohinder S. published an article in Tetrahedron Letters. The article was 《Highly stereoselective access to novel 2,2,4-trisubstituted tetrahydrofurans by halocyclization: practical chemoenzymic synthesis of SCH 51048, a broad-spectrum orally active antifungal agent》. The article mentions the following:

A convenient synthesis of (-)-(2R)-cis-tosylate I is reported via stereoselective 5-exo-iodocyclization of the optically active 2,2-disubstituted olefin II. Enzymic desymmetrization of the homoallylic diol III with Novo SP435 allowed optimal pro(S) selectivity to provide the desired (-)-monoacetate II. Under the irreversible reaction conditions, the presence of a bulky aryl substituent on the 2,2-disubstituted olefin seems to determine stereochem. outcome of these halocyclizations. The experimental part of the paper was very detailed, including the reaction process of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Vlyyoor M. published their research in Tetrahedron Letters on August 15 ,1994. The article was titled 《PPL-catalyzed enzymic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: improvements toward synthesis of the eutomers of SCH 45012》.Recommanded Product: 160709-02-4 The article contains the following contents:

Porcine pancreatic lipase catalysis has been used to establish both stereocenters of (tetrahydrofuranylmethyl)tosylate I. In addition to the enzymic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of triol (R)-II [R1 = CH(CH2OH)2], successful enzymic resolution of the racemic diol II (R1 = OH) provided an alternate route to the important precursor diol (R)-II (R1 = OH). In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Wang, Haiyan; Liu, Yi-Tsung; Pike, Russell E.; Ganguly, Ashit K. published their research in Tetrahedron Letters on August 5 ,1996. The article was titled 《Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: key intermediates towards synthesis of highly active azole antifungals Sch 51048 and Sch 56592》.Application of 160709-02-4 The article contains the following contents:

Two complimentary approaches to the key (-)-(2R)-cis-tosylate I and its (+)-(2S)-enantiomer via generation of chiral imide enolates having a 2,2-disubstituted olefin functionality in the β-position, are described. In a “”protecting group free”” sequence, reaction of the titanium enolate generated from (4R)-benzyl-2-oxazolidinone derived imide II with s-trioxane provided a convenient oxazolidinone intermediate III which could be directly subjected to 2,4-diastereoselective iodocycln. In the experimental materials used by the author, we found ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Application of 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application of 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Chinese Journal of Structural Chemistry included an article by Han, Hao; Zhang, Zhi-Fang; Zhang, Jun-Fei; Zhang, Bin. Product Details of 160709-02-4. The article was titled 《Synthesis, crystal structure and anti-breast cancer activity of ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate》. The information in the text is summarized as follows:

The new heterocycle compound ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1), designed using ((3R,5S)-5-(2,4-difluorophenyl)-5-iodotetrahydrofuran-3-yl)methyl isobutyrate (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, and single-crystal X-ray crystallog. In addition, the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against three human breast cancer cell lines BT474, MCF7 and MB. The experimental part of the paper was very detailed, including the reaction process of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Product Details of 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem